Compositions and delivery systems for the topical treatment of psoriasis and other conditions of the skin

• US 6,048,886 A
• Filed: 09/30/1999
• Issued: 04/11/2000
• Est. Priority Date: 10/05/1998
• Status: Expired due to Fees

• Current Assignee: Stanley Neigut
• Original Assignee: Stanley Neigut
• Inventors: Neigut, Stanley
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US09/409,278
• Time in Patent Office: 194 Days
• Field of Search: 514/690
• US Class Current: 514/412
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/122 having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Abstract

The invention provides compositions and methods for the application of those compositions in order to treat biological surfaces, especially the skin. The compositions contain a ubiquinone, may include other antioxidant agents (including melatonin), and may include an abrasive. The means of application may be by rubbing the composition into the skin, by means of a transdermal patch, or by rubbing the composition into the skin followed by application of a transdermal patch. The compositions and methods are useful for treating a variety of skin conditions, including psoriasis and hyper-pigmentation, and may also be used for cosmetic purposes and the prevention of skin damage.

Claims

1. A method for preventing or treating skin disorders, comprising:

applying a composition including a ubiquinone and an abrasive to skin, said abrasive being present in an amount ranging from 1-99 weight % and said ubiquinone being present in an amount ranging from 0.01 to 99 weight %.

2. The method of claim 1 wherein said applying is performed by rubbing said composition against said skin.

3. The method of claim 1 wherein said composition includes an antioxidant.

4. The method of claim 1 wherein said composition includes melatonin, said melatonin being present in an amount ranging from 0.1 to 99 weight %.

5. The method of claim 1 further comprising the step of applying a patch containing a ubiquinone to said skin.

11. The method of claim 1 wherein said skin disorder is selected from the group consisting of:

psoriasis, rosacea, photodamaged skin, atopic dermatitis and seborrheic dermatitis.

12. The method of claim 11 wherein said skin disorder is psoriasis.

13. The method of claim 11 wherein said skin disorder is rosacea.

14. The method of claim 11 wherein said skin disorder is photodamaged skin.

15. The method of claim 11 wherein said skin disorder is atopic dermatitis.

16. The method of claim 11 wherein said skin disorder is seborrheic dermatitis.

23. The method of claim 1 wherein said composition includes amino acids.

6. A method for preventing or treating skin disorders, comprising:

positioning a patch on skin, said patch including a ubiquinone which can be delivered therefrom to said skin.

7. The method of claim 6 further comprising the step of treating said skin with an abrasive prior to said positioning step.

8. The method of claim 7 wherein said abrasive is used in combination with a ubiquinone.

9. The method of claim 6 wherein said patch further includes an antioxidant.

10. The method of claim 6 wherein said patch further includes melatonin, said melatonin being present in an amount ranging from 0.1 to 99 weight %.

17. The method of claim 6 wherein said skin disorder is selected from the group consisting of:

psoriasis, rosacea, photodamaged skin, atopic dermatitis and seborrheic dermatitis.

18. The method of claim 17 wherein said skin disorder is psoriasis.

19. The method of claim 17 wherein said skin disorder is rosacea.

20. The method of claim 17 wherein said skin disorder is photodamaged skin.

21. The method of claim 17 wherein said skin disorder is atopic dermatitis.

22. The method of claim 17 wherein said skin disorder is seborrheic dermatitis.

24. The method of claim 6 wherein said composition includes amino acids.