Endothelium preserving microwave treatment for atherosclerosis

• US 6,047,216 A
• Filed: 08/05/1998
• Issued: 04/04/2000
• Est. Priority Date: 04/17/1996
• Status: Expired due to Term

• Current Assignee: National Aeronautics and Space Administration US Government As Represented By The Administrator of The, U.S. Government As Represented By The Administratoion, Washington, D.C. 20546
• Original Assignee: United States of America Asthe Administrator of The National Aeronautics and Space Administration
• Inventors: Fink, Patrick W., Beer, N. Reginald, Arndt, G. Dickey, Carl, James R., Raffoul, George W., Pacifico, Antonio, Henry, Phillip D.
• Primary Examiner(s): Gilbert, Samuel G.
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US09/129,832
• Time in Patent Office: 608 Days
• Field of Search: 607/100-102, 607/115-116, 607/122-123, 607/154-156, 606/33-42, 606/45-50, 604/22, 128/898
• US Class Current: 607/101
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00732 Frequency
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61N 1/06 for high-frequency therapy

Abstract

Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial laser and/or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20° C., within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed, directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and man be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.

Claims

1. A method for thermally heating an atherosclerotic lesion in an artery to treat atherosclerosis while preserving an endothelial layer of said artery, comprising:

providing a catheter with a microwave radiator at one end thereof;

selecting a frequency of operation for said microwave radiator within a frequency range of from about 2 Gigahertz to about 300 Gigahertz;

selecting a microwave power level of operation, time duration of radiation, and frequency of operation such that a heat rise due to energy deposition in said endothelial layer is limited by a blood flow rate and a specific heat of said blood to within a selected temperature rise less than an amount that will damage said endothelial layer.

2. The method of claim 1, further comprising:

selecting said frequency such that a profile of said heat rise due to energy deposition is maximum within in said atherosclerotic lesion as compared to tissues and fluid surrounding said atherosclerotic lesion.

3. The method of claim 1, further comprising:

selecting a time duration of radiation of less than two seconds for necrosing living tissue within said atherosclerotic lesion.

4. The method of claim 1, further comprising:

directing microwaves at a radial segment of said artery in which said atherosclerotic lesion is substantially positioned.

5. The method of claim 4, further comprising:

providing a radially directable wave guide for use in directing microwaves.

6. The method of claim 5, further comprising:

selecting said frequency of operation in the range of 25 GHz to 300 GHz.

7. The method of claim 5, further comprising:

providing a radically beveled open ended waveguide antenna.

8. The method of claim 1, further comprising:

generating frequency in the range of 15 GHz to 300 GHz with an oscillator chip positioned on a distal portion of said catheter.

9. The method of claim 8, further comprising

sequentially connecting two or more of said chips together with a microstrip to increase radiation power from said catheter without significantly increasing a diameter of said catheter.