Magnetic resonance apparatus
First Claim
1. A magnetic resonance apparatus comprises:
- first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide;
second applying means for applying, to a second nuclide whose spins are magnetically coupled to the first nuclide, an RF pulse corresponding to a resonance frequency of the second nuclide;
gradient magnetic field applying means for applying a gradient magnetic field;
detecting means for detecting the MR signal from the spins of the first nuclide; and
control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, wherein,in the predetermined pulse sequence,first and second RF pulses are applied to the first nuclide and, simultaneously with or after application of the second RF pulse, a third RF pulse is applied to the second nuclide magnetically coupled to the spins of the first nuclide, whereby there occurs a first polarization transfer from spins of the first nuclide to spins of the second nuclide;
a fourth RF pulse is applied to the spins of the second nuclide after the first polarization transfer;
after the application of the fourth RF pulse, a fifth RF pulse is applied to the first nuclide together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclide in the first area are selectively excited, there occurs a second polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those first MR signals are collected from the spins of the first nuclides in the first area experiencing the first and second polarization transfers; and
after the collection of the first MR signals, a sixth RF pulse is applied to the first nuclide together with at least slice gradient magnetic field pulse, whereby the spins of the first nuclides in a second area are selectively excited, there occurs a third polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those second MR signals are collected from the spins of the first nuclides in the second area experiencing the first and third polarization transfers.
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Accused Products
Abstract
First and second RF pulses are applied to a 1 H and, simultaneously with or after the application of the second RF pulse, a third RF pulse is applied to the 13 C magnetically coupled to the 1 H, whereby there occurs a first polarization transfer from the spin of the 1 H to the spin of the 13 C. After the first polarization transfer, a fourth RF pulse is applied to the 13 C. After the application of the fourth RF pulse, a fifth RF pulse is applied to the 1 H together with a first slice gradient magnetic pulse. By doing so, those 1 H spins in the first area are selectively excited, there occurs a second polarization transfer from the spin of the 13 C to the spin of the 1 H and those first MR signals are collected from those spins of the 1 H in the first area experiencing the first and second polarization transfers. After the collection of a first MR signal, a sixth RF pulse is applied to the 1 H together with a second slice gradient magnetic field pulse, whereby those 1 H in a second area are selectively excited, there occurs a third polarization transfer from the spin of the 13 C to the spin 1 H and those second MR signals are collected from the spins of the 1 H in the second areas experiencing the first and third polarization transfers.
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Citations
33 Claims
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1. A magnetic resonance apparatus comprises:
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first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide; second applying means for applying, to a second nuclide whose spins are magnetically coupled to the first nuclide, an RF pulse corresponding to a resonance frequency of the second nuclide; gradient magnetic field applying means for applying a gradient magnetic field; detecting means for detecting the MR signal from the spins of the first nuclide; and control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, wherein, in the predetermined pulse sequence, first and second RF pulses are applied to the first nuclide and, simultaneously with or after application of the second RF pulse, a third RF pulse is applied to the second nuclide magnetically coupled to the spins of the first nuclide, whereby there occurs a first polarization transfer from spins of the first nuclide to spins of the second nuclide; a fourth RF pulse is applied to the spins of the second nuclide after the first polarization transfer; after the application of the fourth RF pulse, a fifth RF pulse is applied to the first nuclide together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclide in the first area are selectively excited, there occurs a second polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those first MR signals are collected from the spins of the first nuclides in the first area experiencing the first and second polarization transfers; and after the collection of the first MR signals, a sixth RF pulse is applied to the first nuclide together with at least slice gradient magnetic field pulse, whereby the spins of the first nuclides in a second area are selectively excited, there occurs a third polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those second MR signals are collected from the spins of the first nuclides in the second area experiencing the first and third polarization transfers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A magnetic resonance apparatus comprising:
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first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide; second applying means for applying, to a second nuclide magnetically coupled to the spins of the first nuclide, an RF pulse corresponding to a resonance frequency of the second nuclide; gradient magnetic field applying means for applying a gradient magnetic field; detecting means for detecting the MR signal from the spins of the first nuclide; and control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, whereby in the predetermined pulse sequence first and second RF pulses are applied to the first nuclide, a third RF pulse is applied, simultaneously with or after the application of the second RF pulse, to the second nuclide magnetically coupled to the spins of the first nuclide, a refocusing RF pulse to the first nuclide and an inversion RF pulse to the second nuclide are applied at an interval between the first RF pulse and the second RF pulse, whereby there occurs a first polarization transfer from the spins of the first nuclide to the spins of the second nuclide; a fourth RF pulse is applied to the second nuclide after the first polarization transfer; after the application of the fourth RF pulse, a fifth RF pulse to the first nuclide is applied together with at least one of slice gradient magnetic field pulses, whereby the spins of the first nuclide in a first area are selectively excited, there occurs a second polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those first MR signals are collected from those spins of the first nuclides in the first area experiencing the first and second polarization transfers; and after the collection of the first MR signals, a sixth RF pulse to the first nuclide is applied together with at least one of the slice gradient magnetic field pulses, whereby the spins of the first nuclide in a second area are selectively are excited, there occurs a third polarization transfer from the spin of the second nuclide to the spin of the first nuclide and those second MR signals are collected from those first nuclides in a second area experiencing the first and third polarization transfers. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A magnetic resonance apparatus comprising:
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first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide; second applying means for applying, to a second nuclide magnetically coupled to the spins of the first nuclide, an RF pulse corresponding to a resonance frequency of the second nuclide; gradient magnetic field applying means for applying a gradient magnetic field; detecting means for detecting the MR signal from the spins of the first nuclide; and control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, whereby in the predetermined pulse sequence first and second RF pulses are applied to the first nuclide and a third RF pulse is applied, simultaneously with or after the application of the second RF pulse, to the second nuclide magnetically coupled to the spins of the first nuclide, whereby there occurs a first polarization from the spins of the first nuclide to the spins of the second nuclide; after the first polarization transfer, a fourth RF pulse is applied to the second nuclide; the RF pulse to the first nuclide is applied at an interval between the third RF pulse and the fourth RF pulse; after the application of the fourth RF pulse, a fifth RF pulse to the first nuclide is applied together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclide in the first area are selectively excited, there occurs a second polarization transfer from the spins of the second nuclide to the spins of the first nuclide and those first MR signals are collected from those spins of the first nuclides in the first area experiencing the first and second polarization transfers; and after the collection of the first MR signals, a sixth RF pulse to the first nuclide is applied together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclides in the second area are selectively excited, there is a third polarization transfer from the spins of the second nuclide to the spins of the first nuclide and those second MR signals are collected from those spins of the first nuclides in the second area experiencing the first and second polarization transfers. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A magnetic resonance apparatus comprising:
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first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide; second applying means for applying, to a second nuclide magnetically coupled to the spins of the first nuclide, an RF pulse corresponding to a resonance frequency of the second nuclide; gradient magnetic field applying means for applying a gradient magnetic field; detecting means for detecting the MR signal from the spins of the first nuclide; and control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, whereby in the predetermined pulse sequence first and second RF pulses are applied to the first nuclide, a third RF pulse is applied, simultaneously with or after the application of the second RF pulse, to the second nuclide magnetically coupled to the spins of the first nuclide, and a refocusing RF pulse to the first nuclide and inversion RF pulse to the second nuclide are applied in an interval between the first RF pulse and the second RF pulse, whereby there occurs a first polarization transfer from the spins of the first nuclide to the spins of the second nuclide; after the first polarization transfer, a fourth RF pulse is applied to the second nuclide; the RF pulse is applied to the first nuclide in an interval between the third RF pulse and the fourth RF pulse; after the application of the fourth RF pulse, a fifth RF pulse is applied to the first nuclide together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclide in the first area are selectively excited, there occurs a second polarization transfer from the spins of the second nuclide to the spins of the first nuclide and those first MR signals are collected from the spins of the first nuclide in the first area experiencing first and second polarization transfers; and after the collection of the first MR signals, a sixth RF pulse is applied to the first nuclide together with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclide in a second area are selectively excited, there occurs a third polarization transfer from the spins of the second nuclide to the spins of the first nuclide and those second MR signals are collected from those spins of the first nuclides in the second area experiencing the first and third polarization transfers. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32)
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33. A magnetic resonance apparatus comprising:
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first applying means for applying, to a first nuclide of a subject, an RF pulse corresponding to a resonance frequency of the first nuclide; second applying means for applying, to a second nuclide, an RF pulse; gradient magnetic field applying means for applying a gradient magnetic field to the subject; detecting means for detecting the MR signal from the first nuclide; and control means for controlling the first applying means, second applying means, gradient magnetic field applying means and detecting means in accordance with a predetermined pulse sequence, whereby in the predetermined pulse sequence at least one of an RF pulse to the first nuclide and RF pulse to the second nuclide is applied to create a longitudinal spin order state of the first and second nuclides magnetically coupled to each other and, after this state, a first RF pulse to the first nuclide is applied simultaneously with at least one slice gradient magnetic field pulse, whereby the spins of the first nuclides in a first area are selectively excited and those first MR signals are collected from those spins of the first nuclides magnetically coupled to the spins of the second nuclide in the first area; and after the collection of the first MR signals, a second RF pulse to the first nuclide is applied simultaneously with at least one slice gradient magnetic field pulse, whereby those spins in the longitudinal spin order state of the first and second nuclides in the second area are excited and those second MR signals are collected from those spins of the first nuclides magnetically coupled to the spins of the second nuclides in the second area.
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Specification