Guidewire having hydrophilic coating

• US 6,042,876 A
• Filed: 11/23/1998
• Issued: 03/28/2000
• Est. Priority Date: 06/21/1996
• Status: Expired due to Fees

• Current Assignee: Medtronic Ave Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Deem, Mark E.
• Primary Examiner(s): DUDASH, DIANA L
• Application Number:
  US09/198,190
• Time in Patent Office: 491 Days
• Field of Search: 427/358, 427/2.28, 427/2.1, 427/117, 427/118, 427/120, 427/178, 427/434.7, 427/434.4, 427/434.6
• US Class Current: 427/2.28
• CPC Class Codes: A61M 2025/09091 where a sheath surrounds the coil at the distal part
• CPC Class Codes: A61M 2025/09175 having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 Guide wires

Abstract

A guidewire comprises a core wire having a coil tip at its distal end. The coil tip includes a helically wound filament having adjacent turns spaced apart by a preselected distance. The guidewire is coated with a polymeric material, typically a hydrophilic polysaccharide, such as hyaluronic acid or chondroitin sulfate. By properly selecting the spacing between adjacent turns of the coil tip, the hydrophilic coating will adhere to the coil tip in a manner which does not penetrate the coil and which does not significantly interfere with flexibility and bendability of the coil tip.

Claims

1. A method for coating a guidewire, said method comprising:

providing a guidewire having a proximal end and a distal coil comprising a wound filament having a plurality of successive spaced apart turns;

providing a reservoir having an aperture in a bottom surface thereof;

introducing a coating solution into the reservoir;

passing the guidewire upwardly through aperture so that a layer of the coating solution adheres to the outer surface of the guidewire; and

curing the coating solution to form a hydrophilic coating on the outer surface of the guidewire.

2. A method as in claim 1, wherein the distal coil of the guidewire comprises a wound filament having a plurality of successive, spaced-apart turns, wherein the coating step comprises passing the coil through the aperture at a rate which results in bridging of the coating solution between the successive turns and inhibiting penetration of the coating solution to the interior of the coil.

3. A method as in claim 2, wherein the proximal end of the guidewire is passed through the aperture first.

4. A method as in claim 1, wherein the coating solution comprises a hydrophilic polymer.

5. A method as in claim 4, wherein the hydrophilic polymer is a polysaccharide selected from the group consisting of hyaluronic acid and chondroitin sulfate.

6. A method as in claim 5, wherein the solution is applied at room temperature where it has a viscosity in the range from 20 cp to 300 cp.

7. A method as in claim 6, wherein the guidewire is passed upwardly at a rate in the range from 0.1 cm/sec to 30 cm/sec.

8. A method as in claim 1, wherein the coating solution is applied to a thickness in the range from 0.025 μ

m to 0.5 mm.

9. A method as in claim 1, wherein the curing step comprises heating to a temperature in the range from 40°

C. to 200°

C. for a period of time from 15 minutes to 24 hours.

10. A method for coating a guidewire, said method comprising:

providing a guidewire having a proximal end and a distal coil;

providing a reservoir having an aperture in a bottom surface thereof;

introducing a coating solution into the reservoir, said coating solution selected from the group consisting of a polyvinylpyrrolidone or a polysaccharide;

passing the guidewire upwardly through aperture so that a layer of the coating solution adheres to the outer surface of the guidewire; and

curing the coating solution to form a hydrophilic coating on the outer surface of the guidewire.

11. A method as in claim 10, wherein the distal coil of the guidewire comprises a wound filament having a plurality of successive, spaced-apart turns, wherein the coating step comprises passing the coil through the aperture at a rate which results in bridging of the coating solution between the successive turns and inhibiting penetration of the coating solution to the interior of the coil.

12. A method as in claim 11, wherein the proximal end of the guidewire is passed through the aperture first.

13. A method as in claim 10, wherein the hydrophilic polymer is a polysaccharide selected from the group consisting of hyaluronic acid and chondroitin sulfate.

14. A method as in claim 13, wherein the solution is applied at room temperature where it has a viscosity in the range from 20 cp to 300 cp.

15. A method as in claim 14, wherein the guidewire is passed upwardly at a rate in the range of 0.1 cm/sec to 30 cm/sec.

16. A method as in claim 10, wherein the coating solution is applied to a thickness in the range from 0.025 μ

m to 0.5 mm.

17. A method as in claim 10, wherein the curing step comprises heating to a temperature in the range from 40°

C. to 200°

C. for a period of time from 15 minutes to 24 hours.