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Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals

  • US 6,027,898 A
  • Filed: 08/18/1998
  • Issued: 02/22/2000
  • Est. Priority Date: 08/18/1997
  • Status: Expired due to Term
First Claim
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1. A method for analyzing a sample of double stranded DNA to determine the presence of a mutation site therein comprising:

  • a) contacting said sample with a mutation site binding reagent which binds within the vicinity of said mutation site, andb) chromatographically separating and detecting the product of step (a) while the mutation site binding reagent remains bound to the mutation site.

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