Inner ear fluid transfer and diagnostic system

• US 6,045,528 A
• Filed: 06/13/1997
• Issued: 04/04/2000
• Est. Priority Date: 06/13/1997
• Status: Expired due to Term

• Current Assignee: DURECT Corporation
• Original Assignee: IntraEAR, Inc. (DURECT Corporation)
• Inventors: Arenberg, Michael H., Arenberg, Irving K.
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): Sadula, Jennifer R.
• Application Number:
  US08/874,208
• Time in Patent Office: 1,026 Days
• Field of Search: 604/27, 604/43, 604/48, 604/93, 604/269, 604/174, 604/271, 604/280, 604/28, 604/49, 604/54, 128/DIG. 26
• US Class Current: 604/28
• CPC Class Codes: A61B 2017/00787 Surgery of the ear
• CPC Class Codes: A61F 11/202 Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
• CPC Class Codes: A61M 1/85 with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants for negative pressure wound therapy A61M1/92, A61M1/94; combined with tracheal tubes A61M16/0463; dental instruments with combined rinsing and aspirating A61C17/0208
• CPC Class Codes: A61M 2210/0668 Middle ear

Abstract

An apparatus for transferring fluids into and out of the inner ear through the round window membrane. The apparatus includes a cover member sized for placement over the round window niche. Fluid delivery and fluid extraction conduits are provided which are operatively connected to the cover member so that fluids can pass therethrough. The cover member is positioned over the niche to create a fluid-recieving zone between the cover member and the round window membrane. As a result, fluids can be delivered into or withdrawn from the zone. Alternatively, a single conduit may be used for fluid delivery and extraction. Another variation uses a compressible cover member positioned within the round window niche to form a fluid-receiving zone between the cover member and the round window membrane. The same type of conduit system described above is attached to the compressible cover member.

Claims

1. A method for moving fluid materials through the round window niche and round window membrane of a living subject in order to treat the inner ear thereof, said round window niche comprising an internal cavity therein and a main opening leading into said internal cavity, said method comprising:

providing a medical treatment apparatus comprising;

a cover member sized for placement over said main opening of said round window niche of said subject so that said cover member seals said round window niche in order to form a sealed fluid-receiving zone within said round window niche between said cover member and said round window membrane;

a fluid delivery conduit comprising a first end, a second end, and an internal passageway extending continuously through said fluid delivery conduit from said first end to said second end, said fluid delivery conduit being operatively connected to said cover member so that said fluid delivery conduit can deliver at least one therapeutic fluid composition through said cover member to said fluid-receiving zone during use of said treatment apparatus; and

a fluid extraction conduit comprising a first end, a second end, and an internal passageway extending continuously through said fluid extraction conduit from said first end of said fluid extraction conduit to said second end of said fluid extraction conduit, said fluid extraction conduit being operatively connected to said cover member so that said fluid extraction conduit can remove residual fluid materials from said fluid-receiving zone during use of said treatment apparatus;

inserting said cover member of said treatment apparatus into said middle ear;

positioning said cover member over said main opening of said round window niche in order to seal said main opening so that said sealed fluid-receiving zone is created within said round window niche between said cover member and said round window membrane;

delivering said therapeutic fluid composition into and through said internal passageway of said fluid delivery conduit so that said therapeutic fluid composition passes through said cover member, enters said fluid-receiving zone, and comes in contact with said round window membrane, said therapeutic fluid composition thereafter passing through said round window membrane and into said inner ear for treatment thereof; and

withdrawing any of said residual fluid materials which are present within said fluid-receiving zone through said internal passageway of said fluid extraction conduit so that said residual fluid materials can be removed from said subject.

2. The method of claim 1 wherein said withdrawing of said residual fluid materials from said fluid-receiving zone comprises applying suction to said second end of said fluid extraction conduit.

3. The method of claim 1 further comprising:

providing electrical potential transmission means secured to at least one of said fluid delivery conduit and said fluid extraction conduit for transmitting electrical potentials into and out of said inner ear through said round window membrane, said electrical potential transmission means comprising an elongate conductive member affixed to at least one of said fluid delivery conduit and said fluid extraction conduit; and

placing at least a portion of said elongate conductive member in direct contact with said round window membrane.

4. The method of claim 3 further comprising analyzing said electrical potentials received from said inner ear and transmitted through said elongate conductive member.

5. A method for moving fluid materials through the round window niche and round window membrane of a living subject in order to treat the inner ear thereof, said method comprising:

providing a cover member sized to seal said round window niche;

sealing said round window niche with said cover member in order to form a sealed fluid-receiving zone within said round window niche between said cover member and said round window membrane; and

delivering a supply of at least one therapeutic fluid composition through said cover member and into said fluid-receiving zone between said cover member and said round window membrane, said therapeutic fluid composition thereafter coming in contact with said round window membrane, passing through said round window membrane, and entering said inner ear for treatment thereof.

6. A method for moving fluid materials through the round window niche and round window membrane of a living subject in order to treat the inner ear thereof, said round window niche comprising an internal cavity therein and a main opening leading into said internal cavity, said method comprising:

providing a medical treatment apparatus comprising;

a cover member sized for placement over said main opening of said round window niche so that said cover member seals said round window niche in order to form a sealed fluid-receiving zone within said round window niche between said cover member and said round window membrane; and

a fluid transfer conduit comprising a first end, a second end, and an internal passageway extending continuously through said fluid transfer conduit from said first end to said second end, said fluid transfer conduit being operatively connected to said cover member so that said fluid transfer conduit can deliver at least one therapeutic fluid composition through said cover member to said fluid-receiving zone during use of said apparatus;

inserting said cover member of said treatment apparatus into said middle ear;

positioning said cover member over said main opening of said round window niche in order to seal said main opening so that said fluid-receiving zone is created within said round window niche between said cover member and said round window membrane; and

delivering said therapeutic fluid composition into and through said internal passageway of said fluid transfer conduit so that said therapeutic fluid composition passes through said cover member, enters said fluid-receiving zone, and comes in contact with said round window membrane, said therapeutic fluid composition thereafter passing through said round window membrane and into said inner ear for treatment thereof.

7. The method of claim 6 further comprising withdrawing any residual fluid materials which are present within said fluid-receiving zone through said internal passageway of said fluid transfer conduit so that said residual fluid materials can be removed from said subject.

8. The method of claim 6 further comprising:

providing electrical potential transmission means secured to said fluid transfer conduit for transmitting electrical potentials into and out of said inner ear through said round window membrane, said electrical potential transmission means comprising an elongate conductive member affixed to said fluid transfer conduit; and

placing at least a portion of said elongate conductive member in direct contact with said round window membrane.

9. A method for moving fluid materials through the round window niche and round window membrane of a living subject in order to treat the inner ear thereof, said round window niche comprising an internal cavity therein and a main opening leading into said internal cavity, said method comprising:

providing a medical treatment apparatus comprising;

a cover member sized for placement over said main opening of said round window niche so that said cover member seals said round window niche in order to form a sealed fluid-receiving zone within said round window niche between said cover member and said round window membrane; and

at least one conduit comprising an internal passageway extending continuously through said conduit, said conduit being operatively connected to said cover member; and

positioning said cover member of said medical treatment apparatus over said main opening of said round window niche in order to seal said main opening so that said fluid-receiving zone is created within said round window niche between said cover member and said round window membrane.

10. A method for moving fluid materials through the round window niche and round window membrane within the middle ear of a living subject in order to treat the inner ear thereof, said method comprising:

providing a cover member;

inserting said cover member into said middle ear;

positioning said cover member within said middle ear so that said cover member creates a fluid-receiving zone within said round window niche between said cover member and said round window membrane; and

delivering a supply of at least one therapeutic fluid composition through said cover member and into said fluid-receiving zone so that said therapeutic fluid composition comes in contact with said round window membrane, passes through said round window membrane, and enters said inner ear for treatment thereof.