Apparatus and method for vasodilation

• US 6,033,371 A
• Filed: 08/26/1997
• Issued: 03/07/2000
• Est. Priority Date: 10/03/1991
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Torre, Ralph De La, Gregory, Kenton W.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/920,142
• Time in Patent Office: 924 Days
• Field of Search: 601/2, 601/15, 606/2, 606/3, 606/13-16, 606/128, 606/191, 606/194, 606/2.5, 607/88, 607/89, 600/439
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/22022 using electric discharge
• CPC Class Codes: A61B 18/26 for producing a shock wave, e.g. laser lithotripsy
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: Y10S 977/905 Specially adapted for travel through blood circulatory system
• CPC Class Codes: Y10S 977/951 Laser

Abstract

A method and apparatus for dilating blood vessels in vasospasm through the use of high frequency wave, e.g., hydraulic or acoustic waves. The invention is suitable to treat any vasospasm, including any vasospasm intractable to medication, including cerebral vasospasm, which currently is not susceptible to any mechanical or chemical treatments. The apparatus for dilating blood vessels includes a catheter having a fluid-filled lumen, a wave generator arranged within the catheter lumen for generating a wave front that propagates through the fluid in the lumen and is transmitted from the distal end of the catheter to propagate through the fluid in the blood vessel, and an energy source connected to the wave generator to provide energy to produce the wave front.

Claims

1. A method of opening an occluded blood vessel filled with a first fluid, the method comprising the steps of:

inserting a catheter into the blood vessel, the catheter comprising a lumen containing a second fluid, wherein the first and second fluids can be the same or different, and wherein a distal end of the lumen is covered with a membrane that separates the first and second fluids,

generating a hydraulic wave front in the second fluid in the lumen,

propagating the wave front through the second fluid in the lumen,

transmitting the wave front from the distal end of the lumen and into the vessel by way of the membrane, and

propagating the transmitted wave front through the first fluid in the blood vessel to open the occluded blood vessel.

2. The method of claim 1, wherein the wave front is generated by laser pulses communicated through an optical fiber into the lumen and absorbed by the second fluid.

3. The method of claim 2, wherein the laser pulses produce a cavitation bubble within the lumen.

4. The method of claim 2, wherein the laser pulses produce a vaporization bubble within the lumen.

5. The method of claim 1, wherein the blood vessel being opened is in vasospasm and propagating the transmitted wave front through the first fluid opens the occluded blood vessel by inducing vasodilation.

6. The method of claim 1, wherein the wave front is generated by laser pulses communicated through an optical fiber into the lumen and absorbed by the second fluid to produce a bubble within the lumen without forming a bubble within the blood vessel outside of the lumen.

7. The method of claim 6, wherein each of the laser pulses has a duration of less than 300 microseconds.

8. The method of claim 6, wherein the wave front is generated without generating a laser breakdown-induced shock wave.

9. The method of claim 1, wherein the wave front is generated by a spark, ultrasound energy, or piezoelectric agitation.

10. The method of claim 1, wherein the first and second fluids are different.

11. A method of opening an occluded blood vessel filled with a first fluid, the method comprising the steps of:

inserting a catheter into the blood vessel, the catheter comprising a lumen containing a second fluid, wherein the first and second fluids can be the same or different,

generating a hydraulic wave front in the second fluid in the lumen, wherein the wave front is generated by a non-laser wave generator,

propagating the wave front through the second fluid in the lumen,

transmitting said wave front from the distal end of the lumen, and

propagating the transmitted wave front through the first fluid in the blood vessel to open the occluded blood vessel.

12. The method of claim 11, wherein the distal end of the lumen is open and the wave front is transmitted from the distal end of the lumen by exiting the lumen and passing into the vessel.

13. The method of claim 11, wherein the distal end of the lumen is covered with a membrane that separates the first and second fluids, and wherein the wave front is transmitted into the vessel from the distal end of the lumen by way of the membrane.

14. The method of claim 11, wherein the blood vessel being opened is in vasospasm and propagating the transmitted wave front through the first fluid opens the occluded blood vessel by inducing vasodilation.

15. The method of claim 11, wherein the wave front is generated without generating a shock wave.

16. The method of claim 11, wherein the wave front is generated by a spark, ultrasound energy, or piezoelectric agitation.

17. An apparatus for opening an occluded blood vessel filled with a first fluid, comprising:

a catheter comprising a lumen containing a second fluid, wherein the first and second fluids can be the same or different,

a wave generator arranged within the lumen for generating a hydraulic wave front that propagates through the second fluid in the lumen and is transmitted from a distal end of the lumen to propagate through the first fluid in the blood vessel, wherein the distal end of the lumen is sealed with a membrane and the wave front is transmitted from the distal end of the lumen via the membrane, and wherein said wave generator is controlled and located a distance from the distal end of the lumen such that no shock wave is propagated in the blood vessel, and

an energy source connected to the wave generator to provide energy to generate the wave front.

18. The apparatus of claim 17, wherein the wave generator includes a radiation-transmitting fiber medium with one end terminating within the lumen and another end being optically connected with the energy source, wherein the energy source is a source of radiation.

19. The apparatus of claim 18, wherein the energy source includes a laser.

20. The apparatus of claim 19, wherein the laser provides electromagnetic radiation in repetitive pulses, each of which has a duration of less than 300 micro-seconds.

21. The apparatus of claim 18, wherein the radiation from the energy source is provided within the lumen and is absorbed by the second fluid, and wherein the one end of the radiation-transmitting fiber medium is positioned within the lumen to cause a bubble to be formed within the lumen as a source of the wave front.

22. The apparatus of claim 21, wherein the source of radiation includes a laser.

23. The method of claim 17, wherein the wave front is generated by a spark, ultrasound energy, or piezoelectric agitation.

24. The apparatus of claim 17, wherein the first and second fluids are different.

25. An apparatus for opening an occluded blood vessel filled with a first fluid, comprising:

a catheter comprising a lumen containing a second fluid, wherein the first and second fluids can be the same or different,

a non-laser wave generator arranged within the lumen for generating a hydraulic wave front that propagates through the second fluid in the lumen and is transmitted from a distal end of the lumen to propagate through the first fluid in the blood vessel, wherein the wave generator is controlled and located a distance from the distal end of the lumen such that no shock wave is propagated in the blood vessel, and

an energy source connected to the wave generator to provide energy to produce the wave front.

26. The apparatus of claim 25, wherein the distal end of the lumen is open and the wave front is transmitted from the distal end of the lumen by exiting the lumen and passing into the vessel.

27. The apparatus of claim 25, wherein the distal end of the lumen is sealed with a membrane and the wave front is transmitted from the distal end of the lumen via the membrane.

28. The method of claim 25, wherein the wave front is generated by a spark, ultrasound energy, or piezoelectric agitation.

29. An apparatus for opening an occluded blood vessel filled with a first fluid, comprising:

a catheter comprising a lumen containing a second fluid, wherein the first and second fluids can be the same or different,

a wave generator arranged within the lumen for generating a hydraulic wave front that propagates through the second fluid in the lumen and is transmitted from a distal end of the lumen to propagate through the first fluid in the blood vessel, wherein the distal end of the lumen is sealed with a membrane and said wave front is transmitted from the distal end of the lumen through the membrane, and wherein the wave generator includes an optical fiber having an end terminating within the lumen, and

a source of electromagnetic radiation operably connected to another end of the optical fiber and having a wavelength that is absorbed by the second fluid in a manner to create a bubble within the lumen that generates the hydraulic wave front.

30. The apparatus of claim 29, wherein the wave generator is configured and the radiation source is controlled such that no shock wave is propagated in the first fluid.

31. The apparatus of claim 29, wherein the first and second fluids are different.