Adsorbent for serum amyloid protein

• US 6,037,458 A
• Filed: 09/22/1992
• Issued: 03/14/2000
• Est. Priority Date: 11/20/1987
• Status: Expired due to Fees

• Current Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Original Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Inventors: Tani, Nobutaka, Hirai, Fumiyasu
• Primary Examiner(s): Wax, Robert A.
• Application Number:
  US07/948,470
• Time in Patent Office: 2,730 Days
• Field of Search: 530/380, 530/417, 530/416, 530/413, 530/415, 604/5
• US Class Current: 530/415
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 15/00 Separating processes involving the treatment of liquids with solid sorbents using liquid sorbents B01D11/00; ion exchange processes or materials, sorbent materials in general B01J, e.g. sorbents for chromatography B01J20/281; for investigating or analysing materials G01N30/00; Apparatus therefor
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/321 consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3212 consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3219 involving a particular spacer or linking group, e.g. for attaching an active group
• CPC Class Codes: B01J 20/3248 the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
• CPC Class Codes: B01J 20/3251 comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
• CPC Class Codes: B01J 20/3253 comprising a cyclic structure not containing any of the heteroatoms nitrogen, oxygen or sulfur, e.g. aromatic structures
• CPC Class Codes: B01J 20/3274 Proteins, nucleic acids, polysaccharides, antibodies or antigens
• CPC Class Codes: B01J 20/328 Polymers on the carrier being further modified

Abstract

An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR¹ R², wherein R¹ is hydrogen atom, methyl group or ethyl group, and R² is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R² H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

Claims

1. A method for removing serum amyloid protein from body fluid in a human mammal suffering from amyloidosis and in need of such treatment, comprising the sequential steps of:

a) passing said mammal'"'"'s body fluid containing serum amyloid protein through a container having a fluid inlet and a fluid outlet and being packed with an adsorbent for a serum amyloid protein comprising a water-insoluble carrier and dextran sulfate being immobilized onto said carrier; and

b) returning substantially serum amyloid protein free body fluid to said human mammal.

2. The method of claim 1, wherein said serum amyloid protein is serum amyloid A protein.

3. The method of claim 1, wherein said serum amyloid protein is serum amyloid P protein.

4. The method of claim 1, wherein said water-insoluble carrier is made of a compound containing a hydroxy group.

5. The method of claim 1, wherein said water-insoluble carrier is a hydrophilic carrier.

6. The method of claim 1, wherein said water-insoluble carrier has a porous structure.