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Methods of screening nucleic acids using mass spectrometry

  • US 6,051,378 A
  • Filed: 03/04/1997
  • Issued: 04/18/2000
  • Est. Priority Date: 03/04/1996
  • Status: Expired due to Term
First Claim
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1. A method of detecting mutations in a target nucleic acid comprising:

  • obtaining from said target nucleic acid, a set of nonrandom length fragments (NLFs) in single stranded form, wherein said set comprises NLFs derived from a single-stranded or double-stranded target nucleic acid, wherein said set of single stranded NLFs does not comprise the entirety of fragments generated from non-randomly fragmenting a double-stranded target nucleic acid, and determining masses of the members of said set using mass spectrometry.

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