Circuit and method for automatically turning off an iontophoresis system

• US 6,029,083 A
• Filed: 04/04/1997
• Issued: 02/22/2000
• Est. Priority Date: 04/04/1997
• Status: Expired due to Fees

• Current Assignee: Vyteris, Inc.
• Original Assignee: Becton, Dickinson & Co
• Inventors: Garde, Kenneth E., Flower, Ronald J.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/835,085
• Time in Patent Office: 1,054 Days
• Field of Search: 604/20-21, 607/149-153, 607/59
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0432 Anode and cathode
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

A fail-safe iontophoretic drug delivery apparatus and a corresponding method is provided. The apparatus includes a current generating circuit for sending a current through a patch, error detection circuitry, and a control circuit. The control circuit controls the current generating circuit. When errors are detected in the apparatus, the control circuit stops the current and disables itself.

Claims

1. A controller for an iontophoretic drug delivery apparatus, comprising:

a current control circuit;

error detection circuitry for detecting at least one error condition within the apparatus; and

a control circuit including a microprocessor capable of controlling said current control circuit, said control circuit being capable of disabling itself from reading instruction when said error detection circuitry detects the at least one error condition, said controller further comprising power-on reset circuitry to ensure that said control circuit is not disabled when power is initially applied.

2. The apparatus according to claim 1, further comprising a battery draining circuit that is activated when the control circuit is disabled.

3. The apparatus according to claim 1, wherein the error detection circuitry detects at least one of the conditions of low battery voltage, reference voltage failure, clock failure, current generating circuit overvoltage, current generating circuit overcurrent, excess time-current product, expired patch installed, and incorrect patch installed.

4. The apparatus according to claim 1, further comprising an iontophoretic patch, said patch being electrically connectable to said current generating circuit, said patch for delivering drugs to the patient when said current generating circuit is in an operational state.

5. A controller for an iontophoretic drug delivery apparatus, comprising:

a current control circuit;

means for providing a clock signal;

error detection circuitry for detecting at least one error condition within the apparatus; and

a control circuit capable of controlling said current control circuit, said control circuit having a clock input, said control circuit being capable of operating only when a clock signal is applied to the clock input, said control circuit being further capable of stopping the clock signal applied to the clock input when said error detection circuitry detects the at least one error condition.

6. The apparatus according to claim 5, wherein said current generating circuit is shut off when the clock signal is stopped.

7. The apparatus according to claim 6, further comprising power-on reset circuitry to ensure that the clock signal is on when power is initially applied.

8. The apparatus according to claim 6, wherein the control circuit comprises a microprocessor.

9. The apparatus according to claim 6, further comprising a battery draining circuit that is activated when the clock signal is stopped.

10. The apparatus according to claim 9, wherein the battery draining circuit comprises at least one of an SCR, a bipolar transistor, and an FET.

11. The apparatus according to claim 6, wherein the error detection circuitry detects at least one of the conditions of low battery voltage, reference voltage failure, clock failure, current generating circuit overvoltage, current generating circuit overcurrent, excess time-current product, expired patch installed, and incorrect patch installed.

12. The apparatus according to claim 6, further comprising an iontophoretic patch, said patch being electrically connectable to said current generating circuit, said patch for delivering drugs to the patient when said current generating circuit is in an operational state.

13. A controller for an iontophoretic drug delivery apparatus, comprising:

a current control circuit;

means for providing a clock signal;

a data storage device having an output, wherein the output is in a first state when certain data is stored in said data storage device, and is not in the first state when the certain data is not stored in said data storage device;

a control circuit capable of controlling said current generating circuit and capable of causing the certain data to be stored into said data storage device, said control circuit having a clock input, said control circuit being capable of operating only when a clock signal is applied to the clock input;

a logic circuit having an output connected to the clock input of the control circuit, a control input connected to the output of the data storage device, and a clock input adapted to receive a first clock signal, wherein a second clock signal is produced at the logic circuit output only when the data storage device output is not in the first state;

error detection circuitry for detecting at least one error condition within the system; and

power-on reset circuitry to ensure that the certain data is not stored in said data storage device when power is initially applied, wherein said control circuit causes the certain data to be stored in said data storage device when said error detection circuitry detects the at least one error condition, and wherein said current generating circuit is shut off when the certain data is stored in said data storage device.

14. The apparatus according to claim 13, wherein said control circuit comprises a microprocessor.

15. The apparatus according to claim 13, further comprising a battery draining circuit that is activated when the certain data is stored in said data storage device.

16. The apparatus according to claim 15, wherein the battery draining circuit comprises at least one of an SCR, a bipolar transistor, and an FET.

17. The apparatus according to claim 13, wherein the error detection circuitry detects at least one of the conditions of low battery voltage, reference voltage failure, clock failure, current generating circuit overvoltage, current generating circuit overcurrent, excess time-current product, expired patch installed, and incorrect patch installed.

18. The apparatus according to claim 13, wherein the data storage device comprises one of a group consisting of a register, latch, RAM, PROM, EPROM, EEPROM, and fuse programmable device.

19. The apparatus according to claim 13, further comprising an iontophoretic patch, said patch being electrically connectable to said current generating circuit, said patch for delivering drugs to the patient when said current generating circuit is in an operational state.

20. A method of shutting down an iontophoretic drug delivery system, comprising the steps of:

providing a clock signal;

controlling an iontophoretic current using a control circuit having a clock input, the control circuit being capable of operating only when a clock signal is applied to the clock input;

detecting at least one error condition within the system; and

generating a signal by the control circuit that stops the clock signal from being delivered to the clock output after the at least one error condition is detected in said detecting step.

21. The method according to claim 20, further comprising the step of stopping the iontophoretic current when the clock signal is stopped.

22. The method according to claim 20, further comprising the step of starting the clock signal when power is initially applied.

23. A method of shutting down an iontophoretic drug delivery system, comprising the steps of:

controlling an iontophoretic current using a control circuit including a microprocessor capable of being disabled;

detecting at least one error condition within the system; and

disabling the ability of the control circuit microprocessor from reading instructions after the at least one error condition is detected in said detecting step.

24. The method according to claim 23, further comprising the step of stopping the iontophoretic current when the control circuit is disabled.