Use of 4'-bromoflavone in a cancer chemopreventative composition and method

• US 6,046,231 A
• Filed: 03/19/1999
• Issued: 04/04/2000
• Est. Priority Date: 05/15/1998
• Status: Expired due to Fees

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Board of Trustees of The University of Illinois
• Inventors: Moriarty, Robert M., Song, Lynda Li, Moon, Richard C., Pezzuto, John M., Kosmeder, Jerome W. II
• Primary Examiner(s): Goldberg, Jerome D.
• Application Number:
  US09/273,203
• Time in Patent Office: 382 Days
• Field of Search: 514/456
• US Class Current: 514/456
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658

Abstract

A composition and method of cancer chemoprevention is disclosed. The composition and method utilize 4'"'"'-bromoflavone as a cancer chemo-preventative agent in mammals, including humans.

Claims

1. A method of chemopreventing a cancer sensitive to 4'"'"'-bromoflavone, said method comprising administering a sufficient amount of a cancer chemopreventative composition comprising 4'"'"'-bromoflavone to a mammal in need thereof to prevent, delay, or reverse a cancer sensitive to 4'"'"'-bromoflavone.

2. The method of claim 1 wherein the composition is a solid.

3. The method of claim 1 wherein the composition is a liquid.

4. The method of claim 1 wherein the composition is administered topically.

5. The method of claim 1 wherein the composition is administered orally.

6. The method of claim 1 wherein the composition is administered parenterally.

7. The method of claim 1 wherein the composition is administered buccally or sublingually.

8. The method of claim 1 wherein the composition is administered nasally.

9. The method of claim 1 wherein the composition is administered vaginally or rectally.

10. The method of claim 1 wherein the composition is a food additive.

11. The method of claim 1 wherein the composition is a pharmaceutical.

12. The method of claim 1 wherein the composition is administered in an amount of about 0.005 to about 1 micromoles per kg per day.

13. The method of claim 1 wherein the composition is administered in an amount of about 0.05 to about 0.75 micromoles per kg per day.

14. The method of claim 1 wherein the composition is administered in an amount of about 0.075 to about 0.5 micromoles per kg per day.

15. The method of claim 1 wherein the composition is administered prior to exposure of the mammal to a carcinogen or a procarcinogen.

16. The method of claim 1 wherein the composition is administered during or after exposure of the mammal to a carcinogen or a procarcinogen.

17. The method of claim 1 wherein the mammal is a human.

18. The method of claim 1 wherein the cancer chemopreventative composition induces a measurable increase of phase II enzymes in the mammal.