Sensor, method and device for optical blood oximetry

• US 6,031,603 A
• Filed: 07/09/1998
• Issued: 02/29/2000
• Est. Priority Date: 06/09/1995
• Status: Expired due to Term

• Current Assignee: TMM Acquisitions Limited
• Original Assignee: Cybro Medical, Ltd.
• Inventors: Rapoport, Boris, Sternberg, Alexander, Goldinov, Leonid, Fine, Ilya, Katz, Yeshayahu
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US08/973,709
• Time in Patent Office: 600 Days
• Field of Search: 356/39, 356/40, 356/41, 128/633, 128/664, 128/665, 600/310, 600/314-316, 600/322-324, 600/326, 600/328, 600/340
• US Class Current: 356/41
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01N 2021/4747 Concentric bundles

Abstract

There is described a new sensor for optical blood oximetry as well as a method and apparatus in which the new sensor is used. The new sensor includes two point-like light emitters (23,24) positioned in the center of the device in close proximity to each other and at least one and preferably two annular detector terminals (32,39) concentrically surrounding the light emitters. The light sources may, for example, be two laser diodes emitting each monochromatic light within the range of 670 nm to 940 nm. The detector devices are, for example, photodetectors.

Claims

1. A sensor for noninvasive optical blood oximetry comprising:

an applicator body having a contact surface adapted for apposition in contact with a blood perfused body tissue;

first and second emitters disposed in the applicator body in close proximity to one another and arranged to emit light rays of first and second wavelengths, respectively, to irradiate a first region of the blood perfused tissue, the first wavelength being different than the second wavelength;

a first waveguide comprising a plurality of light transmitting elements, the first waveguide having proximal and distal endfaces and being disposed in the applicator block surrounding the first and second emitters so that the distal endface is arranged in apposition to a second region of the blood perfused tissue spaced apart from the first region, a portion of the light rays emitted by the first and second emitters being reflected from within the second region, the first waveguide transmitting only light rays reflected from the second region having an angle within a first predetermined range;

a first detector optically coupled to the proximal endface of the first waveguide, the first detector producing a first electrical output signal corresponding to an intensity of the light transmitted to the first detector via the first waveguide.

2. The sensor as defined in claim 1 wherein the distal endface of the first waveguide defines a frustoconical surface with respect to the plane of the second region.

3. The sensor as defined in claim 2 wherein the frustoconical surface is inclined at an angle less than 42 degrees from the plane of the second region.

4. The sensor as defined in claim 1 wherein each one of the plurality of light transmitting elements has a longitudinal axis inclined at an angle α

with respect to a plane normal to the second region and the distal endface of the first waveguide is parallel to the second region.

5. The sensor as defined in claim 4 wherein the angle α

is less than about 42 degrees.

6. The sensor as defined in claim 1 further comprising:

a second waveguide comprising a plurality of light transmitting elements, the second waveguide having proximal and distal endfaces and being disposed in the applicator block surrounding the first waveguide so that the distal endface of the second waveguide is arranged in apposition to a third region of the blood perfused tissue spaced apart from the second region, a portion of the light rays emitted by the first and second emitters being reflected from within the third region, the second waveguide transmitting only light rays reflected from the third region having an angle within a second predetermined range;

a second detector optically coupled to the proximal endface of the second waveguide, the second detector producing a second electrical output signal corresponding to the intensity of the light transmitted to the second detector via the second waveguide.

7. The sensor as defined in claim 6 wherein the distal endface of the second waveguide defines a frustoconical surface with respect to the plane of the third region.

8. The sensor as defined in claim 7 wherein the frustoconical surface is inclined at an angle less than about 42 degrees from the plane of the third region.

9. The sensor as defined in claim 6 wherein each one of the plurality of light transmitting elements has a longitudinal axis inclined at an angle α

with respect to a plane normal to the third region and the distal endface of the second waveguide is parallel to the third region.

10. The sensor as defined in claim 9 wherein the angle α

is less than about 42 degrees.

11. The sensor as defined in claim 1 wherein the first and second emitters are light sources.

12. The sensor as defined in claim 1 wherein the first and second emitters are light transmitting elements having proximal and distal ends, each one of the distal ends of the light transmitting elements being a free, light emitting end and each one of the proximal ends of the light transmitting elements being coupled to a light source.

13. The sensor as defined in claim 1 wherein the first waveguide forms an annulus arranged substantially concentrically surrounding the first and second light emitter.

14. The sensor as defined in claim 6 wherein the second waveguide forms an annulus arranged substantially concentrically surrounding the first waveguide.

15. The sensor as defined in claim 1 wherein the first and second light emitters are laser diodes each emitting monochromatic light within a range of 670-940 nm.

16. The sensor as defined in claim 15 wherein the first wavelength is in a range of 750-760 nm and the second wavelength is in a range of 780-800 nm.

17. The sensor as defined in claim 6 wherein the first and second detectors are phototdiodes.

18. The sensor as defined in claim 13 wherein the applicator block includes a portion defining an annular space that accepts the first waveguide, the first waveguide being disposed in the annular space so that its distal endface is retracted from the second region to form an annular gap between the distal endface and the second region, the annular gap serving as a collimator that rejects specular reflection from the second region.

19. The sensor as defined in claim 14 wherein the applicator block includes a portion defining an annular space that accepts the second waveguide, the second waveguide being disposed in the annular space so that its distal endface is retracted from the third region to form an annular gap between the distal endface and the third region, the annular gap serving as a collimator that rejects specular reflection from the third region.

20. A method of noninvasive optical blood oximetry in blood perfused tissues comprising:

providing an optical sensor with applicator block holding at least two light emitter terminals in close proximity to each other and at least two annular light detector terminals concentrically surrounding said at least two light emitter terminals and having a contact surface;

positioning said applicator block on a skin portion of a subject where the underlying tissues are to be investigated, with the contact surface facing the skin;

sequentially emitting from said emitter terminals light of at least two different wavelengths;

detecting the intensity of light signals arriving from the tissue under investigation by integral acquisition thereof by said at least two light detector terminals;

determining the ratios between the intensity of light detected by said at least two annular light detector terminals at each of said at least two different wavelengths; and

determining a value of oxygen saturation of the blood on the basis of such ratios.

21. The method of claim 20, wherein said detecting step comprises simultaneously detecting the intensity of said light signals by said at least two light detector terminals.

22. The method of claim 20, wherein the said light emitter terminals are each a light emitter terminal having a free, light emitting end and being coupled via another end to a light source.

23. The method of claim 22, wherein said light sources are laser diodes each emitting monochromatic light within the range of 670-940 nm.

24. The method of claim 23, wherein a first light source emits at 750-760 nm and a second at 780-800 nm.

25. The method of claim 20, wherein said at least two light detector terminals are connected to first and second light detectors, respectively, further including:

selecting two points of time for the performance of measurements, a first being a nil point of the pulsatile arterial blood component and a second the crest point thereof;

performing at each of said first and second points measurements which comprise illuminating with light of a first wavelength and simultaneously recording signals arriving from the tissue with said first and second light detectors, and subsequently illuminating with light of a second wavelength and simultaneously recording signals arriving from the tissue simultaneously with said first and second light detectors;

determining two intensity ratios for each of said two points of time, the first intensity ratio being between the light signal intensities registered by the first and second light detectors at the first wavelength, and the second intensity ratio being between the light signal intensities registered by the first and second light detectors at the second wavelength;

computing first and second pulsatile components AC1 and AC2 of the light signal for each of said first and second wavelengths, being each the difference between the intensity ratio caluclated at the crest and the nil points for the respective wavelength;

computing first and second constatn components DC1 and DC2 of the light signals for each of said first and second wavelengths, being each the average of two intensity ratios calculated at the nil and crest points for the two wavelengths; and

calculating the oxygen saturation of arterial blood SaO₂ in accordance with the following equation;

space="preserve" listing-type="equation">SaO.sub.2 =K1[(AC1×

DC2)/(DC1×

AC2)]+K2

where K1 and K2 are calibration constants.

26. An apparatus for noninvasive optical blood oximetry comprising:

a senor having a carrier body with an applicator block having a contact surface which in operation faces a blood perfused body tissue of a subject under investigation, which applicator block is fitted with at least two point like emitter terminals position in close proximity to each other and each emitting light of a wavelength distinct from that of the other, and at least two, essentially annular light detector terminals concentrically surrounding said at least two light emitter terminals, each having a free, light-acquiring end for the acquisition of light arriving from a tissue under investigation;

at least two light sources coupled to said light emitter terminals and capable of emitting light of a least two different wavelengths;

at least two optical detectors coupled to said at least two, essentially annular detector terminals;

control means adapted to cause said at least two light sources to illuminate said tissue sequentially via said emitter terminals and to obtain synchronized measurements of intensity of light acquired by said at least two detectors via said at least two detector terminals; and

processor means for determining characteristics of interest from the results of said synchronized measurements.

27. The apparatus of claim 26, wherein said control means causes said at least two detectors to simultaneously detect light signals.

28. The apparatus of claim 26, wherein said light sources are positioned within said applicator block.

29. The apparatus of claim 26, wherein each light emitter terminal has a free, light emitting end and is coupled via another end to a light source.

30. The apparatus of claim 29, wherein said light sources are laser diodes each emitting monochromatic light within the range of 670-940 nm.

31. The apparatus of claim 30, wherein a first light source emits at 750-760 nm and a second at 780-800 nm.