Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media

• US 6,037,579 A
• Filed: 03/16/1998
• Issued: 03/14/2000
• Est. Priority Date: 11/13/1997
• Status: Expired due to Fees

• Current Assignee: Biophotonics Information Laboratories Ltd.
• Original Assignee: Biophotonics Information Laboratories Ltd.
• Inventors: Satori, Koji, Chan, Kinpui
• Primary Examiner(s): LE, QUE TAN
• Application Number:
  US09/039,444
• Time in Patent Office: 729 Days
• Field of Search: 250/216, 250/575, 250/576, 250/559.4, 250/559.39, 356/351, 356/345, 356/349, 356/356, 356/244, 356/354, 356/355
• US Class Current: 250/216
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

There is disclosed an optical measurement device which is based on optical interference and it uses a light beam which is radiated to and transmitted through or reflected by a sample, especially a light scattering medium to optically measure the sample. The amount of signal lights effective for optical heterodyne detection is increased, while speckle noises are averaged out. On an observation plane of a concerned point arranged are plural detector elements. From signals obtained by the respective detector elements, an optical signal of the concerned point is obtained.

Claims

1. An optical interferometer apparatus having spatially resolved detection capability to detect a spatially distorted wavefront of a light beam collected from a scattering media comprising:

a light source for emitting a light beam;

a beam splitter for splitting the light beam emitted from said light source into a first partial beam which is guided into an object arm of said optical interferometer apparatus and is then incident to a measured object which is disposed at a position along said object arm, and a second partial beam which is guided into a reference arm of said optical interferometer apparatus;

a collecting lens adapted for collecting light emerging from a point either on a surface of or an inside of said measured object to provide a signal light beam;

a recombining beam splitter for superimposing said signal light beam onto said second partial beam to provide a resultant interference light beam;

a photo detector array configuration having a plurality of spatially arranged detector elements to produce a plurality of detector signal outputs which are position sensitive to a wavefront and intensity distribution of said resultant interference light beam; and

a signal processing unit for summing amplitudes of said plural detector signal outputs to produce a single point data having an amplitude that is regarded as being proportional to an intensity of said signal light beam collected from said point either on the surface of or the inside of said measured object.

2. The optical apparatus according to claim 1, wherein said object arm and said reference arm are parts of a Mach-Zehnder interferometer.

3. The optical apparatus according to claim 1, wherein said light source comprises a continuous wave laser.

4. The optical apparatus according to claim 1, wherein said light source comprises a continuous wave laser having a frequency that is periodically modulated.

5. The optical apparatus according to claim 1, wherein said light source comprises a light source having a short coherence length chosen from a group comprising a light emitting diode, a super luminescent diode, a femtosecond pulsed laser, and a gas discharge lamp.

6. The optical apparatus according to claim 1, wherein said light source comprises a pulsed laser.

7. The optical apparatus according to claim 1, further comprising a frequency difference imparting device for generating a frequency difference between the first partial light beam and the second partial light beam of said apparatus.

8. The optical apparatus according to claim 7, wherein said frequency difference imparting device comprises at least one or more acousto-optic modulators.

9. The optical apparatus according to claim 8, wherein said frequency difference imparting device comprises at least one or more electro-optic phase modulators.

10. The optical apparatus according to claim 8, wherein said frequency difference imparting device comprises a piezoelectric element.

11. The optical apparatus according the claim 1, further comprising a scanning mechanism which one-dimensionally or two-dimensionally moves at least one of the measured object and the first partial light beam in said object arm to scan said measured object with said first partial light beam.

12. The optical apparatus according to claim 1, further comprising a rotation mechanism that rotates at least one of the measured object and the first partial light beam in said object arm.

13. The optical apparatus according to claim 1, further comprising a pair of lenses disposed in the object arm for transmitting said signal light beam collected by said collecting lens to said recombining beam splitter, and an aperture disposed on a Fourier plane of the pair of lenses for spatial filtering.

14. The optical apparatus according to claim 1, wherein said signal processing unit rectifies and sums up said plurality of detector signal outputs from said photo detector array.

15. The optical apparatus according to claim 1, wherein said signal processing unit performs phase matching for said plural detector signal outputs from said photo detector array, and sums up their amplitudes.