Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobias

• US 6,051,611 A
• Filed: 12/22/1998
• Issued: 04/18/2000
• Est. Priority Date: 11/08/1991
• Status: Expired due to Fees

• Current Assignee: Alcon Research Limited (Nestle SA)
• Original Assignee: Alcon Laboratories Incorporated (Alcon Incorporated)
• Inventors: Kyba, Evan P., Park, Joonsup
• Primary Examiner(s): O SULLIVAN, PETER G
• Application Number:
  US09/117,839
• Time in Patent Office: 483 Days
• Field of Search: 424/78.04, 514/642, 514/912, 564/291, 564/292, 528/397
• US Class Current: 514/642
• CPC Class Codes: A61K 31/785 Polymers containing nitrogen
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds

Abstract

The invention relates to polymeric quaternary ammonium compounds which are useful as disinfectants and/or preservatives in ophthalmic compostions.

Claims

1. An ophthalmic composition comprising a polymeric quaternary ammonium compound of the structure:

space="preserve" listing-type="equation">W--CH.sub.2 CH═

CHCH.sub.2 --[N.sup.+ (CH.sub.3).sub.2 CH.sub.2 CH═

CHCH.sub.2 ].sub.n --W

space="preserve" listing-type="equation">nX.sup.-

wherein;

W=N(CH₃)₂ ;

X is a pharmaceutically acceptable anion; and

n is an integer from 16 to 32

and wherein the compound is present at a concentration between about 0.00001 and about 1.0 percent by weight.

2. The ophthalmic composition of claim 1, wherein the polymeric quaternary ammonium compound is present at a concentration between about 0.00005 and about 0.05 percent by weight.

3. The ophthalmic composition of claim 2, wherein the polymeric quaternary ammonium compound is present at a concentration between about 0.0001 and about 0.01 percent by weight.

4. A method of disinfecting a contact lens, comprising contacting a contact lens to a composition comprising an ophthalmically acceptable vehicle and a disinfecting amount of a substantially pure form of a polymeric quaternary ammonium compound of structure:

space="preserve" listing-type="equation">W--CH.sub.2 CH═

CHCH.sub.2 --[N.sup.+ (CH.sub.3).sub.2 CH.sub.2 CH═

CHCH.sub.2 ].sub.n --W

space="preserve" listing-type="equation">nX.sup.-

wherein;

W=N(CH₃)₂ ;

X is a pharmaceutically acceptable anion; and

n is an integer from 16 to 32.

5. The method of claim 4, wherein n is an integer from 20 to 24.

6. The method of claim 4, wherein X is a halide.

7. The method of claim 6, wherein X is chloride.

8. The method of claim 4, wherein the polymeric quaternary ammonium compound is present at a concentration between about 0.00001 and about 1.0 percent by weight.

9. The method of claim 8, wherein the polymeric quaternary ammonium compound is present at a concentration between about 0.0005 and about 0.5 percent by weight.

10. The method of claim 9, wherein the polymeric quaternary ammonium compound is present at a concentration between about 0.001 and about 0.05 percent by weight.