Apparatus and method for treating tissue with multiple electrodes

• US 6,050,992 A
• Filed: 05/19/1997
• Issued: 04/18/2000
• Est. Priority Date: 05/19/1997
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: RadioTherapeutics Corp (Boston Scientific Corporation)
• Inventors: Nichols, Colin J.
• Primary Examiner(s): COHEN, LEE S
• Application Number:
  US08/858,414
• Time in Patent Office: 1,065 Days
• Field of Search: 606/41, 606/49, 606/50, 606/129, 607/98, 607/99, 607/113, 607/116, 607/122, 607/128, 600/505, 600/375, 600/376
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1477 Needle-like probes

Abstract

A probe system for volumetric tissue heating and ablation comprises a cannula having a multiple electrode component reciprocatably mounted therein. Individual electrodes within the array have spring memory so that they assume a radially outward, arcuate configuration as they are advanced distally from the cannula. Preferably, the electrodes fully evert as they are advanced from the cannula. Prior to deployment, the electrodes are constrained within a lumen of the cannula. The electrodes are maintained with a uniform circumferential spacing by confining them within an annular envelope defined by a core member within the cannula lumen, by providing electrodes having asymmetric cross-sectional geometries, and/or by nesting the electrodes closely together. Optionally, a cutting current may be applied to the electrodes as they are advanced.

Claims

1. A probe system for penetrating a plurality of electrodes into tissue, said probe system comprising:

a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end,

a core disposed coaxially within the cannula lumen, said core having a cylindrical outer surface which together with an inner surface of the cannula lumen defines an annular envelope; and

a plurality of resilient electrodes disposed in the annular envelope wherein at least a portion of the electrodes are mechanically coupled to the core to reciprocate between a proximally retracted position wherein all electrodes are radially constrained within the lumen and a distally extended position wherein all electrodes deploy radially outwardly, said plurality including at least three electrodes,

whereby the envelope maintains substantially equal circumferential spacing between adjacent electrodes when retracted in the cannula lumen.

2. A probe system as in claim 1, wherein the core has a sharpened distal end to facilitate penetration into tissue.

3. A probe system as in claim 1, wherein the core is electrically coupled to the electrodes.

4. A probe system as in claim 1, wherein the core is electrically isolated from the electrodes.

5. A probe system as in claim 1, wherein at least one of the outer cylindrical surface of the core and the inner surface of the cannula lumen has channels formed therein for receiving and aligning the electrodes.

6. A probe system as in claim 1, wherein the annular envelope has a width in a radial direction which is less than or equal to a distance twice that of the thickness of an electrode.

7. A probe system as in claim 1, wherein at least some of the electrodes are shaped so that they assume an outwardly everted configuration as they are extended distally into tissue from the distal end of the cannula.

8. A probe system as in claim 1, further comprising a stylet reciprocatably received in the cannula lumen, wherein the stylet may be used for initially positioning the cannula in tissue and thereafter exchanged with the electrodes.

9. A probe system as in claim 1, wherein the cannula has a length in the range from 5 cm to 30 cm and an outer diameter in the range from 1 mm to 5 mm.

10. A probe system as in claim 1, wherein the electrodes deploy outwardly to a radius in the range from 0.5 cm to 3 cm when fully distally extended from the cannula.

11. A probe system as in claim 1, wherein the plurality includes at least five electrodes.

12. A probe system as in claim 1, wherein the plurality includes at least eight electrodes.

13. A probe system as in claim 1, wherein the plurality includes at least ten electrodes.

14. A probe system for penetrating a plurality of electrodes into tissue, said probe system comprising:

a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end; and

a plurality of resilient electrodes, at least a portion having asymmetric cross-sections with a major dimension aligned circumferentially and a minor dimension aligned radially, disposed in the cannula lumen to reciprocate between a proximally retracted position wherein all electrodes are radially constrained within the lumen and a distally extended position wherein all electrodes deploy radially outwardly, said plurality including at least three electrodes,

whereby the shape and alignment of the electrodes maintains substantially equal circumferential spacing between adjacent electrodes when retracted in the cannula lumen.

15. A probe system as in claim 14, wherein the major dimension is at least 50% larger than the minor dimension.

16. A probe system as in claim 15, wherein the electrodes have a rectangular cross-section.

17. A probe system as in claim 14, wherein the electrodes are nested together in a close packed configuration within an annular ring.

18. A probe system as in claim 14, wherein at least some of the electrodes are shaped so that they assume an outwardly everted configuration as they are extended distally into tissue from the distal end of the cannula.

19. A probe system as in claim 14, further comprising a stylet reciprocatably received in the cannula lumen, wherein the stylet may be used for initially positioning the cannula in tissue and thereafter exchanged with the electrodes.

20. A probe system as in claim 14, wherein the cannula has a length in the range from 5 cm to 30 cm and an outer diameter in the range from 1 mm to 5 mm.

21. A probe system as in claim 14, wherein the electrodes deploy outwardly to a radius in the range from 0.5 cm to 3 cm when fully distally extended from the cannula.

22. A probe system as in claim 14, wherein the plurality includes at least five electrodes.

23. A probe system as in claim 14, wherein the plurality includes at least eight electrodes.

24. A probe system as in claim 14, wherein the plurality includes at least ten electrodes.

25. A probe system comprising:

a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end,

a cylindrical core disposed coaxially within the cannula lumen to define an annular envelope; and

a plurality of resilient electrodes disposed in the annular envelope to reciprocate between a proximally retracted position wherein all electrodes are radially constrained within the envelope and a distally extended position wherein all electrodes deploy radially outwardly, at least a portion of said electrodes having asymmetric cross-sections with a major dimension aligned circumferentially within the annular envelope and a minor dimension aligned radially within the annular envelope.

26. A probe system as in claim 25, wherein the core is mechanically coupled to and reciprocates with the electrodes.

27. A probe system as in claim 26, wherein the core has a sharpened distal end to facilitate penetration into tissue.

28. A probe system as in claim 25, wherein the core is electrically coupled to the electrodes.

29. A probe system as in claim 25, wherein the core is electrically isolated from the electrodes.

30. A probe system as in claim 25, wherein the core is mechanically coupled to the cannula so that the electrodes translate past the surface of the core as the electrodes are advanced distally from the cannula.

31. A probe system as in claim 25, wherein at least one of the outer cylindrical surface of the core and the inner surface of the cannula lumen has channels formed therein for receiving and aligning the electrodes.

32. A probe system as in claim 25, wherein the annular envelope has a width in a radial direction which is less than or equal to a distance twice that of the thickness of an electrode.

33. A probe system as in claim 25, wherein the major dimension of the electrode cross-section is at least 50% larger than the minor dimension.

34. A probe system as in claim 33, wherein the electrodes have a rectangular or trapezoidal cross-section.

35. A probe system as in claim 25, wherein at least some of the electrodes are shaped so that they assume an outwardly everted configuration as they are extended distally into tissue from the distal end of the cannula.

36. A probe system as in claim 25, further comprising a stylet reciprocatably received in the cannula lumen, wherein the stylet may be used for initially positioning the cannula in tissue and thereafter exchanged with the electrodes.

37. A probe system as in claim 25, wherein the cannula has a length in the range from 5 cm to 30 cm and an outer diameter in the range from 1 mm to 5 mm.

38. A probe system as in claim 25, wherein the electrodes deploy outwardly to a radius in the range from 0.5 cm to 3 cm when fully distally extended from the cannula.

39. A probe system as in claim 25, wherein the plurality includes at least three electrodes.

40. A probe system as in claim 25, wherein the plurality includes at least five electrodes.

41. A probe system as in claim 25, wherein the plurality includes at least eight electrodes.

42. A probe system as in claim 25, wherein the plurality includes at least ten electrodes.

43. A probe system comprising:

a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end; and

at least four electrodes reciprocatably disposed within the lumen of the cannula, wherein the electrodes are nested within an annulus within the cannula lumen when retracted therein, each said electrode having an asymmetric cross-section.

44. A probe system as in claim 43, including at least eight electrodes.

45. A probe system as in claim 43, wherein the annulus is constrained to have a width in a radial direction which is less than or equal to a distance twice that of the thickness of an electrode.

46. A probe system as in claim 43, wherein the asymmetric cross-sections are rectangular or trapezoidal.

47. A probe system as in claim 43, wherein at least some of the electrodes are shaped so that they assume an outwardly everted configuration as they are extended distally into tissue from the distal end of the cannula.

48. A probe system as in claim 43, wherein the cannula has a length in the range from 5 cm to 30 cm and an outer diameter in the range from 1 mm to 5 mm.

49. A probe system as in claim 43, wherein the electrodes deploy outwardly to a radius in the range from 0.5 cm to 3 cm when fully distally extended from the cannula.

51. A method as in claim 49, wherein the electrode distal tips are disposed in an annular region defined between an outer cylindrical surface of a core member disposed in the cannula and an inner cylindrical surface of a lumen of the cannula, wherein the distance between said outer cylindrical surface and said inner cylindrical surface is no more than twice that of the thickness of an electrode.

50. A method for delivering current to a target region within solid tissue comprising:

constraining a plurality of at least three electrodes within a cannula, wherein at least a portion of the electrodes have an asymmetrical cross-section and a distal tip arranged in a pattern whereby the distal tips are substantially equally spaced-apart within an annular region near a distal end of the cannula,

advancing the electrodes distally from the cannula into tissue at the target region, wherein the electrodes deploy radially outwardly in a symmetric pattern into the tissue; and

applying electrical current to the tissue through the electrodes.

52. A method in claim 50, wherein a cannula lumen reciprocatably receives a core, said core having a cylindrical outer surface which together with the inner surface of the cannula lumen defines the annular region.

53. A method as in claim 52, wherein the core advances into the tissue together with the electrodes.

54. A method as in claim 52, wherein the electrodes advance past the core which remains immobile relative to the cannula.

55. A method as in claim 50, wherein the asymmetric cross-sections have a major dimension aligned circumferentially to maintain axial alignment of the electrodes and minor dimension aligned radially, where the electrodes are shaped to bend about an axis parallel to the minor dimension as the electrodes are advanced distally from the cannula.

56. A method as in claim 50, wherein the tips of the electrodes are nested within an annulus near the distal end of the cannula lumen prior to advancement.

57. A method as in claim 50, wherein the current is radio frequency current.

58. A method as in claim 50, wherein the electrodes are attached to one pole of a current source and a dispersive electrode is attached to another pole of the current source.

59. A method as in claim 50, wherein some of the electrodes are attached to one pole of a current source and others of the electrodes are attached to another pole of the current source to deliver current in a bipolar manner.

60. A method for deploying electrodes in tissue, said method comprising:

providing a plurality of at least three asymmetric electrodes constrained within a cannula; and

advancing each of the electrodes distally from the cannula into tissue, wherein spacing between adjacent electrodes is maintained within ±

20% of the average distance between electrodes as the electrodes are advanced.

61. A method as in claim 60, wherein the spacing is maintained to within ±

10% of the average distance.

62. A method as in claim 60, wherein the spacing is maintained to within ±

5% of the average distance.

63. A method as in claim 60, wherein the spacing is further maintained by a central core within the cannula.

64. A method as in claim 60, wherein the spacing is further maintained by providing the electrodes in a nested configuration.

65. A method as in claim 60, further comprising applying a cutting RF current to the electrodes as they are advanced.

66. A method as in claim 65, further comprising applying an ablating RF current to the electrodes after they are advanced.