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7-phenyl-1, 4-diazepane compounds, process for their preparation, and pharmaceutical compositions containing them

  • US 6,040,303 A
  • Filed: 08/27/1998
  • Issued: 03/21/2000
  • Est. Priority Date: 08/27/1997
  • Status: Expired due to Term
First Claim
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1. A compound corresponding to the formula I:

  • ##STR47## wherein R1 is hydrogen or lower alkyl,R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR2 and R3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, andR5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, orR4 and R5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring,R6 is lower alkyl, halogen or trifluoromethyl,R7 is lower alkyl, halogen or trifluoromethyl,A is a --(CH2)n -- group in which n represents an integer from 1 to 3, or an --NH--(CH2)m -- group in which m represents an integer from 2 to 3, andB is an alkylene chain with 1 to 3 carbon atoms, optionally substituted by lower alkyl,or a pharmaceutically acceptable acid addition salt thereof.

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