Apparatus and method for measuring an induced perturbation to determine a physiological parameter

• US 6,045,509 A
• Filed: 02/19/1998
• Issued: 04/04/2000
• Est. Priority Date: 04/15/1994
• Status: Expired due to Term

• Current Assignee: Vital Insite, Inc.
• Original Assignee: Vital Insite, Inc.
• Inventors: Caro, Richard G., Sher, Mark H., Flaherty, Bryan P.
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/026,048
• Time in Patent Office: 775 Days
• Field of Search: 600/481, 600/485, 600/490, 600/493-6, 600/500, 600/503
• US Class Current: 600/481
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Abstract

A monitor for determining a patient'"'"'s physiological parameter includes a calibration device configured to provide a calibration signal representative of the patient'"'"'s physiological parameter. An exciter is positioned over a blood vessel of the patient for inducing a transmitted exciter waveform into the patient. A noninvasive sensor is positioned over the blood vessel, where the noninvasive sensor is configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of the hemoparameter containing a component of a physiological parameter waveform and a component of a received exciter waveform. In this context, a hemoparameter is defined as any physiological parameter related to vessel blood such as pressure, flow, volume, velocity, blood vessel wall motion, blood vessel wall position and other related parameters. A processor is configured to determine a relationship between a property of the received exciter waveform and a property of the physiological parameter. The processor is connected to receive the calibration signal and the noninvasive sensor signal, and the processor is configured to process the calibration signal and the noninvasive sensor signal to determine the physiological parameter. In the preferred embodiment, the physiological parameter measured is blood pressure, however, the present invention can also be used to analyze and track other physiological parameters such as vascular wall compliance, strength of ventricular contractions, vascular resistance, fluid volume, cardiac output, myocardial contractility and other related parameters.

Claims

1. A monitor for determining a physiological parameter of a patient, comprising:

a calibration device configured to provide a calibration signal representative of one of the patient'"'"'s physiological parameters;

an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient;

a noninvasive sensor adapted to be positioned over said blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal containing a component of a received exciter waveform that varies with a period of the blood pressure;

a processor coupled to said noninvasive sensor and including a filter configured to separate said received excited waveform that varies with a period of the blood pressure from at least one other component of the noninvasive sensor signal that does not so vary;

wherein said processor is configured to determine a relationship between a property of said received exciter waveform and a property of said physiological parameter based at least in part on said calibration signal; and

wherein said processor is connected to receive said calibration signal and said noninvasive sensor signal and is configured to determine said physiological parameter based at least in part on said noninvasive sensor signal and said relationship.

2. The monitor of claim 1, wherein:

said processor is configured to determine said relationship by comparing a property of said received exciter waveform to one of the set of diastolic, mean and systolic blood pressure provided by said calibration device as said calibration signal.

3. The monitor of claim 1, wherein:

said processor is configured to determine said relationship by comparing one of the set of phase, amplitude, velocity and pseudo-velocity of said received exciter waveform to one of the set of diastolic, mean and systolic blood pressure provided by said calibration device as said calibration signal.

4. The monitor of claim 1, wherein:

said processor is configured to store historical relationships between a property of said received exciter waveform and a property of said physiological parameter as data and configured use said data to determine said relationship between a property of said received exciter waveform and a property of said physiological parameter.

5. The monitor of claim 1, wherein:

said processor is configured to determine said relationship based at least in part on an event repeated at intervals of less than 3 minutes over an extended period of time with minimal adverse effect on the patient.

6. The monitor of claim 1, wherein:

said processor is configured to determine said relationship based at least in part on an event in which the duration of arterial occlusion is insufficient for ischemia induced discomfort to occur.

7. A processor for determining a physiological parameter of a patient with an apparatus having a calibration device configured to provide a calibration signal representative of one of the patient'"'"'s physiological parameters, an exciter adapted to be positioned over a blood vessel of the patient and configured to induce a transmitted exciter waveform into the patient, and a noninvasive sensor adapted to be positioned over said blood vessel and configured to sense a hemoparameter and to generate a noninvasive sensor signal representative of said hemoparameter, said processor comprising:

a first input configured to receive said calibration signal;

a second input configured to receive said noninvasive sensor signal;

a filter configured to separate from said noninvasive sensor signal a component representing a received exciter waveform that varies with a period of the blood pressure from at least one other component of the noninvasive sensor signal that does not so vary;

a relationship routine configured to determine a relationship between a property of said received exciter waveform and a property of said physiological parameter based at least in part on said calibration signal; and

a determination routine configured to determine said physiological parameter based at least in part on said noninvasive sensor signal and said relationship.

8. The processor of claim 7, wherein:

said determination routine is configured to determine said relationship by comparing a property of said received exciter waveform to one of the set of diastolic, mean and systolic blood pressure provided by said calibration device.

9. The processor of one of claims 7 and 8, wherein:

said processor is configured to store historical relationships between a property of said received exciter waveform and a property of said physiological parameter as data; and

said determination routine is configured to use said data to determine said relationship between a property of said received exciter waveform and a property of said physiological parameter.

10. The processor of one of claims 7 and 8, wherein:

said processor is configured to initiate a calibration procedure to provide a calibration signal when said determination routine determines that said relationship has changed.

11. The processor of claim 8, wherein said calibration device includes an inflatable pressure cuff adapted to be positioned on the same limb as said noninvasive sensor, and further comprising:

a control routine configured to control said inflatable cuff to an inflation pressure; and

wherein said determination routine is configured to determine said relationship between a property of said exciter waveform and a property of said physiological parameter based at least in part on said inflation pressure.

12. A method of determining a physiological parameter of a patient, comprising the steps of:

providing a calibration signal representative of one of the patient'"'"'s physiological parameters and storing the calibration signal;

inducing a transmitted exciter waveform into the patient;

noninvasively sensing a hemoparameter and generating a noninvasive sensor signal representative of said hemoparameter and containing a component of a received exciter waveform that varies with a period of the blood pressure;

separating from said noninvasive sensor signal a component representing a received exciter waveform that varies with a period of the blood pressure from at least one other component of the noninvasive sensor signal that does not so vary;

determining a relationship between a property of said received exciter waveform and a property of said physiological parameter based at least in part on said calibration signal; and

processing said calibration signal and said noninvasive sensor signal to determine said physiological parameter based at least in part on said noninvasive sensor signal and said relationship.

13. The method of claim 12, wherein:

said determining step is performed by determining said relationship by comparing a property of said received exciter waveform to one of the set of diastolic, mean and systolic blood pressure provided by said calibration device as said calibration signal.

14. The method of claim 12, wherein:

said determining step is performed by determining said relationship by comparing one of the set of phase, amplitude, velocity and pseudo-velocity of said received exciter waveform to one of the set of diastolic, mean and systolic blood pressure provided by said calibration device as said calibration signal.

15. The method of claim 12, wherein:

said determining step includes the steps of storing historical relationships between a property of said received exciter waveform and a property of said physiological parameter as data and using said data to determine said relationship between a property of said received exciter waveform and a property of said physiological parameter.

16. The method of claim 12, wherein:

said determining step includes the step of determining said relationship based at least in part on an event repeated at intervals of less than 3 minutes over an extended period of time with minimal adverse effect on the patient.

17. The method of claim 12, wherein:

said determining step is based at least in part on an event in which the duration of arterial occlusion is insufficient for ischemia induced discomfort to occur.