Filling containers with particulate material

• US 6,035,905 A
• Filed: 08/14/1998
• Issued: 03/14/2000
• Est. Priority Date: 11/17/1995
• Status: Expired due to Fees

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Griffin, David Peter
• Primary Examiner(s): Douglas, Steven O.
• Assistant Examiner(s): MAUST, TIMOTHY LEWIS
• Application Number:
  US09/068,645
• Time in Patent Office: 578 Days
• Field of Search: 141/2, 141/4, 141/5, 141/8, 141/67, 141/100-103, 141/181-182, 141/184, 141/185, 141/236-238, 141/244, 141/250, 141/286, 141/297, 141/325-327, 53/471, 53/478, 53/539
• US Class Current: 141/181
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: B65B 1/36 by volumetric devices or methods checking volume of filled material B65B1/48
• CPC Class Codes: B65B 11/50 Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins apparatus or devices for forming pockets in or from sheets, blanks or webs B65B47/00
• CPC Class Codes: G01F 11/282 for fluent solid material not provided for in G01F11/34, G01F11/40, G01F11/46

Abstract

A multi-compartment container is charged with a plurality of doses of powdered medicament so that the volume of each dose is than that of the respective compartments in which it is contained. A respective protuberance is inserted into each respective compartment, which is then filled with medicament and the protuberance is then removed. The container may take the form of an apertured plate, in which case the filling step can be achieved by placing the container on a porous bed and in communication with a reservoir of particulate material, and then passing gas through the reservoir, the apertures in the container and the bed. There is also shown apparatus for performing the method, the apparatus comprising a reservoir for the particulate material and a conduit for relaying particulate material from the reservoir to the compartments, the conduit including protuberances which are insertable into the compartments to reduce the available volume of the latter. The size of the doses can be controlled by appropriate selection of protuberance dimensions, and a plate-type container, when filled by the method, can be relatively easily sealed by, for example, the application of laminated foil.

Claims

1. A method of introducing each of a plurality of doses of particulate material into a respective compartment of a container, the container comprising a plate having a plurality of apertures, each of which constitutes a respective compartment, the method comprising the steps of:

a) inserting a respective protuberance into each compartment so as to reduce the capacity thereof;

b) filling each compartment with said particulate material, with the respective protuberance inserted in said compartment by positioning the plate on a porous bed with the apertures in communication with a reservoir of particulate material;

applying gaseous pressure to the reservoir so as to transfer particulate material from the reservoir to the apertures, the porosity of the bed being such as to allow the passage of gas but to prevent the particulate material from passing all the way through the apertures and escaping from the underside of the plate; and

c) removing said protuberances,

wherein the volume of each dose of material is less than that of its respective compartment.

2. A method according to claim 1, in which each protuberance comprises a conduit which is inserted part-way into the respective compartment and through which said particulate material is introduced into said compartment.

3. A method according to claim 2, in which the distance by which each conduit can be inserted into its respective compartment is determined by stop means which engage with the portions of the container around the entrance to the compartment to prevent further insertion.

4. A method according to claim 1, in which the application of gaseous pressure involves passing a gas through the reservoir, the apertures and the porous bed.

5. A method according to claim 4, in which the bed comprises a perforated base plate and a sheet of finely porous material, for example filter paper, interposed, in use, between the base plate and the container.

6. A method according to claim 5, in which the apertures, once filled, are sealed so that each dose is individually encapsulated in its respective aperture.

7. A method according to claim 6, in which said sealing is achieved by bonding a respective sheet of material to each face of the plate.

8. A method according to claim 7, in which the container is sealed by bonding a sheet of material to the uppermost face of the plate while the plate is supported on a support for preventing material escaping from the apertures, inverting the plate, and the support, removing the support to expose the opposite face of the plate, which is then the uppermost face and bonding a sheet of material to said opposite face.

9. A method according to claim 8, in which the support comprises the porous bed.

10. A method according to claim 8, in which the sheet material which seals the apertures comprises a laminated foil which is attached to the body by being heat sealed thereto.

11. A method according to claim 10, in which the plate is flexible, and the method includes the steps of rolling or otherwise forming the plate into a cylinder once it has been filled.

12. A method according to claim 11, in which the container is retained in its cylindrical configuration by applying an annular end cap thereto.

13. A method according to claim 11, in which the plate comprises an array of elongated flat, substantially rigid strips, adjacent pairs of which are hingeable relative to each other, such that the strips are substantially parallel to the axis of the cylinder in the finished container.

14. A method according to claims 1, in which the particulate material comprises a powdered medicament.