Vascular embolizing compositions comprising ethyl lactate and methods for their use

• US 6,051,607 A
• Filed: 07/02/1998
• Issued: 04/18/2000
• Est. Priority Date: 07/02/1998
• Status: Expired due to Term

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Micro Therapeutics, Inc. (Medtronic Plc)
• Inventors: Greff, Richard J.
• Primary Examiner(s): Pak, John
• Assistant Examiner(s): CHOI, FRANK I
• Application Number:
  US09/109,041
• Time in Patent Office: 656 Days
• Field of Search: 424/9.4, 424/9.41, 424/9.411, 424/9.42, 424/9.43, 424/78.08, 514/57, 514/506, 514/529, 514/546, 514/834, 514/930, 604/264, 604/52, 604/53, 604/56, 604/49, 604/96, 604/523, 604/508, 604/509, 604/507, 206/569, 206/570, 206/571
• US Class Current: 514/546
• CPC Class Codes: A61K 49/0404 containing barium sulfate
• CPC Class Codes: A61K 49/0419 Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/04 containing macromolecular materials
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08L 1/12 Cellulose acetate

Abstract

Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. In one embodiment, the compositions of this invention comprise a biocompatible polymer, ethyl lactate solvent and a biocompatible contrast agent.

Claims

1. A composition suitable for use in therapeutically embolizing blood vessels which composition comprises:

(a) a solution of a biocompatible chemically inert polymer and ethyl lactate; and

(b) a contrast agent selected from the group consisting of a water insoluble contrast agent and a water soluble contrast agent,

wherein the polymer has a solubility of at least 0.04 g/mL at 20°

C. in ethyl lactate.

2. The composition according to claim 1 wherein said contrast agent is a water insoluble contrast agent selected from the group consisting of tantalum, tantalum oxide, tungsten, and barium sulfate.

3. The composition according to claim 2 wherein said contrast agent has an average particle size of from 1 to 10 microns.

4. The composition according to claim 2 wherein said contrast agent is tantalum.

5. The composition according to claim 1 wherein said biocompatible polymer is a cellulose acetate.

6. The composition according to claim 5 wherein said biocompatible polymer is cellulose diacetate.

7. A method for therapeutically embolizing a blood vessel by delivering via a catheter into said blood vessel a composition comprising:

(a) a solution of a biocompatible, chemically inert polymer and ethyl lactate; and

(b) a contrast agent selected form the group consisting of a water insoluble contrast agent and a water soluble contrast agent

under conditions wherein a precipitate is formed which embolizes the blood vessel, wherein the polymer has a solubility of at least 0.04 g/mL at 20°

C. in ethyl lactate.

8. The method according to claim 7 wherein said contrast agent is a water insoluble contrast agent selected from the group consisting of tantalum, tantalum oxide, tungsten, and banium sulfate.

9. The method according to claim 8 wherein said contrast agent has an average particle size of from 1 to 10 microns.

10. The method according to claim 7 wherein said biocompatible polymer is a cellulose acetate.

11. The method according to claim 10 wherein said biocompatible polymer is cellulose diacetate.

12. A lit of parts suitable for use in therapeutically embolizing blood vessels comprising:

Part (a) a polymer composition comprising a solution of a biocompatible, chemically inert polymer and ethyl lactate, and a contrast agent selected from the group consisting of water insoluble contrast agent and a water soluble contrast agent wherein the polymer has a solubility of at least 0.04 g/mL at 20°

C. in ethyl lactate; and

Part (b) a catheter.

13. The kit of parts according to claim 12 wherein said contrast agent is a water insoluble contrast agent selected from the group consisting of tantalum, tantalum oxide, tungsten, and barium sulfate.

14. The kit of parts according to claim 13 wherein said contrast agent is tantalum.

15. The kit of parts according to claim 12 wherein said biocompatible polymer is a cellulose acetate.

16. The kit of parts according to claim 15 wherein said biocompatible polymer is cellulose diacetate.

17. The kit of parts according to claim 12 which further comprises a microballoon catheter to attenuate or arrest blood flow.