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Nucleic acid encoding site specific recombinase and nuclear receptor fusion protein

  • US 6,040,430 A
  • Filed: 12/26/1995
  • Issued: 03/21/2000
  • Est. Priority Date: 06/28/1993
  • Status: Expired due to Term
First Claim
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1. A fusion protein, comprising (1) a site specific recombinase protein and (2) the ligand binding domain of a nuclear receptor which is attached at the C- or N-terminus of said site specific recombinase protein, such that, in a cell or cell-free system containing DNA target sites which are specifically recognized by said site specific recombinase protein:

  • (a) site specific recombinase activity of said fusion protein in relation to the DNA target sites is inhibited in the absence of ligand binding to said ligand binding domain, and(b) inhibition of said site specific recombinase activity of said fusion protein in relation to the DNA target sites is relieved by binding of ligand to said ligand binding domain.

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