Iontophoretic transdermal system for the administration of at least two substances

• US 6,032,073 A
• Filed: 12/15/1997
• Issued: 02/29/2000
• Est. Priority Date: 04/07/1995
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Novartis Ag
• Inventors: Effenhauser, Carlo Stefan
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): KENNEDY, SHARON E
• Application Number:
  US08/930,720
• Time in Patent Office: 806 Days
• Field of Search: 604/20, 604/19, 604/289, 604/890.1, 607/115, 607/120, 607/152, 607/153
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0428 Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

A transdermal system (1) for the administration of at least two substances through the skin with the aid of an electric current has a reservoir, which comprises a storage layer (2) for the substances, and a transfer means, which may be arranged in the form of a separating layer (3), that is connected to both the reservoir and the patient'"'"'s skin (5) during administration. The transdermal system also has electrodes (4) which generate a current that transports the substances from the reservoir into the skin (5). In the transdermal system (1) means for the physical separation of the substances are provided that render possible a sequential administration of the substances.

Claims

1. A transdermal system (1) for the administration of at least two substances through the skin with the aid of an electric current, the transdermal system (1) comprising:

(a) a reservoir having a storage layer (2) and containing at least two substances,

(b) transfer means connected to said reservoir and adapted to be connected to the skin (5) during administration, the transfer means comprising a separating layer (3) adapted to physically separate the substances from one another as they pass through the separating layer (3); and

(c) electrodes (4) adapted to generate a current to transport the substances from the reservoir through the transfer means into the skin (5).

2. A transdermal system of claim 1, wherein the different substances are present in the storage layer (2) in an electrically charged form, the polarity of the electric charge being the same for the different substances.

3. A transdermal system of claim 1, wherein the different substances are contained in the storage layer (2) in an electrically charged form, the polarity of the electric charge being different for the different substances.

4. A transdermal system of claim 1, wherein the electrical conductivity of the separating layer (3) is different from that of the storage layer (2).

5. A transdermal system of claim 4 wherein the electrical conductivity of the separating layer (3) is higher than that of the storage layer (2).

6. A transdermal system of claim 1, wherein the separating layer (3) comprises a polymer material, a gel, or a hydrogel.

7. A transdermal system of claim 1, wherein the storage layer (2) comprises a polymer material, a gel, or a hydrogel.

8. A transdermal system of claim 1, wherein there is provided at least at one electrode (4) an intermediate layer (4a) which is adjacent to said electrode (4) and which is adapted to keep electrolytic products away from the storage layer (2) and from the skin.

9. A transdermal system of claim 1, wherein there is provided between the storage layer (2) and the separating layer (3) a blocking membrane (15) the permeability of which can be altered by means of an electric field.

10. A transdermal system of claim 1, wherein the reservoir comprises at least a first storage layer (11) and a second storage layer (13) that are substantially separated from one another physically, each layer containing at least one substance.

11. A transdermal system of claim 10, wherein there is provided between the storage layers (11, 13) a modification layer (12) which physically separates the storage layers (11, 13) from one another.

12. A transdermal system of claim 11, wherein the transfer means comprises a second modification layer (10) which is in physical communication with that storage layer (11) of the reservoir adapted to be closest to the skin (5).

13. A transdermal system of claim 12, wherein the electrical conductivity of the modification layers (10, 12) is different from that of the storage layers (11, 13).

14. A transdermal system of claim 13 wherein the electrical conductivity of the modification layers (10, 12) is higher than that of the storage layers (11, 13).

15. A transdermal system of claim 10, wherein the storage layers (11, 13) comprise a polymer material, a gel, or a hydrogel.

16. A transdermal system of claim 12, wherein the modification layers (10, 12) comprise a polymer material, a gel, or a hydrogel.

17. A transdermal system of claim 10, wherein there is provided at least at one electrode (4) an intermediate layer (4a) which is adjacent to said electrode and which is adapted to keep electrolytic products away from at least one of the storage layers (11, 13) and from the skin.

18. A transdermal system of claim 12, wherein there are provided between adjacent modification layers (10, 12) and storage layers (11, 13) blocking membranes (15) the permeability of which can be altered by means of an electric field.