Method for enhancing and separating biopotential signals

• US 6,032,072 A
• Filed: 01/30/1998
• Issued: 02/29/2000
• Est. Priority Date: 01/30/1998
• Status: Expired due to Term

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Aspect Medical Systems, Inc. (Medtronic Plc)
• Inventors: Greenwald, Scott D., Smith, Charles P., Devlin, Philip H.
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US09/016,104
• Time in Patent Office: 760 Days
• Field of Search: 606/544, 606/546, 606/509, 606/383, 606/391, 606/393, 606/394, 606/396, 606/397
• US Class Current: 600/544
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

Disclosed is an electrode array (i.e., "sensor") and a method for separating near and far-field signals. In one embodiment a horizontal array is used, and in an alternate embodiment a vertical array is used. The electrode array consists of two well-separated pairs of closely spaced electrodes (and a separate ground element). In a typical application of collecting a channel of EEG, "sensing" electrodes are placed in standard locations (e.g., R and Ctr) with a ground electrode placed elsewhere on the head. The voltage measured between the well-separated sensing electrodes is the far-field dominant (i.e., EEG-dominant) channel. Additional electrodes are placed near each of the two sensing electrodes. (The additional electrodes are immediately lateral to the existing electrodes in the horizontal array, and are immediately above the existing electrodes in the vertical array.) The voltages measured between the pairs of closely spaced electrodes are near-field dominant (i.e., EMG/EOG-dominant) channels. The EEG, EMG and EOG signals can be enhanced by uncoupling them by combining information from all channels. The sensor is connected to a monitor via a patient interface cable (PIC). The sensor contains additional circuitry at the connection site that is used by the monitor to identify the presence and type of sensor, and to configure the monitor to invoke the appropriate software that will apply the method of the current invention to collect and uncouple the EEG, EMG and EOG.

Claims

1. A method of uncoupling and enhancing near-field and far-field biopotential signals using an electrode array including one pair of closely positioned electrode elements, at least one other electrode element widely spaced from said pair of closely positioned elements and a ground element, said method comprising the steps of:

collecting two or more input signals from said electrode elements;

deriving one or more near-field dominant signals from said input signals collected through two electrodes of said pair of closely positioned electrode elements and deriving at least one far-field dominant signal from said input signals collected through two of said widely-spaced electrode elements;

creating estimates of relationships among the near-field and far-field dominant signals.

2. The method of claim 1 wherein the step of deriving near-field dominant signals comprises deriving near-field dominant signals as measured voltages across said pair of said closely positioned electrode elements.

3. The method of claim 1 wherein the step of deriving one far-field dominant signal comprises deriving a far-field dominant signal as the measured voltage across two widely-spaced electrode elements.

4. The method of claim 1 further comprising the step of segmenting said near-field dominant signals and said far-field dominant signals into a sequence of finite epochs.

5. The method of claim 4 wherein the step of segmenting said near-field dominant signal and said far-field dominant signals comprises segmenting said signals into overlapping, 2-second epochs.

6. The method of claim 1 wherein the step of creating estimates of relationships among the near-field and far-field dominant signals comprises the step of estimating the power spectra of each near-field and far-field dominant signal and of the cross spectra between each pair of near-field and far-field dominant signals.

7. The method of claim 1 wherein the step of creating estimates of relationships among the near-field and far-field dominant signals comprises determining the coherence between each far-field dominant signal with a near-field dominant signal.

8. The method of claim 4 further comprising a step of uncoupling near-field and far-field components from the signals within an epoch, said step of uncoupling comprising the steps of:

attenuating the power at each frequency of the far-field dominant signal in the epoch by weighting each frequency component of a Fourier Transformation of said epoch by a first function of coherences between said far-field dominant signal with each of said near-field dominant signals;

attenuating the power at each frequency of a near-field dominant signal in the epoch by weighting each frequency component of the Fourier Transformation of the epoch by a second function of the coherences between each of said near-field dominant signal with said far-field dominant signal.

9. The method of claim 8 further comprising the step of constructing output near-field signals from said uncoupled near-field components and far-field signals from said far-field components.

10. The method of claim 9 wherein said step of constructing the output near-field and far-field signals from the epochs comprises the steps of:

creating an output far-field signal from the far-field dominant signal by transforming a weighted spectra of the epoch back into the time domain using an inverse Fourier Transformation of said epoch to create a first transformed epoch and outputing samples within the transformed epoch that correspond to a time since the last output sample and a beginning of a next overlapping epoch;

creating an output near-field signal from the far-field dominant signal by transforming a weighted spectra of the epoch back into the time domain using an inverse Fourier Transformation of said epoch to create a second transformed epoch and subtracting said time domain signal in said second transformed epoch from said far-field dominant signal;

outputing samples within said second transformed epoch that correspond to a time since an immediately prior output sample and a beginning of a next overlapping epoch.

11. The method of claim 1 wherein said near-field dominant signals are EOG-dominant signals.

12. The method of claim 1 wherein said near-field dominant signals are EMG-dominant signals.

13. The method of claim 1 further comprising the step of using said estimates of relationships to uncouple near-field components from far-field components of said input signals.

14. A method of uncoupling and enhancing near-field and far-field biopotential signals using an electrode array comprising one pair of closely positioned electrode elements and at least one other electrode element widely spaced from said pair of closely positioned electrode elements and a ground element, said method comprising the steps of:

deriving a first far-field dominant signal from one of said pair of closely positioned electrode elements and said widely spaced electrode element;

deriving a second far-field dominant signal from a second electrode element of said pair of closely positioned electrode elements and said widely-spaced electrode element;

deriving one near-field dominant signal by subtracting said first far-field dominant signal from said second far-field dominant signal.

15. A method of uncoupling and enhancing near-field and far-field biopotential signals using an electrode array comprising one pair of closely positioned electrode elements, at least one other electrode element widely spaced from said pair of closely positioned electrode elements and a ground element, said method comprising the steps of:

deriving one or more near-field dominant signals through two electrodes of said pair closely positioned electrode elements and at least one far-field dominant signal through two of said widely spaced electrode elements;

determining relationships between said near-field dominant signals and said far-field dominant signals; and

uncoupling near-field components from far-field components in said biopotential signals.

16. An electrode array for acquiring electrical biopotential signals from a recording surface on a living body comprising:

two or more electrode elements positioned in a third dimension from the recording surface;

a spacer positioned between each two adjacent electrode elements for separating each electrode element from the other electrode elements.

17. The electrode array of claim 16 wherein said two or more electrodes and said spacers are encased in a housing.

18. The electrode array of claim 17 wherein said housing is filled with a conductive substance.

19. The electrode array of claim 18 wherein the conductive substance is a solid hydrogel.

20. The electrode array of claim 18 wherein the conductive substance is a liquid gel.

21. The electrode array of claim 16 wherein said electrode elements are connected to a data acquisition device via lead wires through an electrically isolated snap.

22. An electrode array for acquiring electrical biopotential signals from a recording surface on a living body comprising:

a first electrode element and a second electrode element positioned on a single substrate, the center of said first electrode element being separated from the center of said second electrode element by no more than 2.5 inches;

a third electrode element positioned on said single substrate, the center of said third electrode element being separated from the center of said first electrode element by between 2.5 inches and 12 inches.