Receptor for the glucagon-like-peptide (GLP-1)
First Claim
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1. An isolated glucagon-like peptide-1 (GLP-1) receptor polypeptide comprising the amino acid sequence of a naturally-occurring mammalian GLP-1 receptor protein or of a fragment thereof, wherein the receptor protein or fragment is encoded by a cDNA molecule that is isolated from a mammalian library and comprises the nucleotide sequence shown in SEQ ID NO:
- 1 or SEQ ID NO;
3, and wherein said receptor polypeptide binds GLP-1 with a KD of less than 100 nM.
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Abstract
The present invention relates to a recombinant glucagonlike peptide-1 (GLP-1) receptor having the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:3, wherein the receptor polypeptide binds GLP-1 with a Kd of less than 100 nM.
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Citations
2 Claims
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1. An isolated glucagon-like peptide-1 (GLP-1) receptor polypeptide comprising the amino acid sequence of a naturally-occurring mammalian GLP-1 receptor protein or of a fragment thereof, wherein the receptor protein or fragment is encoded by a cDNA molecule that is isolated from a mammalian library and comprises the nucleotide sequence shown in SEQ ID NO:
- 1 or SEQ ID NO;
3, and wherein said receptor polypeptide binds GLP-1 with a KD of less than 100 nM. - View Dependent Claims (2)
- 1 or SEQ ID NO;
Specification
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Current AssigneeNovo Nordisk A/S
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Original AssigneeNovo Nordisk A/S
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InventorsThorens, Bernard
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Primary Examiner(s)Fitzgerald, David L.
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Application NumberUS08/935,317Time in Patent Office939 DaysField of Search530/350, 435/69.1US Class Current530/350CPC Class CodesC07K 14/72 for hormones for neuromedia...G01N 2333/605 GlucagonsG01N 2333/72 for hormones
