Optical coherence tomography with new interferometer

• US 6,053,613 A
• Filed: 05/15/1998
• Issued: 04/25/2000
• Est. Priority Date: 05/15/1998
• Status: Expired due to Term

• Current Assignee: Carl Zeiss Vision Incorporated (Carl-Zeiss-Stiftung)
• Original Assignee: Carl Zeiss Inc (Carl-Zeiss-Stiftung)
• Inventors: Huang, David, Petersen, Christopher L., Wei, Jay
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US09/079,908
• Time in Patent Office: 711 Days
• Field of Search: 382/103, 356/345, 356/357, 356/358, 356/360, 351/205, 351/206, 351/212, 606/4, 606/10
• US Class Current: 351/205
• CPC Class Codes: A61B 3/1005 for measuring distances inside the eye, e.g. thickness of the cornea A61B3/11 takes precedence
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: G01B 2290/15 Cat eye, i.e. reflection always parallel to incoming beam
• CPC Class Codes: G01B 2290/35 Mechanical variable delay line
• CPC Class Codes: G01B 9/02002 using two or more frequencies
• CPC Class Codes: G01B 9/02028 Two or more reference or object arms in one interferometer
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence

Abstract

Embodiments of the present invention are method and apparatus for simply and economically providing efficient scanning in an optical coherence tomography ("OCT") apparatus. In particular, an embodiment of the present invention is an OCT apparatus which examines an object, which OCT apparatus comprises: (a) a source of short coherence radiation; (b) a coupler which (i) couples a first portion of the radiation to a reference arm; (ii) couples a second portion of the radiation to a sample arm; (iii) combines radiation transmitted thereto from the reference path and the sample path; and (iv) couples the combined radiation to an analyzer; wherein (c) the reference arm transmits the first portion of the radiation to a measurement range variation apparatus and transmits radiation output from the measurement range variation apparatus back to the coupler; (d) the sample path transmits the second portion of the radiation to the object and transmits radiation scattered by the object back to the coupler; and (e) the measurement range variation apparatus comprises: (i) a transmitter which transmits a portion of the radiation incident thereupon; (ii) a reflector which reflects radiation transmitted by the transmitter; and (iii) a scanner coupled to scan the reflector.

Claims

1. An optical coherence tomography apparatus ("OCT") which examines an object, which OCT apparatus comprises:

a source of short coherence radiation;

a coupler which;

(a) couples a first portion of the radiation to a reference arm;

(b) couples a second portion of the radiation to a sample arm;

(c) combines radiation transmitted thereto from the reference arm and the sample arm; and

(d) couples the combined radiation to an analyzer;

wherein;

the reference arm transmits the first portion of the radiation to a measurement range variation apparatus and transmits radiation output from the measurement range variation apparatus back to the coupler;

the sample arm transmits the second portion of the radiation to the object and transmits radiation scattered by the object back to the coupler; and

the measurement range variation apparatus comprises;

a transmitter which transmits a portion of the radiation incident thereupon;

a reflector which reflects radiation transmitted by the transmitter, which transmitter reflects a portion of the reflected radiation; and

a scanner coupled to scan the reflector.

2. The OCT apparatus of claim 1 wherein the analyzer comprises:

a photodetector which detects radiation coupled from the coupler;

a mixer responsive to output from the photodetector and an oscillator; and

a filter coupled to the output from the mixer.

3. The OCT apparatus of claim 2 wherein the oscillator is a tunable oscillator.

4. The OCT apparatus of claim 2 wherein the filter has a passband frequency centered substantially at a frequency output from the mixer determined from a frequency of the oscillator and a frequency proportional to a Doppler shift frequency produced by scanning the reflector in the output from the photodetector.

5. The OCT apparatus of claim 4 wherein the frequency of the oscillator comprises a first frequency plus a frequency proportional to the Doppler shift frequency.

6. The OCT apparatus of claim 4 wherein passband frequency is centered at the difference between the frequency of the oscillator and the Doppler shift frequency.

7. The OCT apparatus of claim 1 wherein the reflector is a retroreflector.

8. The OCT apparatus of claim 1 which measures a distance between a first and a second scattering portion in the object wherein:

the measurement range variation apparatus further comprises a translator coupled to translate the transmitter; and

the analyzer comprises;

a photodetector which detects radiation coupled from the coupler;

a first filter coupled to output from the photodetector and having a passband centered substantially at a frequency proportional to a Doppler shift frequency produced by scanning the reflector; and

a second filter coupled to the output from the photodetector having a passband centered substantially at a multiple of the frequency.

9. The OCT apparatus of claim 8 wherein the analyzer further comprises a display which displays a signal generated as a result of radiation scattered from the first scattering portion and a signal generated as a result of radiation scattered from the second scattering portion.

10. The OCT apparatus of claim 9 wherein the measurement range variation apparatus further comprises an encoder which measures the position of the transmitter.

11. The OCT apparatus of claim 10 wherein the analyzer further comprises a computer which sends a signal to the translator to cause the two signals to coincide and receives a signal from the encoder to provide thereby a measurement of the distance.

12. The OCT apparatus of claim 8 wherein:

the measurement range variation apparatus further comprises an encoder which measures the position of the transmitter; and

the analyzer further comprises a computer which sends a signal to the translator to cause a first signal output from the first filter and a second signal output from the second filter to overlap, and receives a signal from the encoder to determine the measurement of the distance.

13. The OCT apparatus of claim 1 which measures a distance between a first and a second scattering portion in the object wherein:

the measurement range variation apparatus further comprises a translator coupled to translate the third reflector; and

the analyzer comprises;

a photodetector which detects radiation coupled from the coupler; and

a filter coupled to output from the photodetector and having a passband centered substantially at a frequency proportional to a Doppler shift frequency produced by scanning the first reflector.

14. The OCT apparatus of claim 13 wherein the analyzer further comprises a display which displays a signal generated as a result of radiation scattered from the first scattering portion and a signal generated as a result of radiation scattered from the second scattering portion.

15. The OCT apparatus of claim 14 wherein the measurement range variation apparatus further comprises an encoder which measures the position of the third reflector.

16. The OCT apparatus of claim 15 wherein the analyzer further comprises a computer which sends a signal to the translator to cause the two signals to coincide and receives a signal from the encoder to provide thereby a measurement of the distance.

17. The OCT apparatus of claim 13 wherein:

the measurement range variation apparatus further comprises an encoder which measures the position of the third reflector; and

the analyzer further comprises a computer which sends a signal to the translator to cause a first signal generated as a result of radiation scattered from the first scattering portion and a second signal generated as a result of radiation scattered from the second scattering portion to overlap, and

receives a signal from the encoder to determine the measurement of the distance.

18. An optical coherence tomography apparatus ("OCT") which examines an object, which OCT apparatus comprises:

a source of short coherence radiation;

a coupler which;

(a) couples a first portion of the radiation to a reference arm;

(b) couples a second portion of the radiation to a sample arm;

(c) combines radiation transmitted thereto from the reference arm and the sample arm; and

(d) couples the combined radiation to an analyzer;

wherein;

the reference arm transmits the first portion of the radiation to a measurement range variation apparatus and transmits radiation output from the measurement range variation apparatus back to the coupler;

the sample arm transmits the second portion of the radiation to the object and transmits radiation scattered by the object back to the coupler; and

the measurement range variation apparatus comprises;

a beamsplitter which transmits a portion of the radiation incident thereupon in a direction from the reference arm to a first reflector;

second and third reflectors disposed to reflect radiation incident thereupon along a second direction; and

a scanner coupled to scan the first reflector.

19. The OCT apparatus of claim 18 wherein the first reflector is a retroreflector.

20. A measurement range variation apparatus for use in a reference arm of an optical coherence tomography apparatus comprises:

a transmitter which transmits a portion of radiation incident thereupon;

a translator coupled to translate the transmitter;

a reflector which reflects radiation transmitted by the transmitter, which transmitter reflects a portion of the reflected radiation;

a scanner coupled to scan the reflector; and

an encoder which measures the position of the transmitter.

21. A measurement range variation apparatus for use in a reference arm of an optical coherence tomography apparatus comprises:

a beamsplitter which transmits a portion of radiation incident thereupon in a direction to a first reflector;

second and third reflectors disposed to reflect radiation incident thereupon along a second direction;

a scanner coupled to scan the first reflector;

a translator coupled to translate the third reflector; and

an encoder which measures the position of the third reflector.

22. A method for examining an object which comprises the steps of:

generating short coherence radiation;

coupling a first portion of the radiation into a reference arm and a second portion of the radiation into a sample arm;

in the reference arm, transmitting the first portion of the radiation to a measurement range variation apparatus which comprises a transmitter which transmits a portion of the radiation incident thereupon;

a reflector which reflects radiation transmitted by the transmitter, which transmitter reflects a portion of the reflected radiation; and

a scanner coupled to scan the reflector;

in the sample arm, transmitting the second portion of the radiation to the object;

combining radiation scattered by the object with radiation obtained from the measurement range variation apparatus; and

analyzing the combined radiation.

23. The method of claim 22 which measures a distance between a first and a second scattering portion in the object wherein:

the measurement range variation apparatus further comprises a translator coupled to translate the transmitter; and

the step of analyzing comprises;

generating a signal by detecting the combined radiation;

filtering the signal using a first filter having a passband centered substantially at a frequency proportional to a Doppler shift frequency produced by scanning the reflector; and

filtering the signal using a second filter having a passband centered substantially at a multiple of the frequency.

24. The method of claim 23 wherein:

the measurement range variation apparatus further comprises an encoder which measures the position of the transmitter; and

the step of analyzing further comprises;

sending a signal to the translator to cause a first signal output from the first filter and a second signal output from the second filter to overlap, and

receiving a signal from the encoder to determine the measurement of the distance.

25. A method for examining an object which comprises the steps of:

generating short coherence radiation;

coupling a first portion of the radiation into a reference arm and a second portion of the radiation into a sample arm;

in the reference arm, transmitting the first portion of the radiation to a measurement range variation apparatus which comprises a beamsplitter which transmits a portion of the radiation incident thereupon in a direction from the reference arm to a first reflector;

second and third reflectors disposed to reflect radiation incident thereupon along a second direction; and

a scanner coupled to scan the first reflector;

in the sample arm, transmitting the second portion of the radiation to the object;

combining radiation scattered by the object with radiation obtained from the measurement range variation apparatus; and

analyzing the combined radiation.

26. The method of claim 25 which measures a distance between a first and a second scattering portion in the object wherein:

the measurement range variation apparatus further comprises a translator coupled to translate the third reflector; and

the step of analyzing comprises;

generating a signal by detecting the combined radiation; and

filtering the signal using a filter having a passband centered substantially at a frequency proportional to a Doppler shift frequency produced by scanning the first reflector.

27. The method of claim 26 wherein:

the measurement range variation apparatus further comprises an encoder which measures the position of the third reflector; and

the step of analyzing further comprises;

sending a signal to the translator to cause a first signal generated as a result of radiation scattered from the first scattering portion and a second signal generated as a result of radiation scattered from the second scattering portion to overlap; and

receiving a signal from the encoder to determine the measurement of the distance.