Substance delivery apparatus

• US 6,029,660 A
• Filed: 12/12/1997
• Issued: 02/29/2000
• Est. Priority Date: 12/12/1996
• Status: Expired due to Term

• Current Assignee: Resmed Limited (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Calluaud, Michel, Yerbury, Victor
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): WEISS JR, JOSEPH
• Application Number:
  US08/989,150
• Time in Patent Office: 809 Days
• Field of Search: 128/200.21, 128/203.12, 128/203.16, 128/203.22, 128/203.25, 128/204.18, 128/204.22, 128/204.23
• US Class Current: 128/203.12
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 16/14 by mixing different fluids, one of them being in a liquid phase
• CPC Class Codes: A61M 16/147 the respiratory gas not passing through the liquid container
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit

Abstract

A substance delivery apparatus (10) for use with a system (12) for supplying breathable gas to a human or animal. The apparatus includes a mechanism (22) to measure the pressure of the supplied breathable gas (22) to detect inhalation by the human or animal; and elements (54, 56, 58, 60) to deliver the substance (52) to the human or animal during inhalation at a pressure higher than the supplied pressure of the breathable gas. A method of delivering a substance (52) is also disclosed.

Claims

1. A substance delivery apparatus for use with a system for supplying breathable gas to a human or animal, said system including a pressurized gas flow generator in fluid communication with a mask worn by the human or animal via a flexible conduit, the apparatus including:

an airflow sensor adapted to measure the volumetric flow rate of the breathable gas passing through the conduit and generate a first signal indicative of the breathable gas flow rate;

a first amplifier to amplify the first input signal into a second input signal also indicative of the breathable gas flow rate;

a differentiating filter to derive the first input signal into a third input signal indicative of acceleration or deceleration of the breathable gas and inhalation or exhalation respectively;

a linear drive means;

a positive displacement diaphragm pump displaced by the linear drive means to deliver the substance to the human or animal during inhalation at a pressure higher than the supplied pressure of the breathable gas;

a pressure transducer connected to the conduit, the transducer being adapted to generate a fourth input signal indicative of the pressure of the supplied breathable gas;

a second amplifier to amplify the fourth input signal into a fifth input signal also indicative of the breathable gas pressure;

a first control system having input means adapted to allow the input of a predetermined sixth input signal indicative of the volume of the substance to be delivered and a predetermined seventh input signal indicative of the amount by which the pressure of the delivered substance is to exceed the pressure of the supplied breathable gas,

wherein said first control system is adapted to receive the second, third, fifth, sixth and seventh input signals and calculate and generate a first output signal indicative of the amount of displacement of the linear drive means and a second output signal indicative of the direction of the displacement required to produce a negative or positive pumping pressure.

2. An apparatus as claimed in claim 1, wherein the substance is a medicinal substance.

3. An apparatus as claimed in claim 1, wherein the substance is in the form of a gas, mist, aerated suspension, jet, spray, gas mixture.

4. An apparatus as claimed in claim 1, wherein the substance is delivered to the respiratory system of the human or animal.

5. An apparatus as claimed in claim 4, wherein the substance is delivered to the nasal airways of the human or animal.

6. An apparatus as claimed in claim 1, further including means to measure the volume of the substance to be delivered to the human or animal.

7. An apparatus as claimed in claim 1, wherein the diaphragm pump is in fluid communication with a substance reservoir via a one-way valve adapted to allow the substance to only pass from the reservoir to the diaphragm pump.

8. An apparatus as claimed in claim 1, wherein the diaphragm pump is in fluid communication with the gas supply conduit via a one-way valve adapted to allow the substance to only pass from the diaphragm pump to the conduit.

9. An apparatus as claimed in claim 1, wherein the linear drive means is an electromagnet.

10. An apparatus as claimed in claim 1, wherein a negative pumping pressure draws the substance from the substance reservoir into the pump and a positive pumping pressure expels the substance from the pump to the conduit and so to the human or animal.

11. An apparatus as claimed in claim 10, wherein the first and second output signals are sent to a second control system adapted to convert them into third and fourth output signals indicative of drive means displacement and direction respectively, the third and fourth output signals being compatible with the linear drive means.

12. An apparatus as claimed in claim 11, wherein the input and output signals are analog or digital.

13. A method of delivering a substance to a human or animal being supplied with breathable gas, the method including the steps of:

measuring the volumetric flow rate of the supplied breathable gas with an air flow sensor adapted to generate a first input signal indicative of the volumetric flow rate of the supplied breathable gas;

amplifying the first input signal into a second input signal also indicative of the volumetric flow rate of the supplied breathable gas;

differentiating the first input signal into a third input signal indicative of breathable gas acceleration or deceleration to detect inhalation or exhalation respectively;

measuring the pressure of the supplied breathable gas with a pressure transducer adapted to generate a fourth input signal indicative of the pressure of the supplied breathable gas;

amplifying the fourth input signal into a fifth input signal also indicative of the pressure of the supplied breathable gas;

inputting the second, third, fourth, fifth input signals and a predetermined sixth input signal indicative of the volume of the substance to be delivered and a predetermined seventh input signal indicative of the amount by which the pressure of the delivered substance should exceed the pressure of the breathable gas into a first control system, the first control system adapted to generating a first output signal indicative of the amount of displacement of a linear drive means and a second output signal indicative of the direction of the displacement required to produce negative or positive pumping pressure; and

delivering the substance to the human or animal during inhalation at a pressure higher than the supplied pressure of the breathable gas using a positive displacement diaphragm pump driven by the linear drive means.

14. A method as claimed in claim 13, wherein the substance is a medicinal substance.

15. A method as claimed in claim 14, wherein the substance is in the form of a gas, mist, aerated suspension, jet, spray, gas mixture.

16. A method as claimed in claim 13, wherein the substance is delivered to the respiratory system of the human or animal.

17. A method as claimed in claim 16, wherein the substance is delivered to the nasal airways of the human or animal.

18. A method as claimed in claim 13, wherein the supplied breathable gas is pressurised above atmospheric pressure.

19. A method as claimed in any one of claim 13, wherein the diaphragm pump is in fluid communication with a substance reservoir via a one-way valve adapted to allow the substance to only pass from the reservoir to the diaphragm pump.

20. A method as claimed in claim 13, wherein the diaphragm pump is in fluid communication with the gas supply conduit via a one-way valve adapted to allow the substance to only pass from the diaphragm pump to the conduit.

21. A method as claimed in claim 13, wherein the linear drive means is an electromagnet.

22. A method as claimed in claim 13, wherein a negative pumping pressure draws the substance from the substance reservoir into the pump and a positive pumping pressure expels the substance from the pump to the conduit and so to the human or animal.

23. A method as claimed in claim 22, further including the steps of inputting the first and second output signals into a second control system and the second control system adapted converting them into third and fourth output signals indicative of drive means displacement length and direction respectively, the third and fourth output signals being compatible with the linear or rotary drive means.