Microcatheter and method for site specific therapy

• US 6,030,358 A
• Filed: 08/08/1997
• Issued: 02/29/2000
• Est. Priority Date: 08/08/1997
• Status: Expired due to Term

• Current Assignee: Twin Star Medical, Inc.
• Original Assignee: Twin Star Medical, Inc.
• Inventors: Odland, Rick Matthew
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): Gring, Kent
• Application Number:
  US08/908,555
• Time in Patent Office: 935 Days
• Field of Search: 604/93, 604/264, 604/280, 604/27, 604/28, 604/48, 604/49, 604/53, 604/19, 604/43, 128/632, 128/768
• US Class Current: 604/27
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum

Abstract

An apparatus having a pump reservoir and one or more microcatheters, for use in delivering and/or recovering fluid to and/or from a tissue site or for performing tissue engineering outside of the body. The apparatus can be used in a method to perform site specific microtherapy, including for the treatment of avascular necrosis, compartment syndrome, cerebral edema, and to improve skin flap survival in the course of reconstructive surgery.

Claims

1. An apparatus for performing site specific microtherapy comprising a pump reservoir and one or more microcatheters dimensioned to be positioned within a tissue site for selectively removing fluids by microdialysis from the tissue site, the microcatheter(s) being adapted for fluid communication with the pump reservoir to effect the recovery of fluid, the apparatus further comprising a delivery sheath adapted to be positioned into the tissue site, the microcatheter assembly adapted to be positioned within the delivery sheath, the delivery sheath having walls sufficiently permeable to permit a desired flow of fluids between the tissue and the microcatheter assembly in the course of microdialysis.

2. A kit comprising an apparatus according to claim 1 wherein the microcatheter assembly comprises a plurality of microcatheters adapted to be positioned within the delivery sheath.

3. A kit according to claim 2 wherein the microcatheter assembly is adapted to perform microdialysis based on size exclusion in order to remove tissue fluids and solutes based on solute size.

4. A kit according to claim 3 wherein the microcatheter assembly comprises a plurality of microcatheters, each in the form of a capillary tube having a lumen and semipermeable wall.

5. A kit according to claim 2 wherein the apparatus provides a plurality of fluid passageways.

6. A kit according to claim 5 wherein the passageways comprise a passageway adapted to deliver a solution to the tissue and a second passageway adapted to recover fluid from the tissue.

7. A kit according to claim 2 wherein the apparatus is adapted to permit physiologic parameters to be simultaneously monitored.

8. A kit according to claim 2 wherein the apparatus is adapted for use in treating cerebral edema.

9. An apparatus according to claim 1 wherein the microcatheter assembly is adapted to perform microdialysis based on size exclusion in order to remove tissue fluids and solutes based on solute size.

10. An apparatus according to claim 9 wherein the microcatheter assembly comprises a plurality of microcatheters, each in the form of a capillary tube having a lumen and semipermeable wall.

11. An apparatus according to claim 1 wherein the apparatus provides a plurality of fluid passageways.

12. An apparatus according to claim 11 wherein the passageways comprise a passageway adapted to deliver a solution to the tissue and a second passageway adapted to recover fluid from the tissue.

13. An apparatus according to claim 1 wherein the apparatus is adapted to permit physiologic parameters to be simultaneously monitored.

14. An apparatus according to claim 1 wherein the apparatus is adapted for use in treating cerebral edema.

15. A method of performing site specific microdialysis, the method comprising the steps of:

a) providing an apparatus comprising one or more microcatheters dimensioned to be positioned within a tissue site for selectively removing fluids by microdialysis from the tissue site, the microcatheter(s) being adapted for fluid communication with a reservoir component for the recovery of fluid, the apparatus further comprising a delivery sheath adapted to be positioned into the tissue site, the microcatheter assembly adapted to be positioned within the delivery sheath, the delivery sheath having walls sufficiently permeable to permit a desired flow of fluids between the tissue and the microcatheter assembly in the course of microdialysis

b) positioning the delivery sheath and microcatheter assembly of the apparatus within a tissue site, and

c) employing the apparatus to selectively remove fluid by microdialysis from the tissue site.

16. A method according to claim 15 wherein the microcatheter assembly is adapted to perform microdialysis based on size exclusion in order to remove tissue fluids and solutes based on solute size.

17. A method according to claim 16 wherein the microcatheter assembly comprises a plurality of microcatheters, each in the form of a capillary tube having a lumen and semipermeable wall.

18. A method according to claim 15 wherein the apparatus provides a plurality of fluid passageways.

19. A method according to claim 18 wherein the passageways comprise a passageway adapted to deliver a solution to the tissue and a second passageway adapted to recover fluid from the tissue.

20. A method according to claim 15 wherein the apparatus is adapted to permit physiologic parameters to be simultaneously monitored.

21. A method according to claim 15 wherein the apparatus is adapted for use in treating cerebral edema.