Method and apparatus for multi-spectral analysis of organic blood analytes in noninvasive infrared spectroscopy

• US 6,040,578 A
• Filed: 02/02/1996
• Issued: 03/21/2000
• Est. Priority Date: 02/02/1996
• Status: Expired due to Term

• Current Assignee: GLT Acquisition Corporation
• Original Assignee: Instrumentation Metrics Inc.
• Inventors: Malin, Stephen F., Khalil, Gamal
• Primary Examiner(s): Hannaher, Constantine
• Application Number:
  US08/597,480
• Time in Patent Office: 1,509 Days
• Field of Search: 250/343, 250/339.1, 250/339.11, 250/339.12, 128/633, 128/664, 600/473
• US Class Current: 250/339.12
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A method and apparatus are described for determining the concentration of an organic blood analyte using multi-spectral analysis in the near infrared and mid-infrared ranges. Incident radiation containing a plurality of distinct, nonoverlapping regions of wavelengths in the range of approximately 1100 to 5000 nm is used to scan a sample. Diffusively reflected radiation emerging from the sample is detected, and a value indicative of the concentration of the analyte is obtained using an application of chemometrics techniques. Information obtained from each nonoverlapping region of wavelengths can be cross-correlated in order to remove background interferences.

Claims

1. An apparatus for determining the concentration of an organic blood analyte in a body tissue sample, comprising:

(a) means for irradiating the sample with incident radiation containing a plurality of distinct, nonoverlapping spectral regions within the infrared spectrum, wherein each of the spectral regions encompass a range of wavelengths between approximately 1100 and 5000 nanometers;

(b) means for collecting reflected radiation emerging from tie sample and directing said reflected radiation into a beam path;

(c) adjustable filter means disposed in the beam path, wherein said adjustable filter means attenuates the intensity of radiation in the beam path;

(d) principal analyte filter means capable of receiving radiation emerging from the adjustable filter means, and selectively passing discrete wavelengths therefrom, wherein said discrete wavelengths are specifically correlated with the concentration of the analyte;

(e) second filter means capable of receiving the discrete wavelengths emerging from the principal analyte filter means and attenuating the intensity of said wavelengths;

(f) detection means for receiving the attenuated wavelengths emerging from the second filter means;

(g) means for converting the detected wavelengths into a signal representative of the intensity of said wavelengths; and

(h) means for correlating the signal obtained in step (g) to determine the concentration of the analyte.

2. The apparatus of claim 1, wherein the adjustable filter means comprises a neutral density filter.

3. The apparatus of claim 1, wherein the second filter means comprises a neutral density filter.

4. The apparatus of claim 1, wherein the detection means comprises a lead selenide (PbSe) detector.

5. An apparatus for determining the concentration of an organic blood analyte in a body tissue sample, comprising:

(a) means for irradiating the sample with incident radiation containing a plurality of distinct, nonoverlapping spectral regions within the infrared spectrum, wherein each of the spectral regions encompass a range of wavelengths between approximately 1100 and 5000 nanometers;

(b) means for collecting reflected radiation emerging from the sample and directing said reflected radiation into a beam path;

(c) filter means disposed in the beam path, said filter means comprising a plurality of sections each configured to selectively pass at least one different wavelength from the reflected radiation emerging from the sample;

(d) a plurality of detectors arranged such that each wavelength emerging from the filter means is detected by a discrete detector;

(e) means for converting the detected wavelengths into a signal representative of the intensity of said wavelengths; and

(f) means for correlating the signal obtained in step (e) to determine the concentration of the analyte.

6. The apparatus of claim 5, wherein the filter means comprises a two-stage filter having a first stage comprising a plurality of sections each configured to selectively pass at least one different wavelength from the reflected radiation emerging from the sample a second stage arranged adjacent to the first stage and capable of attenuating the intensity of each selectively passed wavelength emerging from the first stage of the filter means.

7. The apparatus of claim 6, wherein the second stage of the two-stage filter means is a neutral density filter.

8. The apparatus of claim 5, wherein the filter means comprises a plurality of discrete filter elements.

9. The apparatus of claim 8, wherein at least one discrete filter element comprises an absorption characteristic selected to provide enhanced correlation of a passed wavelength with the concentration of the analyte.

10. The apparatus of claim 5, wherein the plurality of detectors comprise lead selenide (PbSe) detectors.

11. The apparatus of claim 5, wherein the filter means comprises a first section configured to pass at least one wavelength from a first spectral region of wavelengths in the range of approximately 1300 to 1360 nm, a second section configured to pass at least one wavelength from a second spectral region of wavelengths in the range of approximately 1670 to 1690 nm, a third section configured to pass at least one wavelength from a third spectral region of wavelengths in the range of approximately 1930 to 1950 mn, and a fourth section configured to pass at least one wavelength from a fourth spectral region of wavelengths in the range of approximately 2120 to 2280 nm.

12. An apparatus for determining the concentration of an organic blood analyte in a body tissue sample, comprising:

(a) means for irradiating the sample with incident radiation containing a plurality of distinct, nonoverlapping spectral regions within the infrared spectrum, wherein each of the spectral regions encompass a range of wavelengths between approximately 1100 and 5000 nanometers;

(b) means for collecting reflected radiation emerging from the sample and directing said reflected radiation into a beam path;

(c) diffraction grating means disposed in the beam path for receiving reflected radiation emerging from the sample and selectively passing discrete wavelengths therefrom, wherein said discrete wavelengths are specifically correlated with the concentration of the analyte;

(d) a linear detector array for receiving the passed wavelengths emerging from the diffraction grating means;

(e) means for converting the detected wavelengths into a signal representative of the intensity of said wavelengths; and

(f) means for correlating the signal obtained in step (e) to determine the concentration of the analyte.

13. The apparatus of claim 12, wherein the linear detector array comprises a lead selenide (PbSe) linear detector array.