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Pyrimidine derivatives and oligonucleotides containing same

  • US 6,028,183 A
  • Filed: 11/07/1997
  • Issued: 02/22/2000
  • Est. Priority Date: 11/07/1997
  • Status: Expired
First Claim
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1. A compound having the structure (1):

  • ##STR38## and tautomers, solvates and salts thereof, wherein R1 is an oligonucleotide, a protecting group, a linker or --H;

    R2 is A(Z)X1, wherein A is a spacer and Z independently is a label bonding group optionally bonded to a detectable label, but R2 is not amine, protected amine, nitro or cyano;

    R27 is independently --CH═

    , --N═

    , --C(C1 -C8 alkyl)═

    or --C(halogen)═

    , but no adjacent R27 are both --N═

    , or two adjacent R27 are taken together to form a ring having the structure, ##STR39## where Ra is independently --CH═

    , --N═

    , --C(C1-8 alkyl)═

    or --C(halogen)═

    , but no adjacent Ra are both --N═

    ;

    R34 is --O--, --S-- or --N(CH3)--; and

    X1 is 1, 2 or 3.

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