Blood pressure estimating apparatus and method

• US 6,036,651 A
• Filed: 05/29/1998
• Issued: 03/14/2000
• Est. Priority Date: 05/12/1998
• Status: Expired due to Fees

• Current Assignee: Omron Healthcare Company Limited (Omron Corporation)
• Original Assignee: Colin Corporation (Fukuda Denshi Company Limited)
• Inventors: Kawaguchi, Keizoh, Inukai, Hidekatsu, Yokozeki, Akihiro
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): ASTORINO, MICHAEL C
• Application Number:
  US09/086,747
• Time in Patent Office: 655 Days
• Field of Search: 600/481-491, 600/300-301, 600/500-508, 128/897-899, 128/920-925
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02255 the pressure being controlled by plethysmographic signals, e.g. derived from optical sensors
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

An apparatus for estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, including: a first device for obtaining first information which relates to velocity of propagation of a pulse wave; a second device for obtaining at least one of second information which relates to heart rate and third information which relates to an area defined by a volume pulse wave; a third device for estimating, according to a predetermined relationship to between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the blood pressure, based on the first information and the at least one of the second information and the third information, the predetermined relationship being defined by a numerical expression including a plurality of predetermined coefficients; and a fourth device for selecting, from a plurality of groups of predetermined coefficients which correspond to a plurality of blood-pressure ranges, respectively, one group of predetermined coefficients which corresponds to a blood pressure, so that the third device estimates the blood pressure according to the numerical expression including the selected group of predetermined coefficients.

Claims

1. An apparatus for successively estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, comprising:

first means for non-invasively obtaining, from the circulatory organ of the subject, first information which relates to velocity of propagation of a pulse wave which propagates through an artery of the subject;

second means for non-invasively obtaining, from the circulatory organ of the subject, at least one of second information which relates to heart rate of the subject and third information which relates to an area defined by a volume pulse wave from a peripheral portion of the subject;

third means for estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the intraarterial blood pressure of the subject, based on the first information obtained by the first means and said at least one of the second information and the third information obtained by the second means, the predetermined relationship being defined by a numerical expression including a plurality of predetermined coefficients; and

fourth means for selecting, from a plurality of groups of predetermined coefficients which correspond to a plurality of blood-pressure ranges, respectively, one group of predetermined coefficients which corresponds to a blood pressure of the subject, so that the third means estimates the intraarterial blood pressure of the subject according to the numerical expression including the selected group of predetermined coefficients.

2. An apparatus according to claim 1, wherein the second means comprises means for obtaining the second information and the third information, and wherein the third means comprises means for estimating, according to the predetermined relationship between (A) blood pressure, and (B1) first information, (B21) second information, and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information, the obtained second information, and the obtained third information.

3. An apparatus according to claim 1, wherein the first means comprises means for obtaining, as the first information, a time, DT, needed for the pulse wave to propagate between two different portions of the artery, wherein the second means comprises means for obtaining, as the second information, a heart-beat period, RR, of the subject, and means for obtaining, as the third information, a ratio, VR, of the area of the volume pulse wave to the heart-beat period RR, and wherein the third means comprises means for estimating, according to the predetermined relationship between (A) blood pressure, EBP, and (B1) time DT, (B21) period RR, and (B22) ratio VR, defined by the following numerical expression:

EBP=α

(1/DT)+β

RR+γ

VR+δ

, where α

, β

, and γ

are the selected group of predetermined coefficients and δ

is a predetermined constant, the intraarterial blood pressure of the subject, based on the obtained time DT, the obtained period RR, and the obtained ratio VR.

4. An apparatus according to claim 3, further comprising a memory which stores a plurality of sets of data indicative of said plurality of groups of predetermined coefficients and a plurality of constants, respectively, each of said groups of predetermined coefficients and a corresponding one of said constants being predetermined by applying a multiple regression analysis to a plurality of sets of information obtained from at least one living person, each of said sets of information comprising a blood pressure obtained from the person, and a time DT, a period RR, and a ratio RR obtained from said person when the blood pressure is obtained from said person.

5. An apparatus according to claim 1, wherein the fourth means comprises means for selecting said one group of predetermined coefficients which corresponds to an intraarterial blood pressure of the subject estimated by the third means, so that the third means estimates a subsequent intraarterial blood pressure of the subject according to the numerical expression including the selected group of coefficients.

6. An apparatus according to claim 1, further comprising a blood-pressure measuring device which includes a pressing band adapted to be wound around a portion of the subject and which measures an actual blood pressure of the subject by changing a pressing pressure of the pressing band, wherein the fourth means comprises means for selecting said one group of predetermined coefficients which corresponds to the actual blood pressure of the subject measured by the measuring device, so that the third means estimates a subsequent intraarterial blood pressure of the subject according to the numerical expression including the selected group of coefficients.

7. An apparatus according to claim 1, wherein the second means comprises means for obtaining the third information selected from the group consisting of the area defined by the volume pulse wave, a ratio of the area to a heart-beat period of the subject, a ratio of the area to a product of the heart-beat period and an amplitude of the volume pulse wave, and a ratio of a product of the area and the amplitude to the heart-beat period.

8. An apparatus according to claim 1, wherein the first means comprises:

a first pulse-wave sensor and a second pulse-wave sensor which non-invasively detect the pulse wave from two different portions of the artery of the subject, respectively; and

means for determining, as the first information, a time needed for the pulse wave to propagate between the two different portions.

9. An apparatus according to claim 8, wherein the second means comprises means for determining, as the second information, a time difference between respective predetermined points of successive two heartbeat-synchronous pulses of the pulse wave detected by one of the first and second pulse-wave sensors.

10. An apparatus according to claim 8, wherein the second means comprises one of the first and second pulse-wave sensors, said one pulse-wave sensor detecting the volume pulse wave from the peripheral portion of the subject.

11. An apparatus according to claim 8, wherein the first and second pulse-wave sensors comprise an electrocardiograph and a photoelectric oximeter.

12. An apparatus according to claim 1, wherein the numerical expression includes at least two coefficients and a single constant, and wherein the apparatus further comprises constant determining means for determining the constant of the numerical expression, by subtracting, from the blood pressure used by the fourth means for selecting said one group of predetermined coefficients, a sum of (a) a first product of a first one of said at least two coefficients and a first parameter indicative of the first information and (b) at least one of (b1) a second product of a second one of said at least two coefficients and a second parameter indicative of the second information and (b2) a third product of a third one of said at least two coefficients and a third parameter indicative of the third information.

13. A method of successively estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, comprising the steps of:

non-invasively obtaining, from the circulatory organ of the subject, first information which relates to velocity of propagation of a pulse wave which propagates through an artery of the subject,

non-invasively obtaining, from the circulatory organ of the subject, at least one of second information which relates to heart rate of the subject and third information which relates to an area defined by a volume pulse wave from a peripheral portion of the subject,

estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information and the obtained at least one of the second information and the third information, the predetermined relationship being defined by a numerical expression including a plurality of predetermined coefficients, and

selecting, from a plurality of groups of predetermined coefficients which correspond to a plurality of blood-pressure ranges, respectively, one group of predetermined coefficients which corresponds to a blood pressure of the subject, so that the intraarterial blood pressure of the subject is estimated according to the numerical expression including the selected group of predetermined coefficients.

14. A method according to claim 13, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining the second information and the third information, and wherein the step of estimating the intraarterial blood pressure of the subject comprises estimating, according to the predetermined relationship between (A) blood pressure, and (B1) first information, (B21) second information, and (B22) third information, the intraarterial blood pressure of the subject, based on the obtained first information, the obtained second information, and the obtained third information.

15. A method according to claim 13, wherein the step of obtaining the first information comprises obtaining a time, DT, needed for the pulse wave to propagate between two different portions of the artery, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining, as the second information, a heart-beat period, RR, of the subject and obtaining, as the third information, a ratio, VR, of the area of the volume pulse wave to the heart-beat period RR, and wherein the step of estimating the intraarterial blood pressure of the subject comprises estimating, according to the predetermined relationship between (A) blood pressure, EBP, and (B1) time DT, (B21) period RR, and (B22) ratio VR, defined by the following numerical expression:

EBP=α

(1/DT)+β

RR+γ

VR+δ

, where α

, β

, and γ

are the selected group of predetermined coefficients and δ

is a predetermined constant, the intraarterial blood pressure of the subject, based on the obtained time DT, the obtained period RR, and the obtained ratio VR.

16. A method according to claim 15, further comprising a step of determining each of said groups of predetermined coefficients and a corresponding one of a plurality of constants, by applying a multiple regression analysis to a plurality of sets of information obtained from at least one living person, each of said sets of information comprising a blood pressure obtained from the person, and a time DT, a period RR, and a ratio VR obtained from said person when the blood pressure is obtained from said person.

17. A method according to claim 13, wherein the step of selecting said one group of predetermined coefficients comprises selecting said one group of predetermined coefficients which corresponds to an estimated intraarterial blood pressure of the subject, so that a subsequent intraarterial blood pressure of the subject is estimated according to the numerical expression including the selected group of coefficients.

18. A method according to claim 13, further comprising a step of measuring an actual blood pressure of the subject by changing a pressing pressure of a pressing band wound around a portion of the subject, wherein the step of selecting said one group of predetermined coefficients comprises selecting said one group of predetermined coefficients which corresponds to the measured actual blood pressure of the subject, so that a subsequent intraarterial blood pressure of the subject is estimated according to the numerical expression including the selected group of coefficients.

19. A method according to claim 13, wherein the step of obtaining said at least one of the second information and the third information comprises obtaining the third information selected from the group consisting of the area defined by the volume pulse wave, a ratio of the area to a heart-beat period of the subject, a ratio of the area to a product of the heart-beat period and an amplitude of the volume pulse wave, and a ratio of a product of the area and the amplitude to the heart-beat period.