Ultrasonic processes and circuits for performing them

• US 6,034,922 A
• Filed: 01/12/1999
• Issued: 03/07/2000
• Est. Priority Date: 09/01/1988
• Status: Expired due to Fees

• Current Assignee: Bayer Schering Pharma AG (Bayer AG)
• Original Assignee: Schering Ag (Merck & Co., Inc.)
• Inventors: Fritzsch, Thomas, Siegert, Joachim, Uhlendorf, Volkmar
• Primary Examiner(s): Pihulic, Daniel T.
• Application Number:
  US09/228,972
• Time in Patent Office: 420 Days
• Field of Search: 367/7, 367/11, 367/138, 900/458, 424/9.52
• US Class Current: 367/7
• CPC Class Codes: A61B 8/00 Diagnosis using ultrasonic, sonic or infrasonic waves imaging of objects using sonar G01S15/00
• CPC Class Codes: G01N 2291/02491 Materials with nonlinear acoustic properties
• CPC Class Codes: G01S 15/8979 Combined Doppler and pulse-echo imaging systems
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target

Abstract

A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.

Claims

1. A process for imaging an examination area containing an ultrasonic contrast agent, which comprises:

subjecting the examination area to ultrasonic energy of two different excitation frequencies, and imaging the examination area by detecting a signal including reflected and/or backscattered signals generated by non-linearity in the examination area.

2. The process of claim 1, wherein the examination area is subjected to the excitation frequencies in a broad bandwith.

3. The process of claim 1, wherein the ultrasonic contrast agent contains microbubbles or produces microbubbles upon exposure to ultrasonic energy.

4. The process according to claim 1, wherein the ultrasonic contrast agent is a solution, an emulsion or a suspension.

5. The process according to claim 4, wherein the contrast agent is a microbubble suspension having a concentration of from 10^-3 % by weight to 30% by weight dry substance in the suspension.

6. The process of claim 1, wherein the reflected and/or backscattered signal is processed with computer-controlled gate circuit, at least one time window is selected and the associated frequency spectrum is determined in analog or digital manner.

7. The process of claim 1, wherein the examination area imaged is biological tissue.

8. A process for imaging an examination area containing an ultrasonic contrast agent, which comprises:

subjecting the examination area to ultrasonic energy of frequency, f_o, and imaging the examination area using reflected and/or backscattered signals generated by non-linearity of the contrast agent, which signals are frequency-shifted from the frequency, f_o.

9. The process of claim 8, wherein the examination area is subjected to ultrasonic energy in a broad bandwidth.

10. The process of claim 8, wherein the ultrasonic contrast agent contains microbubbles or produces microbubbles upon exposure to ultrasonic energy.

11. The process according to claim 8, wherein the ultrasonic contrast agent is a solution, an emulsion or a suspension.

12. The process according to claim 11, wherein the contrast agent is a microbubble suspension having a concentration of from 10^-3 % by weight to 30% by weight dry substance in the suspension.

13. The process of claim 8, wherein the frequency f_o is 1 MHZ to 11 MHZ and 1 to 5 cycles are generated.

14. The process of claim 8, wherein the reflected and backscattered ultrasonic signal is processed with a computer-controlled gate circuit, at least one time window is selected and the associated frequency spectrum being determined in analog or digital manner.

15. The process of claim 8, wherein the examination area imaged is biological tissue.

16. A process for imaging an examination area containing an ultrasonic contrast agent, which comprises:

subjecting the examination area to ultrasonic energy of frequency, f_o, and imaging the examination area using reflected and/or backscattered signals generated by non-linearity of the contrast agent.

17. The process of claim 16, wherein the examination area is subjected to ultrasonic energy in a broad bandwidth.

18. The process of claim 16, wherein the examination area imaged is biological tissue.

19. A process for imaging a patient to whom an ultrasonic contrast agent has been administered, which comprises:

subjecting the patient to ultrasonic energy and imaging the patient using reflected and/or backscattered signals generated by non-linearity of the contrast agent.

20. The process of claim 19, wherein the patient is subjected to ultrasonic energy in a broad bandwidth.

21. The process of claim 20, wherein the ultrasonic energy has a frequency of from 0.3 MHZ to 22 MHZ.

22. The process of claim 19, wherein the patient is a human.

23. The process of claim 19, wherein the ultrasonic contrast agent contains microbubbles or produces microbubbles upon exposure to ultrasonic energy.

24. The process according to claim 19, wherein the ultrasonic contrast agent is a solution, an emulsion or a suspension.

25. The process according to claim 24, wherein the contrast agent is a microbubble suspension having a concentration of from 10^-3 % by weight to 30% by weight dry substance in the suspension.

26. The process of claim 19, wherein the ultrasonic energy has a frequency from 1 MHZ to 11 MHZ and 1 to 5 cycles are generated.

27. The process of claim 19, wherein the reflected and backscattered ultrasonic signal is processed with a computer-controlled gate circuit, at least one time window being selected and the associated frequency spectrum being determined in analog or digital manner.