Method of assessing reperfusion after thrombolytic therapy
First Claim
1. A method of determining if reperfusion has occurred in a myocardial infarct patient after receiving thrombolytic therapy, comprising:
- (a) detecting a first variable comprising a first serum creatine kinase MB level in a myocardial infarct patient undergoing thrombolytic therapy at the an onset of said thrombolytic therapy;
then(b) detecting a second variable comprising a second creatine kinase MB level in said patient a predetermined time after the onset of said thrombolytic therapy; and
(c) detecting a third variable comprising a presence or absence of chest pain a predetermined time after the onset of said thrombolytic therapy;
(d) detecting a fourth variable comprising a serum myoglobin level in said patient a predetermined time after the onset of said thrombolytic therapy;
(e) generating a probability of the presence of a persistent occlusion from said first through fourth variables, the absence of a persistent occlusion indicating that reperfusion has occurred in said patient.
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Abstract
The present invention is a method of diagnosing the presence of a persistent occlusion in a myocardial infarct patient undergoing thrombolytic therapy. The method comprises detecting a series of five variables from the patient and then generating the probability of the presence of a persistent occlusion from those variables. The first variable comprises a serum creatine kinase MB (CK-MB) level from a patient at the onset of thrombolytic therapy. The second variable comprises a second CK-MB level in the patient at a predetermined time after the onset of thrombolytic therapy. The third variable comprises the presence or absence of chest pain a predetermined time after the onset of thrombolytic therapy. The fourth variable comprises the serum myoglobin level in the patient at a predetermined time after the onset of thrombolytic therapy. In a preferred embodiment of the present invention, the second, third and fourth variables are detected within 30 minutes of each other and within about 1 to about 3 hours after the initial variable is detected. In an alternate embodiment a fifth variable reflecting the time from onset of chest pain to the beginning of thrombolytic therapy is included in the regression model.
21 Citations
13 Claims
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1. A method of determining if reperfusion has occurred in a myocardial infarct patient after receiving thrombolytic therapy, comprising:
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(a) detecting a first variable comprising a first serum creatine kinase MB level in a myocardial infarct patient undergoing thrombolytic therapy at the an onset of said thrombolytic therapy;
then(b) detecting a second variable comprising a second creatine kinase MB level in said patient a predetermined time after the onset of said thrombolytic therapy; and (c) detecting a third variable comprising a presence or absence of chest pain a predetermined time after the onset of said thrombolytic therapy; (d) detecting a fourth variable comprising a serum myoglobin level in said patient a predetermined time after the onset of said thrombolytic therapy; (e) generating a probability of the presence of a persistent occlusion from said first through fourth variables, the absence of a persistent occlusion indicating that reperfusion has occurred in said patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of determining if reperfusion has occurred in a myocardial infarct patient after receiving thrombolytic therapy, comprising:
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(a) detecting a first variable comprising a first serum creatine kinase MB level in a myocardial infarct patient undergoing thrombolytic therapy at an onset of said thrombolytic therapy;
then(b) detecting a second variable comprising a second creatine kinase MB level in said patient a predetermined time after the onset of said thrombolytic therapy; and (c) detecting a third variable comprising a presence or absence of chest pain a predetermined the after the onset of said thrombolytic therapy; (d) detecting a fourth variable comprising a serum myoglobin level in said patient a predetermined time after the onset of said thrombolytic therapy; (e) detecting a fifth variable comprising a time from onset of myocardial infarct symptoms in said patient to an administration of the thrombolytic therapy to said patient; (f) generating a probability of the presence of a persistent occlusion from said first through fifth variables, the absence of a persistent occlusion indicating that reperfusion has occurred in said patient; wherein said first variable is detected within about 6 hours from an onset of symptoms in the patient and within about 1 hour of the onset of thrombolytic therapy; wherein said second variable, said third variable and said fourth variable are detected within thirty minutes of one another; and wherein said second variable, said third variable and said fourth variable are detected from 1 to 3 hours after the onset of thrombolytic therapy. - View Dependent Claims (10, 11, 12, 13)
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Specification