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Composition for sustained release of human growth hormone

  • US 6,051,259 A
  • Filed: 02/19/1999
  • Issued: 04/18/2000
  • Est. Priority Date: 12/02/1992
  • Status: Expired due to Fees
First Claim
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1. A composition for the sustained release of human growth hormone from a polymer matrix comprising:

  • a) poly(lactide-co-glycolide); and

    b) particles of zinc-complexed human growth hormone, with a zinc cation component-to-human growth hormone molar ratio between about 4;

    1 and about 100;

    1, wherein said particles are dispersed within the poly(lactide-co-glycolide) and wherein the proportion of human growth hormone in the sustained release composition is between 10 and 30 weight percent.

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