Non-leaching antimicrobial films

• US 6,030,632 A
• Filed: 09/11/1998
• Issued: 02/29/2000
• Est. Priority Date: 12/20/1993
• Status: Expired due to Term

• Current Assignee: Surfacine Development Company LLC
• Original Assignee: Biopolymerix and Surfacine Development Company
• Inventors: Yurkovetskiy, Alexander, Sawan, Samuel P., Subramanyam, Sundar
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US09/151,866
• Time in Patent Office: 536 Days
• Field of Search: 424/406, 424/405, 424/408-409, 424/411, 424/412, 424/421, 424/78.09, 424/78.12, 424/78.27, 424/78.34, 424/78.35, 424/617, 424/618, 424/630, 424/639 , 424/641, 424/646, 424/649-685, 514/492-505, 514/634, 514/635, 523/122
• US Class Current: 424/405
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/24 containing ingredients to enhance the sticking of the active ingredients
• CPC Class Codes: A01N 25/26 in coated particulate form
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61J 1/145 using air filters
• CPC Class Codes: A61J 1/1456 using liquid filters
• CPC Class Codes: A61J 1/1468 Containers characterised by specific material properties
• CPC Class Codes: A61L 2/16 using chemical substances
• CPC Class Codes: B01D 2239/0442 Antimicrobial, antibacterial, antifungal additives
• CPC Class Codes: B01D 2239/0471 Surface coating material
• CPC Class Codes: B01D 2239/0478 on a layer of the filter
• CPC Class Codes: B01D 2323/02 Hydrophilization
• CPC Class Codes: B01D 2323/04 Hydrophobization
• CPC Class Codes: B01D 2325/38 Hydrophobic membranes
• CPC Class Codes: B01D 2325/48 Antimicrobial properties
• CPC Class Codes: B01D 39/00 Filtering material for liquid or gaseous fluids
• CPC Class Codes: B01D 39/16 of organic material, e.g. synthetic fibres
• CPC Class Codes: B01D 39/1623 : of synthetic origin
• CPC Class Codes: B01D 39/1692 : Other shaped material, e.g. perforated or porous sheets
• CPC Class Codes: B01D 67/0069 : by deposition from the liquid phase, e.g. electrochemical deposition B01D67/0046 takes precedence
• CPC Class Codes: B01D 67/0072 : by deposition from the gaseous phase, e.g. sputtering, CVD, PVD
• CPC Class Codes: B01D 67/00793 : Dispersing a component, e.g. as particles or powder, in another component
• CPC Class Codes: B01D 67/0088 : Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: B01D 67/009 : with wave-energy, particle-radiation or plasma
• CPC Class Codes: B01D 69/02 : characterised by their properties
• CPC Class Codes: B01D 69/148 : Organic/inorganic mixed matrix membranes
• CPC Class Codes: B01D 71/0221 : Group 4 or 5 metals
• CPC Class Codes: B01D 71/02231 : Palladium
• CPC Class Codes: B01D 71/02232 : Nickel
• CPC Class Codes: B82Y 30/00 : Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

An antimicrobial material comprising an antimicrobial metallic material and a biguanide polymer reacted with a crosslinker to form an adduct is described. Both freestanding antimicrobial materials and antimicrobial films are provided. The antimicrobial material does not release biocidal levels of leachables into a contacting solution.

Claims

1. A freestanding antimicrobial material, not associated with a substrate, comprising a biguanide polymer, a cross-linker reacted with the biguanide polymer to form an adduct, and an antimicrobial metal, metal salt or metal complex, wherein said metal, metal salt or metal complex forms a complex with said adduct, and wherein said antimicrobial material does not release biocidal levels of leachables into a contacting solution.

2. An antimicrobial film formed by a process comprising casting a film comprising a biguanide polymer, a cross-linker reacted with the biguanide polymer to form an adduct, and an antimicrobial metal, metal salt or metal complex, wherein said metal, metal salt or metal complex forms a complex with said adduct, under conditions sufficient to form a film and wherein said antimicrobial film does not release biocidal levels of leachables into a contacting solution.

3. The antimicrobial film of claim 2 wherein the biguanide polymer is polyhexamethylene biguanide or a polymer containing biguanide moieties.

4. The antimicrobial film of claim 2 wherein the crosslinker is an organic compound containing reactive groups selected from the group consisting of isocyanates, carboxylic acids, acid chlorides, acid anhydrides, succimidyl ethers, aldehydes, ketones, alkyl methanesulfonates, alkyl trifluoromethanesulfonates, alkyl para-toluenemethanesulfonates, alkyl halides and epoxides.

5. The antimicrobial film of claim 2 wherein the metal salt is silver iodide.

6. The antimicrobial film of claim 2 wherein the metal is silver.