×

Substituted aryl or heteroarylamides having retinoid-like biological activity

  • US 6,051,713 A
  • Filed: 12/17/1998
  • Issued: 04/18/2000
  • Est. Priority Date: 11/22/1995
  • Status: Expired due to Fees
First Claim
Patent Images

1. A compound of the formula ##STR10## wherein R1 is independently H or alkyl of 1 to 6 carbons;

  • m is an integer having the value of 0-5;

    p is an integer having the value of 0-2;

    r is an integer having the value 0-2;

    the pyridyl group bearing the A-B group is optionally substituted with one or two R1 groups;

    W is a substituent selected independently from the group consisting of F, Br, Cl, I, C1-6 alkyl, fluoro substituted C1-6 alkyl, NO2, N3, OH, OCH2 OCH3, OC1-10 alkyl, tetrazol, CN, SO2 C1-6 -alkyl, SO2 C1-6 -fluoro substituted alkyl, SO--C1-6 alkyl, CO--C1-6 alkyl, COOR8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl;

    A is (CH2)q where q is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds, andB is COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9 R10, --CH2 OH, CH2 OR11, CH2 OCOR11, CHO, CH(OR12)2, CHOR13 O, --COR7, CR7 (OR12)2, CR7 OR13 O, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R8 is an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11, is lower alkyl, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×