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Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing

  • US 6,031,930 A
  • Filed: 08/23/1996
  • Issued: 02/29/2000
  • Est. Priority Date: 08/23/1996
  • Status: Expired due to Term
First Claim
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1. A method of analyzing a tissue sample having a layer of adjacent, connected tissue cells for pre-invasive neoplasia, comprising:

  • optically and microscopically scanning the tissue sample having adjacent, connected tissue cells to provide, multiple image fields and electronically recording these image fields to provide spatially adjacent multiple image fields of the tissue sample larger than a single view of the adjacent, connected tissue cells;

    forming a reconstituted image of the suspected neoplasia tissue from the multiple, electronically recorded, spatially adjacent image fields larger than a single field of view and having adjacent connected tissue cells in the reconstituted image;

    displaying to the viewer the reconstituted tissue image comprised of multiple, spatially adjacent image fields larger than a single field of view;

    determining and selecting from the reconstituted, tissue image a region of adjacent connected tissue cells for analysis at a resolution; and

    analyzing tissue sample images of the selected region at the resolution for the analysis of pre-invasive neoplasia.

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