Device for determining the levels of NO in exhaled air

• US 6,038,913 A
• Filed: 03/20/1998
• Issued: 03/21/2000
• Est. Priority Date: 03/27/1997
• Status: Expired due to Term

• Current Assignee: Circassia AB
• Original Assignee: Aerocrine AB (Circassia Group Plc)
• Inventors: Stromberg, Stefan Per Axel, Gustafsson, Lars Erik, Persson, Gunnar Magnus Severus
• Primary Examiner(s): Larkin, Daniel S.
• Assistant Examiner(s): Politzer, Jay L.
• Application Number:
  US09/045,374
• Time in Patent Office: 732 Days
• Field of Search: 73/23.3, 73/23.21, 600/531, 600/532, 600/343
• US Class Current: 73/23.3
• CPC Class Codes: A61B 5/0813 Measurement of pulmonary parameters by tracers, e.g. radioactive tracers

Abstract

A device for determining the level of nitric oxide in an exhaled airstream belonging to a living organism selected to have its lung function evaluated, where an initial device is arranged to determine the current portion of nitric oxide and/or the distribution of nitric oxide over time during an exhalation phase. During the commencing period of the exhalation phase, the exhaled air is arranged to pass with no or with only a very small resistance or back-pressure to a free space, and during the remaining period, the exhaled air is arranged to pass through the initial device against the action of a suitable resistance or back-pressure. The level of nitric oxide is measured during this remaining period.

Claims

1. Device for determining the level of nitric oxide generated within the body of a living organism in an exhaled airstream belonging to the living organism selected to have its lung function evaluated, said device including a measuring device arranged to determine a current portion of said generated nitric oxide and/or a distribution of said generated nitric oxide over time during an exhalation phase, a first fluid path which allows a first portion of exhaled air from the organism during a commencing period of the exhalation phase to pass with no or with only a very small resistance or back-pressure to a free space, and a second fluid path which allows a second portion of the exhaled air from the organism during a remaining duration of the exhalation phase to pass through said measuring device against a resistance or back-pressure so that the level of said generated nitric oxide in the second portion of the exhaled air can be measured.

2. Device according to claim 1 characterised by a volume of exhaled air during the commencing period of exhalation being chosen to exceed the volume of the dead space of the organism.

3. Device according to claim 1 characterised by a volume of exhaled air during the commencing period of exhalation being chosen to be less than 20 times that of the dead space.

4. Device according to claim 3 characterized by a volume of exhaled air during the commencing phase of exhalation being chosen to be 1 to 10 times that of the dead space.

5. Device according to claim 3 characterized by a volume of exhaled air during the commencing phase of exhalation being chosen to be 4 to 8 times that of the dead space.

6. Device according to claims 1, 2 or 3 characterised by said measuring device including measuring means for measuring the level of nitric oxide only during said remaining duration of the exhalation phase of a deep or normal breathing cycle.

7. Device according to claim 5 characterized by the back-pressure being chosen to be in the range of 3 to 15 cm of water.

8. Device according to claim 6 characterised by a number of measurements during the remaining duration of several exhalation phases being processed to give mean values.

9. Device according to claim 1 characterised by the back-pressure being chosen to be in the range of 1 to 25 of water.

10. Device according to claim 1 further including a valve that can be controlled to switch between a first phase and a second phase and that is adapted for directing exhaled air along one of the two paths.

11. Device according to claim 10 characterised by the valve being arranged to partly close-off a channel intended for exhaled air.

12. Device according to claim 11 characterised by the volume of the first phase being limited by an air-tight container connected to the exhalation channel.

13. Device according to claim 12 characterised by the container being capable of collecting gas and having its final volume adapted to be 1-10 times the volume expected of a dead space of a person.

14. Device according to claim 13 characterised by the remaining duration of the exhalation phase taking place against a suitable back-pressure once the container is filled.

15. Device according to claim 1 characterised by a shift between the commencing period and the remaining duration of the exhalation phase being controlled by a level of carbon dioxide in the exhaled air.

16. Device according to claim 1 characterised by shift between the commencing period and the remaining duration of the exhalation phase being controlled by a flow meter.

17. Device according to claim 9 characterised by a suitable back-pressure being selected only during the remaining duration of the exhalation phase.

18. Device according to claim 1 characterised by that the back-pressure during at least a portion of the remaining duration of the exhalation phase is selected to be identical on every occasion when comparable values are to be measured.

19. Device according to claim 13 further including a fluid restricting channel extending from an end of said gas collecting container and characterised by that the remaining duration of the exhalation phase occurs by the exhaled air passing through a suitable hole in said fluid restricting channel from the gas collecting container while the nitric oxide measurement takes place in an inlet to the gas collecting container.