Methods for on line finishing of cellular blood products like platelets harvested for therapeutic purposes
First Claim
1. An on line blood processing method for obtaining for storage a platelet suspension having a reduced residual leukocyte population comprising the steps of(1) establishing on line communication between a storage container and a donor of blood containing leukocytes and platelets,(2) creating, without interrupting the on line communication between the storage container and the donor of blood, a centrifugal field between the donor of blood and the storage container that separates from the blood a first platelet suspension having an initial population of leukocytes greater than the reduced residual population of leukocytes,(3) pumping, without interrupting the on line communication between the storage container and the donor of blood, the first platelet suspension outside the centrifugal field through a finishing device under pressure from the centrifugal field, the finishing device operating to reduce the initial leukocyte population in the first platelet suspension, thereby creating a second platelet suspension having a reduced residual leukocyte population less than the initial population of leukocytes, and(4) conveying, without interrupting the on line communication between the storage container and the donor of blood, the second platelet suspension from the finishing device directly into the storage container without exposure to the separation forces of the centrifugal field.
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Accused Products
Abstract
Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.
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Citations
4 Claims
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1. An on line blood processing method for obtaining for storage a platelet suspension having a reduced residual leukocyte population comprising the steps of
(1) establishing on line communication between a storage container and a donor of blood containing leukocytes and platelets, (2) creating, without interrupting the on line communication between the storage container and the donor of blood, a centrifugal field between the donor of blood and the storage container that separates from the blood a first platelet suspension having an initial population of leukocytes greater than the reduced residual population of leukocytes, (3) pumping, without interrupting the on line communication between the storage container and the donor of blood, the first platelet suspension outside the centrifugal field through a finishing device under pressure from the centrifugal field, the finishing device operating to reduce the initial leukocyte population in the first platelet suspension, thereby creating a second platelet suspension having a reduced residual leukocyte population less than the initial population of leukocytes, and (4) conveying, without interrupting the on line communication between the storage container and the donor of blood, the second platelet suspension from the finishing device directly into the storage container without exposure to the separation forces of the centrifugal field.
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2. An on line blood processing method for obtaining for storage a platelet suspension having a desired physiologic characteristic comprising the steps of
(1) establishing on line communication between a storage container and a donor of blood containing platelets, (2) creating, without interrupting the on line communication between the storage container and the donor of blood, a centrifugal field between the donor of blood and the storage container that separates from the blood a first platelet suspension having a first physiologic characteristic different than the desired physiologic characteristic, (3) pumping, without interrupting the on line communication between the storage container and the donor of blood, the first platelet suspension outside the centrifugal field through a finishing device under pressure from the centrifugal field, the finishing device operating to change the first physiologic characteristic to the desired physiological characteristic, thereby creating a second platelet suspension having the desired physiological characteristic, and (4) conveying, without interrupting the on line communication between the storage container and the donor of blood, the second platelet suspension from the finishing device directly into the container without exposure to the separation forces of the centrifugal field.
Specification