Position triggered dispenser and methods

• US 6,039,211 A
• Filed: 09/22/1998
• Issued: 03/21/2000
• Est. Priority Date: 09/22/1998
• Status: Expired due to Fees

• Current Assignee: Glaxo Wellcome Incorporated (GlaxoSmithKline PLC)
• Original Assignee: Glaxo Wellcome Incorporated (GlaxoSmithKline PLC)
• Inventors: Slater, Joseph A., Chan, Sam
• Primary Examiner(s): Douglas, Steven O.
• Assistant Examiner(s): HUYNH, KHOA D
• Application Number:
  US09/158,326
• Time in Patent Office: 546 Days
• Field of Search: 141/1, 141/94, 141/156, 141/157, 141/159, 141/160, 141/130, 141/129, 141/178, 141/237, 141/238, 141/242, 141/244, 422/65, 422/100, 422/101, 422/102, 73/863.1, 73/863.32, 222/1, 222/137, 222/402.24
• US Class Current: 222/1
• CPC Class Codes: B65B 57/06 and operating to control, or to stop, the feed of articles or material to be packaged
• CPC Class Codes: G01N 2035/0493 Locating samples; identifying different tube sizes
• CPC Class Codes: G01N 2035/0494 Detecting or compensating piositioning errors
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/1065 Multiple transfer devices

Abstract

The invention provides systems, methods, and apparatus for dispensing liquids. According to one method, a plate is provided having a plurality of wells. At least one marker is also provided and is associated with at least some of the wells. The plate and marker are moved relative to a plurality of liquid dispensing elements, and the presence of the marker is sensed with a sensor that is disposed at a known location relative to the dispensing elements. The sensing of the marker indicates that at least some of the wells are aligned with the dispensing elements. As such, liquid is dispensed from the dispensing elements and into the aligned wells after sensing the presence of the marker.

Claims

1. A method for dispensing a liquid, comprising:

providing a plate having a plurality of wells;

providing at least one marker that is spaced apart from the wells;

moving the plate and the marker relative to a plurality of liquid dispensing elements;

sensing the presence of the marker with a non-contact sensor that is disposed at a known location relative to the dispensing elements, wherein sensing of the marker indicates that at least some of the wells are aligned with the dispensing elements; and

dispensing liquid from the dispensing elements and into the aligned wells upon sensing the presence of the marker.

2. A method as in claim 1, wherein the marker is disposed on a carrier, and further comprising positioning the plate on the carrier and translating the carrier to move the plate.

3. A method as in claim 1, wherein the wells are disposed in rows, wherein a separate marker is associated with each row, and further comprising moving the plate and the markers until a second one of the markers is sensed and dispensing liquid from the dispensing elements into a second row of the wells.

4. A method as in claim 3, wherein each marker is aligned with one of the rows of wells.

5. A method as in claim 1, further comprising dispensing the same liquid from each dispensing element.

6. A method as in claim 1, further comprising dispensing a different liquid from each dispensing element.

7. A method as in claim 1, further comprising controlling the volume of liquid dispensed into the aligned wells.

8. A method as in claim 1, wherein the liquid is under pressure, and further comprising opening a valve positioned between the pressurized liquid and the dispensing elements after sensing the presence of the marker to dispense the liquid from the dispensing elements.

9. A method as in claim 1, wherein the marker comprises a transparent region in the plate, and further comprising sensing with the sensor the transmission of light through the transparent region.

10. A method as in claim 1, wherein the marker comprises an opaque region in the plate, and further comprising sensing with the sensor the blockage of light caused by the marker.

11. A method as in claim 1, further comprising sensing a change in reflected light to sense the presence of the marker.

12. A method as in claim 1, wherein the sensor is vertically aligned with the dispensing elements.

13. A liquid dispensing apparatus, comprising:

at least one source of liquid;

a plurality of liquid dispensing elements coupled to the source of liquid;

a non-contact sensor disposed at a known location relative to the dispensing elements, wherein the sensor is adapted to sense the presence of a marker that is spaced apart from a plurality of wells of a plate; and

a controller to dispense liquid from the dispensing elements upon receipt of a signal from the sensor indicating that the marker has been sensed and that at least some of the wells are aligned with the dispensing elements.

14. An apparatus as in claim 13, wherein the source of liquid is under pressure, and further comprising at least one valve coupled to the source of liquid, wherein the controller is configured to open the valve upon receipt of the signal from the sensor to allow the liquid to be dispensed through the dispensing elements.

15. An apparatus as in claim 14, wherein the controller comprises a relay which sends a signal to open the valve upon receipt of the signal from the sensor.

16. An apparatus as in claim 13, further comprising a manifold to which the dispensing elements are coupled.

17. An apparatus as in claim 13, further comprising a carrier having the marker, wherein the carrier is adapted to removably hold the plate.

18. An apparatus as in claim 17, further comprising a base having at least one track along which the carrier is translatable.

19. An apparatus as in claim 13, further comprising a plurality of liquid sources, wherein each dispensing element is coupled to a separate source of liquid.

20. An apparatus as in claim 13, wherein the sensor is vertically aligned with the dispensing elements.

21. A liquid dispensing system, comprising:

a plate having a plurality of wells;

a carrier having at least one marker and a region for removably holding the plate such that the marker is spaced apart from the wells;

at least one source of liquid;

a plurality of liquid dispensing elements coupled to the source of liquid;

a non-contact sensor that is disposed to sense the presence of the marker when at least some of the wells are aligned with the dispensing elements; and

a controller to dispense liquid from the dispensing elements upon receipt of a signal from the sensor indicating that the marker has been sensed and that at least some of the wells are aligned with the dispensing elements.

22. A system as in claim 21, further comprising a base having at least one track along which the carrier is translatable.

23. A system as in claim 21, wherein the marker comprises a darkened region on the carrier, and wherein the sensor is configured to sense a change in reflectance of light as the sensor passes over the marker.

24. A system as in claim 21, wherein the wells are disposed in rows and a separate marker for each row is included on the carrier.

25. A system as in claim 21, wherein the source of liquid is under pressure, and further comprising at least one valve coupled to the source of liquid, wherein the controller is configured to open the valve upon receipt of the signal from the sensor to allow the liquid to be dispensed through the dispensing elements.

26. A system as in claim 25, wherein the controller comprises a relay which sends a signal to open the valve upon receipt of the signal from the sensor.

27. A system as in claim 21, further comprising a manifold to which the dispensing elements are coupled.

28. A system as in claim 21, further comprising a plurality of liquid sources, wherein each dispensing element is coupled to a separate source of liquid.

29. A multi-well plate, comprising:

a plate body having a plurality of wells that are arranged in rows; and

a plurality of markers positioned on the plate body at locations spaced apart from the wells, with each marker corresponding to a separate row of wells, wherein the markers are adapted to be detected by a sensor to indicate the position of the wells relative to dispensing elements that are used to introduce a liquid into the wells.

30. A plate as in claim 29, wherein each marker comprises a transparent region in the plate that is surrounded by an opaque area.

31. A plate as in claim 29, wherein each marker comprises an opaque region in the plate that is surrounded by a transparent area.

32. A method for dispensing a liquid, comprising:

providing a plate having a plurality of wells;

providing at least one marker that is associated with at least some of the wells;

moving the plate and the marker relative to a plurality of liquid dispensing elements;

sensing the presence of the marker with a sensor that is disposed at a known location relative to the dispensing elements, wherein sensing of the marker indicates that at least some of the wells are aligned with the dispensing elements; and

dispensing liquid from the dispensing elements and into the aligned wells after sensing the presence of the marker;

wherein the marker comprises a transparent region in the plate, and further comprising sensing with the sensor the transmission of light through the transparent region.

33. A method for dispensing a liquid, comprising:

providing a plate having a plurality of wells;

providing at least one marker that is associated with at least some of the wells;

moving the plate and the marker relative to a plurality of liquid dispensing elements;

sensing the presence of the marker with a sensor that is disposed at a known location relative to the dispensing elements, wherein sensing of the marker indicates that at least some of the wells are aligned with the dispensing elements; and

dispensing liquid from the dispensing elements and into the aligned wells after sensing the presence of the marker;

wherein the marker comprises an opaque region in the plate, and further comprising sensing with the sensor the blockage of light caused by the marker.

34. A liquid dispensing system, comprising:

a plate having a plurality of wells;

a carrier having at least one marker and a region for removably holding the plate;

at least one source of liquid;

a plurality of liquid dispensing elements coupled to the source of liquid;

a sensor that is disposed to sense the presence of the marker when at least some of the wells are aligned with the dispensing elements; and

a controller to dispense liquid from the dispensing elements upon receipt of a signal from the sensor indicating that the marker has been sensed and that at least some of the wells are aligned with the dispensing elements;

wherein the marker comprises a darkened region on the carrier, and wherein the sensor is configured to sense a change in reflectance of light as the sensor passes over the marker.

35. A multi-well plate, comprising:

a plate body having a plurality of wells; and

at least one marker selectively positioned on the plate body, wherein the marker is adapted to be detected by a sensor to indicate the position of the wells relative to dispensing elements that are used to introduce a liquid into the wells;

wherein the marker comprises a transparent region in the plate that is surrounded by an opaque area.

36. A multi-well plate, comprising:

a plate body having a plurality of wells; and

at least one marker selectively positioned on the plate body, wherein the marker is adapted to be detected by a sensor to indicate the position of the wells relative to dispensing elements that are used to introduce a liquid into the wells;

wherein the marker comprises an opaque region in the plate that is surrounded by a transparent area.