Cardiac rhythm management device with detection and therapy for sudden syncopal events

• US 6,049,735 A
• Filed: 03/01/1999
• Issued: 04/11/2000
• Est. Priority Date: 03/01/1999
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Stahl, Wyatt, Voegele, John, Hartley, Jesse W.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/259,349
• Time in Patent Office: 407 Days
• Field of Search: 607/9, 607/23
• US Class Current: 607/9
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A method and apparatus for cardiac stimulation for addressing vasovagal syncope incorporates a detection algorithm in which a precipitous rate drop from a pre-existing average intrinsic heart rate value to a lower rate limit is sensed and if the patient is awake and the intrinsic rate remains below the lower rate limit for a predetermined number of beats, the patient'"'"'s heart is paced at a rate that is a programmed differential above the prior average intrinsic rate for a second programmed time interval, at the conclusion of which the pacing rate is gradually decreased to the average heart rate existing prior to the sudden rate drop or to the lower rate limit.

Claims

1. In an implantable cardiac rhythm management device having means for detecting cardiac depolarization signals and for producing electrical signals related thereto, means for computing an average heart rate based upon the interval between the electrical signals, and pulse generator means for producing cardiac stimulating pulses, a means for treating vasovagal syncope comprising:

(a) means for sensing a drop in intrinsic heart rate from the average heart rate to a predetermined lower rate threshold value for a prescribed number of beats; and

(b) therapy delivery means responsive to the rate drop sensing means controlling the pulse generator means for generating cardiac stimulating pulses at a predetermined differential rate in excess of an average heart rate value existing immediately prior to a sensed drop in heart rate by the rate drop sensing means.

2. The implantable cardiac rhythm management device of claim 1 wherein the pulse generator means is operative to deliver a predetermined number of cardiac stimulating pulses at the lower rate threshold value prior to activation of the therapy delivery means.

3. The implantable cardiac rhythm management device of claim 2 wherein the therapy delivery means remains operative for a predetermined time interval following activation thereof.

4. The implantable cardiac rhythm management device of claim 2 wherein the device is a rate responsive pacemaker and the lower rate threshold value is a sensor determined rate.

5. The implantable cardiac rhythm management device of claim 1 wherein the means for computing an average heart rate performs a weighted auto-regressive average calculation based on a predetermined number, N, of immediately preceding intrinsic beats.

6. The implantable cardiac rhythm management device of claim 5 wherein the weighted auto-regressive average calculation forms the sum of 1/N times a current rate and (N-1)/N times a preceding average rate on a beat-by-beat basis.

7. In an implantable cardiac rhythm management device having means for detecting cardiac depolarization signals and producing electrical signals related thereto, means for determining minute ventilation of a patient in whom the implantable cardiac rhythm management device is implanted, means for computing an average heart rate based upon the interval between the electrical signals, and pulse generating means for producing cardiac stimulating pulses, a means for treating vasovagal syncope comprising:

(a) means for sensing a drop in intrinsic heart rate from the average heart rate to a predetermined lower rate threshold value;

(b) means responsive to the means for determining minute ventilation for deriving a respiratory rate parameter; and

(c) therapy delivery means responsive to the rate drop sensing means and the respiratory rate parameter for controlling the pulse generator means for generating cardiac stimulating pulses at a predetermined differential rate in excess of an average heart rate value existing immediately prior to a sensed drop in heart rate by the rate drop sensing means only when the respiratory rate parameter is above a prescribed threshold.

8. The implantable cardiac rhythm management device of claim 7 wherein the pulse generator means is operative to delivery a predetermined number of cardiac stimulating pulses at the predetermined lower rate threshold prior to activation of the therapy delivery means.

9. The implantable cardiac rhythm management device of claim 8 wherein the therapy delivery means remains operative for a predetermined time interval following activation thereof.

10. The implantable cardiac rhythm management device of claim 7 wherein the means for computing an average heart rate performs a weighted auto-regressive average calculation based on a predetermined number, N, of immediately preceding intrinsic beats.

11. The implantable cardiac rhythm management device of claim 10 wherein the average calculation forms a sum of 1/N times a current rate and (N-1)/N times a preceding average rate on a beat-by-beat basis.

12. The implantable cardiac rhythm management device of claim 7 wherein the device is a rate responsive pacemaker and the predetermined lower rate threshold value is a sensor indicated rate.

13. In an implantable cardiac rhythm management device having means for detecting cardiac depolarization signals and producing electrical signals related and producing electrical signals related thereto, means for computing an average heart rate based upon an interval between electrical signals, means for sensing a parameter proportional to hemodynamic demand of the patient, and pulse generator means controlled by the parameter sensing means for providing cardiac stimulating pulses at a rate between a lower sensor rate limit and an upper sensor rate limit, as determined by said parameter, a means for treating vasovagal syncope, comprising:

(a) means for sensing a drop in heart rate from the average heart rate to said lower sensor rate limit; and

(b) therapy delivery means responsive to the rate drop sensing means for controlling the pulse generator means for generating cardiac stimulating pulses at a predetermined differential rate in excess of an average heart rate value existing immediately prior to a sensed drop in heart rate by the rate drop sensing means.

14. A method of cardiac pacing, comprising the steps of:

(a) detecting depolarizations of the heart;

(b) computing from the detected depolarizations a running average of heart beat rate;

(c) detecting a sudden drop in intrinsic heart beat rate to a predetermined lower rate threshold; and

(d) delivering cardiac pacing pulses at a rate that is a predetermined rate differential above the computed average heart beat rate over a predetermined time interval.