Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
First Claim
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1. A microfluidic device, comprising:
- a body having disposed therein;
at least first, second, third and fourth channels communicating at a first channel intersection;
at least first, second, third, and fourth reservoirs; and
wherein the first channel connects the first reservoir to the first channel intersection, the second channel connects the second reservoir to the first channel intersection, the third channel connects the third reservoir to the first channel intersection, and the fourth channel connects the fourth reservoir to the first channel intersection; and
at least first, second, third and fourth electrodes disposed in separate electrical contact with each of the first, second, third, and fourth reservoirs, respectively, but not disposed in the channels, at least the first, second, and third electrodes simultaneously having a controlled electrical potential associated therewith.
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Abstract
A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.
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Citations
112 Claims
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1. A microfluidic device, comprising:
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a body having disposed therein; at least first, second, third and fourth channels communicating at a first channel intersection; at least first, second, third, and fourth reservoirs; and wherein the first channel connects the first reservoir to the first channel intersection, the second channel connects the second reservoir to the first channel intersection, the third channel connects the third reservoir to the first channel intersection, and the fourth channel connects the fourth reservoir to the first channel intersection; and at least first, second, third and fourth electrodes disposed in separate electrical contact with each of the first, second, third, and fourth reservoirs, respectively, but not disposed in the channels, at least the first, second, and third electrodes simultaneously having a controlled electrical potential associated therewith. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A microfluidic device, comprising:
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a body having disposed therein; at least first, second, third and fourth channels communicating at at least a first intersection; at least first, second, third and fourth reservoirs; and wherein the first channel connects the first reservoir to at least a first intersection, the second channel connects the second reservoir to the at least first intersection, the third channel connects the third reservoir to the at least first intersection and the fourth channel connects the fourth reservoir to the at least first intersection; and a plurality of electrodes in electrical contact with the channels, wherein the electrical contact consists of a separate electrode disposed in each of the at least first, second, third and fourth reservoirs, wherein at least three of the plurality of electrodes simultaneously have an electrical potential associated therewith.
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67. A microfluidic device, comprising:
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a body having disposed therein; at least first, second, third, fourth and fifth channel communicating at at least a first intersection; at least first, second, third, fourth and fifth reservoirs; and wherein the first channel connects the first reservoir to at least a first intersection, the second channel connects the second reservoir to the at least first intersection, the third channel connects the third reservoir to the at least first intersection, the fourth channel connects the fourth reservoir to the at least first intersection, and the fifth channel connects the fifth reservoir to the at least first intersection; and a plurality of electrodes in electrical contact with the channels, wherein the electrical contact consists of a separate electrode disposed in each of the at least first, second, third, fourth and fifth reservoirs, wherein at least three of the plurality of electrodes simultaneously have an electrical potential associated therewith. - View Dependent Claims (68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112)
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90. A microfluidic device, comprising:
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a body having disposed therein; at least first, second, third and fourth channel communicating at a first channel intersection; at least first, second, third and fourth reservoirs; and wherein the first reservoir is in fluid communication with the first intersection via the first channel, the second reservoir is in fluid communication with the first intersection via the second channel, the third reservoir is in fluid communication with the first channel intersection via the third channel, and the fourth reservoir is in fluid communicating with the first channel intersection via the fourth channel; and at least first, second, third and fourth electrodes disposed in separate electrical contact with each of the first, second, third, and fourth reservoirs, respectively, but not disposed in the channels, at least the first, second, and third electrodes simultaneously having a controlled electrical potential associated therewith. - View Dependent Claims (91, 92, 93, 94, 95, 96, 97, 98)
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Specification