Nutritional formulations containing oligosaccharides

• US 6,045,854 A
• Filed: 03/31/1997
• Issued: 04/04/2000
• Est. Priority Date: 03/31/1997
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Erney, Renee M., Prieto, Pedro A., Kirchner, Stephen J.
• Primary Examiner(s): HEGGESTAD, HELEN F
• Application Number:
  US08/829,157
• Time in Patent Office: 1,100 Days
• Field of Search: 426/801, 426/658, 426/72, 426/73, 426/74
• US Class Current: 426/658
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1872 Linoleic acid
• CPC Class Codes: A23V 2250/28 Oligosaccharides
• CPC Class Codes: A23V 2250/304 Choline
• CPC Class Codes: A23V 2250/70 Vitamins
• CPC Class Codes: A23V 2250/702 Vitamin A
• CPC Class Codes: A23V 2250/704 Vitamin B
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A23V 2250/71 Vitamin D
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: Y10S 426/801 Pediatric

Abstract

A nutritional formulation containing at least one of the following oligosaccharides: from about 400 to about 3500 mg/L of 3-fucosyllactose; from about 200 to about 2200 mg/L of lacto-N-fucopentaose III; from about 100 to about 1500 mg/L of lacto-N-fucopentaose II; from about 100 to about 2500 mg/L of difucosyllactose; from about 500 to about 4500 mg/L of 2'"'"' fucosyllactose; from about 250 to about 3300 mg/L of lacto-N-fucopentaose I; from about 100 to about 900 mg/L of Lacto-N-neoTetraose; from about 50 to about 2300 mg/L of lacto-N-fucopentaose V; or from about 300 to about 2800 mg/L of lacto-N-tetraose.

Claims

1. A synthetic nutritional composition comprising at least one of the following oligosaccharides:

from about 130 to about 3500 mg/L of 3-fucosyllactose;

from about 120 to about 2200 mg/L of lacto-N-fucopentaose III;

from about 100 to about 1500 mg/L of lacto-N-fucopentaose II;

from about 50 to about 2500 mg/L of difucosyllactose;

from about 350 to about 4500 mg/L of 2'"'"'fucosyllactose;

from about 50 to about 3300 mg/L of lacto-N-fucopentaose I;

from about 100 to about 900 mg/L of lacto-N-neotetraose;

or

from about 15 to about 2300 mg/L of lacto-N-fucopentaose V; and

edible macronutrients wherein said edible macronutrients are formulated for feeding to a human.

2. A synthetic nutritional composition comprising at least one of the following oligosaccharides:

from about 130 to about 3500 mg/L of 3-fucosyllactose;

from about 120 to about 2200 mg/L of lacto-N-fucopentaose III;

from about 100 to about 1500 mg/L of lacto-N-fucopentaose II;

from about 50 to about 2500 mg/L of difucosyllactose;

from about 350 to about 4500 mg/L of 2'"'"'fucosyllactose;

from about 50 to about 3300 mg/L of lacto-N-fucopentaose I;

from about 100 to about 900 mg/L of lacto-N-neotetraose;

or

from about 15 to about 2300 mg/L of lacto-N-fucopentaose V; and

edible macronutrients formulated for feeding to a human wherein said macronutrients comprise at least one of coconut oil, soy oil, mono- and diglycerides, glucose, food grade lactose, electrodialysed whey and electrodialysed skim milk, milk whey, and soy protein.

3. A synthetic nutritional composition comprising at least one of the following oligosaccharides:

from about 130 to about 3500 mg/L of 3-fucosyllactose;

from about 120 to about 2200 mg/L of lacto-N-fucopentaose III;

from about 100 to about 1500 mg/L of lacto-N-fucopentaose II;

from about 50 to about 2500 mg/L of difucosyllactose;

from about 350 to about 4500 mg/L of 2'"'"'fucosyllactose;

from about 50 to about 3300 mg/L of lacto-N-fucopentaose I;

from about 100 to about 900 mg/L of lacto-N-neotetraose;

or

from about 15 to about 2300 mg/L of lacto-N-fucopentaose V;

at least one of vitamins A, C, D, E and B complex and edible macronutrients formulated for feeding to an infant wherein said macronutrients comprise at least one of coconut oil, soy oil, mono- and diglycerides, glucose, food grade lactose, electrodialysed whey and electrodialysed skim milk, milk whey, and soy protein.

4. A composition comprising:

A) at least one of the following oligosaccharides;

from about 130 to about 3500 mg/L of 3-fucosyllactose;

from about 120 to about 2200 mg/L of lacto-N-fucopentaose III;

from about 100 to about 1500 mg/L of lacto-N-fucopentaose II;

from about 50 to about 2500 mg/L of difucosyllactose;

from about 350 to about 4500 mg/L of 2'"'"'fucosyllactose;

from about 50 to about 3300 mg/L of lacto-N-fucopentaose I;

from about 100 to about 900 mg/L lacto-N-neotetraose;

from about 15 to about 2300 mg/L of lacto-N-fucopentaose V; and

B) edible macronutrients formulated for feeding to a human;

one of more of coconut oil, soy oil, mono- and diglycerides, glucose, food grade lactose, electrodialysed whey, electrodialysed skim milk and milk whey;

one or more vitamins selected from the group consisting of A, C, D, E and B complex; and

one or more minerals selected from the group consisting of calcium, magnesium, manganese, sodium, potassium, phosphorus, copper, zinc chloride, iodine, selenium and iron.

5. The composition of claim 4 wherein the oligosaccharides are present in the following amounts:

from about 800 to about 1750 mg/L of 3-fucosyllactose;

from about 400 to about 1100 mg/L of lacto-N-fucopentaose III;

from about 200 to about 750 mg/L of lacto-N-fucopentaose II;

from about 200 to about 1450 mg/L of difucosyllactose;

from about 10000 to about 2400 mg/L of 2'"'"' fucosyllactose;

from about 500 to about 1650 mg/L of lacto-N-fucopentaose I;

from about 200 to about 450 mg/L of Lacto-N-neoTetraose;

or

from about 100 to about 1600 mg/L of lacto-N-fucopentaose V.

6. The composition of claim 5 wherein the oligosaccharides are present in the composition in the following amounts:

from about 1456 to about 1472 mg/L of 3-fucosyllactose;

from about 507 to about 578 mg/L of lacto-N-fucopentaose III;

from about 361 to about 429 mg/L of lacto-N-fucopentaose II;

from about 393 to about 494 mg/L of difucosyllactose;

from about 2240 to about 2260 mg/L of 2'"'"' fucosyllactose;

from about 845 to about 912 mg/L of lacto-N-fucopentaose I;

from about 258 to about 279 mg/L of lacto-N-neotetraose;

or

from about 120 to about 154 mg/L of lacto-N-fucopentaose V.