Device and method for preparing a treatment liquid by filtration

• US 6,039,877 A
• Filed: 09/22/1997
• Issued: 03/21/2000
• Est. Priority Date: 07/26/1994
• Status: Expired due to Term

• Current Assignee: Industries Gambro
• Original Assignee: Hospal Industrie
• Inventors: Chevallet, Jacques, Riquier, Jean-Claude
• Primary Examiner(s): FORTUNA, ANA M
• Application Number:
  US08/934,903
• Time in Patent Office: 911 Days
• Field of Search: 210/636, 210/195.2, 210/791, 210/90, 210/111, 210/97, 210/134
• US Class Current: 210/636
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1672 using membrane filters, e.g. for sterilising the dialysate
• CPC Class Codes: A61M 1/3465 using dialysate as substitution fluid
• CPC Class Codes: A61M 2205/707 Testing of filters for clogging
• CPC Class Codes: A61M 2205/7554 with means for unclogging or regenerating filters
• CPC Class Codes: A61M 2205/7563 with means preventing clogging of filters

Abstract

A device for treatment of blood by extracorporeal circulation comprises a dialysis liquid circuit having a supply tube (9a, 9b) on which is arranged a filter (21) having a first chamber and a second chamber (22, 23) which are separated by a filtering membrane (24), the supply tube having a first portion (9a) connecting a dialysis liquid source (10) to an inlet of the first chamber (22), and a second portion (9b) having an end connected to an outlet of the second chamber (23) of the filter (21) and another end which can be connected to an inlet of a compartment (3) of an exchanger (1) with semipermeable membrane (4). A feedback tube (25) connects the inlet of the first chamber (22) of the filter (21) to the outlet of the first chamber (22). A flushing pump (26) is arranged on the feedback tube (25) for circulating liquid in the first chamber (22) of the filter (21) and causing cleaning of the membrane (24) by tangential flushing.

Claims

1. A method for cleaning a filter having a first chamber and a second chamber separated by a filtering membrane, the first chamber having an outlet and having an inlet connected to a treatment liquid source, and the second chamber having an outlet for the filtered treatment liquid, the method comprising the steps of:

conveying treatment liquid from the source through the first chamber;

recirculating during a recirculation mode, all treatment liquid from the outlet of the first chamber to the inlet of the first chamber so that all treatment liquid exiting the first chamber is fed-back through a feedback line into the first chamber;

adding to the recirculating treatment liquid additional treatment liquid from the source;

measuring a clogging level of the filter;

comparing the measured clogging level with a predetermined clogging threshold;

intermittently purging during a purge mode, the first chamber when the measured clogging level reaches the predetermined clogging threshold;

measuring a frequency of purges of the first chamber;

comparing the measured purge frequency with a purge frequency reference value; and

increasing flow speed of treatment liquid through the first compartment when the measured purge frequency exceeds the purge frequency reference value.

2. The method of claim 1, further including the step of intermittently purging the feedback line during the step of intermittently purging the first chamber.

3. The method according to claim 1, wherein the step of measuring a clogging level of the filter comprises the substeps of:

measuring a transmembrane pressure of the filter; and

comparing the measured transmembrane pressure with a reference transmembrane pressure.

4. The method according to claim 3, wherein the reference transmembrane pressure is measured each time the filter is set in operation.

5. The method according to claim 1, wherein during the step of recirculating a substantially constant pressure is maintained in the second chamber of the filter.

6. The method according to claim 1, wherein the step of measuring a clogging level of the filter comprises the substeps of:

measuring the speed of rotation of a pump used for recirculating the treatment liquid through the first chamber of the filter;

comparing the measured speed of rotation with a reference speed of rotation.

7. The method according to claim 6, wherein the reference speed of rotation is a speed measured each time the filter is set in operation.

8. A method for cleaning a filter having a first chamber and a second chamber separated by filtering membrane, the first chamber having an outlet and having an inlet connected to a treatment liquid source, and the second chamber having an outlet for the filtered treatment liquid, the method comprising the steps of:

conveying treatment liquid from the source through the first chamber;

monitoring treatment liquid flow upstream of the filter using a first flow monitoring element;

monitoring treatment liquid flow downstream of a permeate filter using a second flow monitoring element;

recirculating during a recirculation mode, all treatment liquid form the outlet of the first chamber to the inlet of the first chamber so that all treatment liquid exiting the first chamber is fed-back into the first chamber;

adding to the recirculating treatment liquid additional treatment liquid from the source;

measuring a clogging level of the filter;

comparing the measured clogging level with a predetermined clogging threshold;

intermittently purging during a purge mode, the first chamber when the measured clogging level reaches the predetermined clogging threshold; and

calibrating the first and second flow monitoring elements during the ste of purging by bypassing the filter, and flow connecting the first flow monitoring element to the second flow monitoring element.