Device for the detection of analyte and administration of a therapeutic substance

• US 6,032,059 A
• Filed: 07/22/1997
• Issued: 02/29/2000
• Est. Priority Date: 12/19/1995
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Elstrom, Tuan A., Henning, Timothy P., Shain, Eric B., Khalil, Gamal
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US08/898,209
• Time in Patent Office: 952 Days
• Field of Search: 604/19, 604/27-28, 604/30-45, 604/49, 604/51, 604/131, 604/133, 604/134, 604/140, 604/141, 604/890.1, 604/891.1, 128/DIG. 12, 128/898, 600/345
• US Class Current: 600/345
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles

Abstract

The present invention relates to a device for the sampling of blood or other body fluids which includes means for the direct measurement of the analyte of interest within the fluid. Also disclosed is a `closed-loop` device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient'"'"'s body.

Claims

1. A device for delivering a drug directly to the body of a patient, comprising:

(a) a needle for taking us blood or other body fluid from a patient by means of capillary action or other hydrodynamic forces or by means of both capillary action and other hydrodynamic forces;

(b) a sensor included in the needle, which sensor detects an analyte of interest or concentration thereof in the blood or other body fluid;

(c) an analysis means for receiving and processing a signal from the sensor and sending a signal representative of the analyte of interest or the concentration thereof to (d) a control device for transmitting a signal to an injection actuator; and

(e) an injector for delivering the required amount of the drug in response to the injection actuator via the needle.

2. The device of claim 1 wherein the control device includes a user input for determining the required amount of the drug to be injected.

3. The device of claim 1 wherein the control device includes an analytical method for determining the required amount of the drug to be injected.

4. The device of claim 3 wherein the analytical method is an algorithm.

5. A method of delivering a drug directly to the body of a patient, comprising:

(a) providing (1) a needle, which needle is capable of taking up blood or other body fluid from a patient by means of capillary action or other hydrodynamic forces or by means of both capillary action and other hydrodynamic forces;

(2) a sensor included in the needle, which sensor detects an analyte of interest or concentration thereof in the blood or other body fluid;

(3) an analysis means for receiving and processing a signal from the sensor and sending a signal representative of the analyte of interest or the concentration thereof to a control device for transmitting a signal to an injection actuator;

(b) providing a drug delivery device which comprises the control device for transmitting a signal to the injection actuator, and an injector for delivering the required amount of the drug in response to the injection actuator via the needle;

(c) introducing the needle into the patient; and

(d) delivering the required drug dosage in response to the injection actuator.