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Device and method for encapsulated gene therapy

  • US 6,027,721 A
  • Filed: 05/20/1996
  • Issued: 02/22/2000
  • Est. Priority Date: 05/20/1996
  • Status: Expired due to Term
First Claim
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1. A biocompatible capsule comprising:

  • a core comprising living packaging cells that secrete a viral vector for infection of a target cell, wherein the viral vector is a retroviral vector, the vector comprising a heterologous gene encoding a biologically active molecule operably linked to a promoter that regulates expression of the biologically active molecule in the target cell, the heterologous gene being no more than 8 kb in length; and

    an external jacket surrounding said core, said jacket comprising a permeable biocompatible material, said material having a porosity selected to permit passage of retroviral vectors of 100 nm diameter thereacross, permitting release of said viral vector from said capsule.

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