Implantable medical device responsive to heart rate variability analysis

• US 6,035,233 A
• Filed: 01/09/1998
• Issued: 03/07/2000
• Est. Priority Date: 12/11/1995
• Status: Expired due to Fees

• Current Assignee: Intermedics Incorporated
• Original Assignee: Intermedics Incorporated
• Inventors: Schroeppel, Edward A., Prutchi, David, Routh, Andre G.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/005,194
• Time in Patent Office: 788 Days
• Field of Search: 600/515, 600/516, 600/518
• US Class Current: 600/515
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A method and apparatus for evaluating heart rate variability of the heart of a person in order to forecast a cardiac event. A cardiac stimulator receives heart beat signals from the heart and determines a measurement of heart rate variability based on statistical data derived from the heart beat signals and sensing data derived from a sensor. This measurement of heart rate variability is compared with previously stored heart rate variability zones defining normal and abnormal heart rate variability. These zones are modifiable after the occurrence of a cardiac event. Once a cardiac event is detected, a pathway is computed which extends from a generally normal heart rate variability condition to an abnormal heart rate variability condition. Subsequent measurements of heart rate variability are compared with this pathway. Selective therapy regimes are initiated depending on the measurement of heart rate variability.

Claims

1. A method, comprising:

defining an abnormal heart rate variability zone;

receiving a first series of heart beat signals during a first time period, where the first time period has a first predetermined length of time;

computing said heart beat signals into a first measurement of heart rate variability;

comparing said first measurement of heart rate variability with said abnormal heart rate variability zone; and

modifying said abnormal heart rate variability zone to include said first measurement of heart rate variability if a cardiac anomaly is detected during said first time period.

2. The method of claim 1 further comprising:

receiving a second series of heart beat signals during th second time period, where the second time period has a second predetermined length of time and occurs after the first time period;

computing said second heart beat signals into a second measurement of heart rate variability;

comparing said second measurement of heart rate variability with said modified abnormal heart rate variability zone if said cardiac anomaly is detected during said first time period, otherwise comparing said second measurement of heart rate variability with said abnormal heart rate variability zone;

detecting in the second series of heart beat signals another cardiac anomaly; and

modifying said modified abnormal heart rate variability zone to include said second measurement of heart rate variability if another cardiac anomaly is detected during said second time period.

3. The method of claim 1 further comprising:

dividing said abnormal heart rate variability zone to include a plurality of abnormal heart rate variability subzones;

designating a therapy regime for each of said subzones;

where comparing said first measurement of heart rate variability includes comparing the first measurement of heart rate variability with each of said subzones; and

initiating one of said therapy regimes if one of said subzones includes said first measurement of heart rate variability.

4. The method of claim 1, including gathering sensor measurements;

and

deriving first measurement of heart rate variability from statistical data derived from said heart beat signals and sensing data derived from sensor measurements.

5. The method of claim 4, where deriving first measurement of heart rate variability from statistical data includes calculating one of a measure of central tendency and a measure of deviation;

and

where deriving first measurement of heart rate variability from sensing data incudes measuring one of;

evoked QT intervals, respiration, stroke volume, central venous oxygen saturation, right ventricular pressure, blood pressure, impedance, muscle noise, acceleration, activity, temperature, blood pH, and adrenaline.

6. The method of claim 2, where analyzing the first series of heart beat signals for the cardiac anomaly includes evaluating the first series of heart beat signals for an abnormal fluctuation of sinus rhythm of said heart beat signals.

7. The method of claim 2 further comprising:

storing in a memory said abnormal heart rate variability zone, where said abnormal heart rate variability zone includes limits;

determining whether said first measurement of heart rate variability is outside limits of said abnormal heart rate variability zone;

modifying said abnormal heart rate variability zone to include said first measurement of heart rate variability when said first measurement of heart rate variability is outside limits of said abnormal heart rate variability zone; and

storing in memory said modified abnormal heart rate variability zone.