Method of treatment with medical agents

• US 6,046,225 A
• Filed: 05/04/1995
• Issued: 04/04/2000
• Est. Priority Date: 08/02/1989
• Status: Expired due to Term

• Current Assignee: Glycorex Transplantation AB
• Original Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Inventors: Maddock, Stephen W.
• Primary Examiner(s): TRAVERS, RUSSELL S
• Application Number:
  US08/434,889
• Time in Patent Office: 1,797 Days
• Field of Search: 514/387
• US Class Current: 514/387
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/3486 Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents

Abstract

A method of therapeutic or diagnostic treatment using a medical agent in which there will be beneficial effects if the level of circulating medical agent is reduced artificially faster than the reduction by the normal clearance or routes that obviate normal clearance mechanisms. The method includes the extracorporeal removal of the medical agent by passing bodily fluid from the patient over a support adapted to selectively immobilize the medical agent.

Claims

1. A method for therapeutic or diagnostic treatment of a living being comprising the steps of:

a) administering a medical agent labeled with an affinity ligand to the living being; and

b) removing the medical agent from said living being by passing bodily fluid over a support having immobilized receptor to the affinity ligand.

2. The method of claim 1 wherein said affinity ligand and receptor are selected from the group consisting of an enzyme and a substrate or substrate analog.

3. The method of claim 1 wherein said affinity ligand and receptor are selected from the group consisting of an antibody and an antigen or hapten.

4. The method of claim 1 wherein said affinity ligand and receptor are selected from the group consisting of avidin and biotin.

5. The method of claim 1 wherein said medical agent is selected from the group consisting of drugs, drug/hapten complexes, enzymes, carbohydrates, antibodies, cytokines, biological response modifiers, glycoproteins, lipids/glycolipids, proteolipids, hormones, proteins, large protein complexes, liposomes, carbohydrate complexes, and inorganic complexes.