Nucleotide analogues

• US 6,043,060 A
• Filed: 05/18/1999
• Issued: 03/28/2000
• Est. Priority Date: 11/18/1996
• Status: Expired due to Fees

• Current Assignee: Takeshi Imanishi
• Original Assignee: Takeshi Imanishi
• Inventors: Imanishi, Takeshi
• Primary Examiner(s): Elliott, George C.
• Assistant Examiner(s): Epps, Janet L.
• Application Number:
  US09/308,367
• Time in Patent Office: 315 Days
• Field of Search: 536/23.1, 536/27.1, 536/25.6, 536/26.1, 424/1.73
• US Class Current: 435/91.1
• CPC Class Codes: C07H 19/10 with the saccharide radical esterified by phosphoric or polyphosphoric acids
• CPC Class Codes: C07H 19/20 with the saccharide radical esterified by phosphoric or polyphosphoric acids
• CPC Class Codes: C07H 21/00 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• CPC Class Codes: C12N 15/113 Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing when used in plants C12N15/8218
• CPC Class Codes: C12N 2310/3231 having an additional ring, e.g. LNA, ENA

Abstract

An oligonucleotide analog or an antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized, is provided. It is an oligo- or polynucleotide analog containing one or more monomer units being nucleotide analogs of the general formula: ##STR1## where B may be identical or different, and is a pyrimidine or purine nucleic acid base, or a derivative thereof.

Claims

1. An oligo- or polynucleotide analog containing one or more monomer units of the general formula:

##STR6## where B may be identical or different, and is a pyrimidine or purine nucleic acid base, or a derivative thereof.

2. The oligo- or polynucleotide analog of claim 1, comprising a total of 2 to 50 nucleotide units.

3. A nucleoside analog of the general formula:

##STR7## where B is a pyrimidine or purine nucleic acid base, or a derivative thereof, and Y₁ and Y₂ are identical or different, and is a hydrogen atom or a protective group for a hydroxyl group.