Electrotransport delivery device with voltage boosting circuit

• US 6,035,234 A
• Filed: 09/29/1997
• Issued: 03/07/2000
• Est. Priority Date: 06/02/1995
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: McNichols, Larry A., Badzinski, John D., Riddle, Thomas A.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/939,921
• Time in Patent Office: 890 Days
• Field of Search: 604/20-21, 604/501, 604/503, 607/149, 607/152, 607/62
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

An electrotransport device (10) for delivering therapeutic agents includes an adjustable voltage boost multiple controller (100, 200) for boosting the voltage from a power source (102, 202) to a working voltage V_w having a value just sufficient to provide the desired therapeutic current level I_I through the electrodes (108, 112), at least one of which contains the therapeutic agent to be delivered.

Claims

1. A control circuit for use with an electrotransport delivery device, said delivery device including first and second electrodes for attaching the device to an animal body surface and for providing a therapeutic agent through the animal body surface, said control circuit comprising:

a DC supply node for receiving a DC power input;

an inductor having first and second contacts, the first inductor contact being coupled to said DC supply node;

a diode having an anode coupled to the second inductor contact and a cathode coupled to said first electrode;

a switch having a control input, said switch being positioned between the anode and a circuit ground;

a filter capacitor coupled between the cathode and the circuit ground;

a sense resistor coupled between said second electrode and the circuit ground; and

a switch controller having a control output coupled to the control input of said switch and a sensor input coupled to a node between said second electrode and said sense resistor,

wherein said switch controller toggles said switch to induce a working voltage at said first electrode, the induced working voltage driving an electrotransport current through the animal body surface and through said sense resistor, and

wherein said switch controller compares a voltage arising at the sensor input with a reference voltage and boosts the working voltage to a value sufficient to make the voltage arising at the sensor input substantially equal to the reference voltage.

2. A control circuit according to claim 1, wherein said switch controller continually boosts the working voltage to a value sufficient to keep the voltage arising at the feedback input substantially equal to the reference voltage, and wherein the electrotransport current through the animal body surface is maintained at a predetermined level independent of changes in a resistance of the animal body surface.

3. A control circuit according to claim 2, wherein a value of said sense resistor is varied to make the electrotransport drive current follow a predetermined current-time profile.

4. A control circuit according to claim 1, further comprising a second sense resistor coupled between said switch and the circuit ground, wherein said switch controller limits a peak current through said inductor, said switch and said second sense resistor.

5. A method of driving an electrotransport current through an animal body surface, comprising the steps of:

applying a working voltage across a series combination of the animal body surface and a sense resistor to drive the electrotransport current through the animal body surface and through the sense resistor;

comparing a voltage arising across the sense resistor to a reference voltage; and

boosting the working voltage to a level sufficient to make the voltage arising across the sense resistor substantially equal to the reference voltage.

6. A method according to claim 5, wherein the working voltage is continually boosted to a level sufficient to keep the voltage arising across the sense resistor substantially equal to the reference voltage, and wherein the electrotransport current through the animal body surface is maintained at a predetermined level independent of changes in a resistance of the animal body surface.

7. A method according to claim 6, further comprising the step of varying a value of the sense resistor to make the electrotransport drive current follow a predetermined current-time profile.

8. A method according to claim 5, wherein said step of adjusting the working voltage includes the step of toggling a switch in a DC--DC step-up converter including an energy storage inductor, a rectifier diode and a filter capacitor.

9. A method according to claim 8, further comprising the step of limiting a peak current through the energy storage inductor.