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Test device and method for quantitative measurement of an analyte in a liquid

  • US 6,042,543 A
  • Filed: 10/14/1997
  • Issued: 03/28/2000
  • Est. Priority Date: 03/11/1997
  • Status: Expired due to Term
First Claim
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1. A device of substantially flat construction for application to the skin of a patient, collection of a test sample of sweat, and quantitative determination of the chloride concentration in the test sample of sweat, comprising:

  • a top transparent liquid-impermeable layer;

    a bottom liquid-impermeable layer for contacting the skin comprising a centrally located inlet and a plurality of channels extending radially from the inlet for collecting the sweat and directing the sweat toward the inlet; and

    a middle layer between the top and bottom layers comprising an absorbent material having substantially uniformly dispersed throughout at least a portion thereof (i) a liquid-detecting agent capable of detectably delimiting the liquid front formed as the liquid portion of the test sample migrates radially outwardly from the inlet through the substantially flat absorbent material, and (ii) a partitioning agent comprising a species capable of complexing with chloride ions present in the test sample to form a detectable precipitate disposed radially inwardly of said liquid front.

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