Method and apparatus for frequency encoded ultrasound-modulated optical tomography of dense turbid media

• US 6,041,248 A
• Filed: 10/22/1997
• Issued: 03/21/2000
• Est. Priority Date: 05/07/1997
• Status: Expired due to Fees

• Current Assignee: Texas A&M University System
• Original Assignee: Texas A&M University System
• Inventors: Wang, Lihong
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US08/955,671
• Time in Patent Office: 881 Days
• Field of Search: 73/957, 73/597, 367/7, 356/340, 600/437, 600/443, 600/438
• US Class Current: 600/407
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 29/2418 using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046
• CPC Class Codes: G01N 29/348 with frequency characteristics, e.g. single frequency signals, chirp signals measuring frequency of mechanical vibrations or acoustic waves in general G01H1/06, G01H3/04; measuring frequency or analysing frequency spectra G01R23/00

Abstract

An apparatus (10) for frequency encoded ultrasound modulated optical tomography is provided. A function generator (12) produces a frequency sweep signal which is applied to an ultrasonic transducer (20). The ultrasonic transducer (20) produces ultrasonic wave (25) in a turbid medium (21). Coherent light from a laser (22) is passed through turbid medium (21) where it is modulated by the ultrasonic wave (25). A photomultiplier tube (24) detects the light which passes through the turbid medium (21). The signal from the photomultiplier tube (24) is fed to an oscilloscope (30) and then to a computer (32) where differences in light intensity at different frequencies can determine the location of objects in the turbid medium (21).

Claims

1. An apparatus for frequency encoded ultrasound modulated optical tomography comprising:

a function generator operable to produce a frequency sweep signal;

an ultrasonic transducer coupled to the function generator and operable to produce an ultrasonic wave in a turbid medium in response to the frequency sweep signal;

a laser, located outside the turbid medium and operable to send a coherent beam of light into the turbid medium;

a photo multiplier tube located outside the turbid medium and operable to detect light from the laser that has traveled through the turbid medium and that has been modulated by the ultrasonic wave; and

an oscilloscope operable to display the output of the photo multiplier tube wherein differences in the oscilloscope display is indicative of an abnormality in the turbid medium.

2. The apparatus of claim 1, further comprising a pulse generator operable to trigger the operation of the function generator.

3. The apparatus of claim 1, further comprising a transformer operable to amplify the frequency sweep signal and to send the frequency sweep signal to the oscilloscope as a modulation signal.

4. The apparatus of claim 1, further comprising a computer coupled to the oscilloscope and operable to receive data from the oscilloscope and to process the data to enable determination of different structures in the turbid medium.

5. The apparatus of claim 1, wherein the ultrasonic transducer comprises a plurality of individual ultrasonic transducer elements coupled to individual function generators.

6. The apparatus of claim 5, wherein a portion of the plurality of individual ultrasonic transducer elements are operated sequentially.

7. The apparatus of claim 5, further comprising a time delay means coupled to each of the plurality of individual ultrasonic transducer elements and operable to delay the frequency sweep signal from the function generator to the plurality of individual ultrasonic generator.

8. The apparatus of claim 1, further comprising a band pass filter operable to select frequencies of interest.

9. The apparatus of claim 1, wherein the turbid medium is human tissue.

10. The apparatus of claim 1, wherein the abnormality is a neoplasm.

11. A method for imaging an object located in a turbid medium comprising the steps of:

producing a frequency sweep signal;

producing an ultrasonic wave in the turbid medium in response to the frequency sweep signal;

sending a coherent beam of light into the turbid medium;

receiving a portion of the coherent beam of light that has been modulated by the ultrasonic wave and that has passed through the turbid medium, the coherent beam of light modulated by the ultrasound wave indicating a location of an object in the turbid medium;

determining the location of the object located in the turbid medium from the coherent beam of light.

12. The method of claim 11, wherein the turbid medium is human tissue.

13. The method of claim 11, wherein the object located in the turbid medium is a neoplasm.

14. The method of claim 11, wherein the step of producing an ultrasonic wave further comprises the step of sequential operating a portion of an array of ultrasound generators.

15. The method of claim 11, wherein the step of producing an ultrasonic wave further comprises the step of using a time delay circuit to operate a phased array of ultrasound generators.

16. The method of claim 11, wherein the step of producing a frequency sweep signal further comprises the step of triggering the function generator with a pulse generator.

17. The method of claim 11, further comprising the step of mixing a modulated signal from the function generator with the portion of the coherent light that traveled through the turbid medium.

18. The method of claim 11, further comprising the step of selecting frequencies of interest with a band pass filter.

19. An apparatus for the detection of objects located in a turbid medium comprising:

a function generator operable to produce a frequency sweep signal;

an ultrasonic transducer coupled to the function generator and a turbid medium and operable to produce an ultrasonic wave in the turbid medium in response to the frequency sweep signal;

a light source, located outside the turbid medium and operable to send a coherent beam of light into the turbid medium;

a light detection device located outside the turbid medium and operable to detect light from the light source that has traveled through the turbid medium and that has been modulated by the ultrasonic wave; and

a computer operable to translate the signal from the light detection device and determine the location of an object in the turbid medium.

20. The apparatus of claim 19, further comprising a pulse generator operable to trigger the operation of the function generator.

21. The apparatus of claim 19, further comprising a transformer operable to amplify the frequency sweep signal and to send the frequency sweep signal to the light detection device as a modulation signal.

22. The apparatus of claim 19, wherein the ultrasonic transducer comprises a plurality of individual ultrasonic transducer elements coupled to individual function generators.

23. The apparatus of claim 22, wherein a portion of the plurality of individual ultrasonic transducer elements are operated sequentially.

24. The apparatus of claim 22, further comprising a time delay means coupled to each of the plurality of individual ultrasonic transducer elements and operable to delay the frequency sweep signal from the function generator to the plurality of individual ultrasonic transducer elements.

25. The apparatus of claim 19, further comprising a band pass filter operable to select frequencies of interest.

26. The apparatus of claim 19, wherein the turbid medium is human tissue.

27. The apparatus of claim 19, wherein the object is a neoplasm.

28. The apparatus of claim 19, wherein the light source is a laser.